Procollagen peptidase

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procollagen (type III) N-endopeptidase
Identifiers
SymbolPCOLN3
Alt. symbolsPRSM1
Entrez5119
HUGO8740
OMIM164010
RefSeqNM_002768
UniProtQ9HD42
Other data
EC number3.4.24.14
LocusChr. 16 q24.3

Procollagen peptidase (EC 3.4.24.14, procollagen N-terminal peptidase, procollagen aminopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, procollagen aminoterminal protease, procollagen N-terminal proteinase, type I/II procollagen N-proteinase, type III procollagen) is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome.[1]

The enzyme is present in the skin of rats and humans.[2]

External links

  • The MEROPS online database for peptidases and their inhibitors: Procollagen C-Peptidase:M12.005, Procollagen N-Peptidase:M12.301

References

  1. http://www.biology-online.org/dictionary/Procollagen_peptidase
  2. Lapière CM, Lenaers A, Kohn LD (December 1971). "Procollagen peptidase: an enzyme excising the coordination peptides of procollagen". Proceedings of the National Academy of Sciences of the United States of America. 68 (12): 3054–8. doi:10.1073/pnas.68.12.3054. PMC 389589. PMID 5289249.

External links