Primary cutaneous follicle centre lymphoma pathophysiology: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 8: Line 8:
==Genetics==
==Genetics==
Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:<ref name=cancer.gov> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>
Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:<ref name=cancer.gov> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>
* Amplification of [[C-REL]] gene
* Amplification of '''C-REL''' gene
* [[BCL]]-2 rearrangements
* '''BCL-2''' rearrangements


==Gross Pathology==
==Gross Pathology==

Revision as of 13:50, 2 March 2016

Primary cutaneous follicle centre lymphoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Primary cutaneous follicle centre lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Primary cutaneous follicle centre lymphoma pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Primary cutaneous follicle centre lymphoma pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Primary cutaneous follicle centre lymphoma pathophysiology

CDC on Primary cutaneous follicle centre lymphoma pathophysiology

Primary cutaneous follicle centre lymphoma pathophysiology in the news

Blogs on Primary cutaneous follicle centre lymphoma pathophysiology

Directions to Hospitals Treating Splenic marginal zone lymphoma

Risk calculators and risk factors for Primary cutaneous follicle centre lymphoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Pathophysiology

Genetics

Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:[1]

  • Amplification of C-REL gene
  • BCL-2 rearrangements

Gross Pathology

Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).[2]

Microscopic Pathology

Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).[2]



References

  1. Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016
  2. 2.0 2.1 Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7. Accessed on March 01, 2016


Template:WikiDoc Sources