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Revision as of 18:04, 20 September 2012

For patient information click here

Pseudo-Cushing's syndrome
ICD-10 E24.3

Pseudo Cushing's syndrome Microchapters

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Overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pseudo-Cushing's syndrome is a medical condition in which patients display the signs, symptoms, and abnormal hormone levels seen in Cushing's syndrome. Pseudo-Cushing's syndrome, however, is not caused by a problem with the hypothalamic-pituitary-adrenal axis as Cushing's is. It is an idiopathic condition.

Investigations

Differential diagnosis

  • Differentiation from Cushing's is extremely difficult
  • Causes of Cushing's should be excluded with imaging of the lungs, adrenal glands, and pituitary gland - but these often appear normal in Cushing's anyway
  • In the alcoholic patient with pseudo-Cushing's, admission to hospital (and avoidance of alcohol) will result in normal midnight cortisol levels within 5 days, excluding Cushing's[1]

Prognosis

  • Blood results and symptoms normalise rapidly on cessation of drinking or remission of depression

References

  1. Newell-Price J, Trainer P, Besser M, Grossman A. (1998). "The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states". Endocr Rev. 19 (5): 647–72. PMID 9793762.


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