Pseudotumor cerebri causes: Difference between revisions

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Latest revision as of 14:26, 29 November 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Causes

Common causes

Pseudotumor cerebri may be caused by:

Intracranial venous outflow obstruction (venous sinus thrombosis, head trauma, polycythemia, thrombocytosis)
Endocrine dysfunction (obesity, cessation of corticosteroid therapy, Addison disease, hypoparathyroidism)
Vitamin/drug (growth hormone, hypervitaminosis A, tetracycline, minocycline, nalidixic acid)
Other (chronic hypercapnia, severe right heart failure, chronic meningitis, hypertensive encephalopathy, severe iron deficiency anemia)
Idiopathic^[1]

References

↑ Clinical Neurology 9E Aminoff

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[1] Clinical Neurology 9E Aminoff

[1]

@@ Line 5: / Line 5: @@
 ==Overview==
 ==Causes==
-* Increased production of CSF and reduced resorption: Normal CSF flow involves production at the [[Choroid plexus|choroid plexuses]] and absorption at the cranial and [[spinal nerve]] root arachnoid villi and granulations.  Impaired CSF absorption at the [[superior sagittal sinus]] or along the spinal nerve roots could therefore explain IIH and has been documented in 75-100% of IIH patients. Permeability along the blood-CSF barrier varies, producing an increasing [[oncotic pressure]] gradient between the CSF and venous system in a [[rostral]] to [[caudal]] progression.  It is speculated that variations in this oncotic pressure contribute to or impede CSF absorption.
-* obesity.(89 uptodate): Some evidences suggest that onesity can increase intra abdominal and intra cranial pressure and have a role in pathogenesis of IHH. (106 uptodate) In a study on 7 obese women with IHH it was seen that weith loss improved their symptoms.(107 uptodate) In the other hand higher level of leptin (a protein released from adipose tissue) was found in IHH patiets.(125)
-* Vitamin A intoxication: There are some evidences of higher serum and CSF level of vitamin A, retinol and retinol binding protein can be related to IHH pathogenesis.(116-118)
-* Sleep apnea: Sleep apnea can cause hypercarbia which can result in vasodilation and elevated intacranial pressure (74 uptodate)
-* Sex hormones: In one study regarding IIH etiology which was done on 8 men with this disease, Four of them had abnormal FSH and LH level, 2 of them had estradiol abnormalities and seven of them had reduced testosterone level.(127 uptodate)
+=== Common causes ===
+Pseudotumor cerebri may be caused by:
+* Intracranial venous outflow obstruction ([[Cerebral venous sinus thrombosis|venous sinus thrombosis]], [[head trauma]], [[polycythemia]], [[thrombocytosis]])
+* Endocrine dysfunction ([[obesity]], cessation of [[corticosteroid]] therapy, [[Addison's disease|Addison disease]], [[hypoparathyroidism]])
+* Vitamin/drug ([[growth hormone]], [[hypervitaminosis A]], [[tetracycline]], [[minocycline]], [[nalidixic acid]])
+* Other (chronic [[hypercapnia]], severe [[right heart failure]], chronic [[meningitis]], [[hypertensive encephalopathy]], severe [[iron deficiency anemia]])
+* [[Idiopathic]]<ref>Clinical Neurology 9E Aminoff</ref>
 ==References==

Pseudotumor cerebri causes: Difference between revisions

Latest revision as of 14:26, 29 November 2018

Overview

Causes

Common causes

References

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