Pseudo-Cushing's syndrome: Difference between revisions

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==[[Pseudo Cushing's syndrome overview|Overview]]==


==Overview==
==[[Pseudo Cushing's syndrome historical perspective|Historical Perspective]]==
'''Pseudo-Cushing's syndrome''' is a medical condition in which patients display the [[medical sign|signs]], [[symptom]]s, and abnormal [[hormone]] levels seen in [[Cushing's syndrome]].  Pseudo-Cushing's syndrome, however, is not caused by a problem with the [[hypothalamic-pituitary-adrenal axis]] as Cushing's is. It is an [[idiopathic]] condition.


==Investigations==
==[[Pseudo Cushing's syndrome classification|Classification]]==
*Levels of [[cortisol]] and [[ACTH]] are both high
*24-hour urinary cortisol levels are high
*[[Dexamethasone]] suppression test fails to suppress serum cortisol
*Loss of diurnal variation in cortisol levels- Loss of Diurnal Variation is seen only in true Cushing's Syndrome or Disease.
*High [[mean corpuscular volume]] and [[gamma-glutamyl transferase]] may be clues to [[alcoholism]]
* [[Polycystic Ovarian Syndrome]] should be ruled out, since PCOS has similar symptoms.


==Differential diagnosis==
*Differentiation from Cushing's is extremely difficult
*Causes of Cushing's should be excluded with imaging of the [[lung]]s, [[adrenal gland]]s, and [[pituitary gland]] - but these often appear normal in Cushing's anyway
*In the alcoholic patient with pseudo-Cushing's, admission to hospital (and avoidance of alcohol) will result in normal midnight cortisol levels within 5 days, excluding Cushing's<ref>{{cite journal | author=Newell-Price J, Trainer P, Besser M, Grossman A. | title=The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. | journal=Endocr Rev | volume=19 | issue=5 | pages=647-72 | year=1998 | id=PMID 9793762}}</ref>


==Prognosis==
==[[Pseudo Cushing's syndrome pathophysiology|Pathophysiology]]==
*Blood results and symptoms normalise rapidly on cessation of drinking or remission of depression


==References==
==[[Pseudo Cushing's syndrome causes|Causes]]==
{{Reflist|2}}
 
==[[Pseudo Cushing's syndrome differential diagnosis|Differentiating Pseudo Cushing's syndrome from other Diseases]]==
 
==[[Pseudo Cushing's syndrome epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Pseudo Cushing's syndrome risk factors|Risk Factors]]==
 
==[[Pseudo Cushing's syndrome screening|Screening]]==
 
==[[Pseudo Cushing's syndrome natural history|Natural History, Complications and Prognosis]]==
 
==[[Pseudo Cushing's syndrome diagnosis|Diagnosis]]==
[[Pseudo Cushing's syndrome history and symptoms|History and Symptoms]] | [[Pseudo Cushing's syndrome physical examination|Physical Examination]] | [[Pseudo Cushing's syndrome laboratory tests|Laboratory Findings]] | [[Pseudo Cushing's syndrome chest x ray|Chest X Ray]] | [[Pseudo Cushing's syndrome CT|CT]] | [[Pseudo Cushing's syndrome ultrasound|Ultrasound]] | [[Pseudo Cushing's syndrome other imaging findings|Other Imaging Findings]] | [[Pseudo Cushing's syndrome other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Pseudo Cushing's syndrome medical therapy|Medical Therapy]] | [[Pseudo Cushing's syndrome surgery|Surgery]] | [[Pseudo Cushing's syndrome primary prevention|Primary Prevention]] | [[Pseudo Cushing's syndrome secondary prevention|Secondary Prevention]] | [[Pseudo Cushing's syndrome cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Pseudo Cushing's syndrome future or investigational therapies|Future or Investigational Therapies]]
==Case Studies==
:[[Pseudo Cushing's syndrome case study one|Case #1]]


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Latest revision as of 22:44, 20 September 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Pseudo Cushing's syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1


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