Polydipsia: Difference between revisions

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'''For patient information page click [[{{PAGENAME}} (patient information)|here]]'''
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{{Infobox_Disease |
{{Infobox_Disease |
   Name        = Polydipsia |
   Name        = Polydipsia |
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   ICD9        = {{ICD9|783.5}} |
   ICD9        = {{ICD9|783.5}} |
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{{SI}}
{{Polydipsia}}
{{CMG}}


{{JFS}}
'''For patient information page click [[{{PAGENAME}} (patient information)|here]]'''
 
{{EH}}


==Overview==
{{CMG}}; {{JFS}}
'''Polydipsia''' is a medical condition in which the patient ingests abnormally large amounts of [[fluid]]s by mouth. The word is made from the words ''poly'' meaning many and ''dipsia'' which means [[thirst]]. The fluid is usually water, though some people may think of [[alcohol]] because of the etymologically related term [[dipsomaniac]], meaning an [[alcoholic]].


==Differential diagnosis of the causes of polydipsia==
==[[Polydipsia overview|Overview]]==
===Common causes===
Polydipsia is almost always associated with [[dehydration]] due to [[polyuria]] (excessive urination), if the condition is prolonged beyond a few hours in those with functioning kidneys.


It is often, and characteristically, found in [[diabetes mellitus|diabetics]], often as one of the initial symptoms, and in those who fail to take their anti-diabetic medications or whose dosages have become inadequate. It is also caused by other conditions featuring [[osmotic diuresis]] and by [[diabetes insipidus]] ("water diabetes"), and forms part of the differential diagnostic tree for them, as well. Polydipsia is also a symptom of [[atropine]] or [[deadly nightshade|belladonna]] poisoning. Another cause can be due to medication (such as [[diuretics]]) or inadvertent consumption of [[caffeine]]. One who drinks nothing but coffee or soda can be easily misdiagnosed by a medical professional as [[psychogenic polydipsia]], as they may be unaware they are consuming [[diuretics]].
==[[Polydipsia classification|Classification]]==


===Complete differential diagnosis of causes of polydipsia===
==[[Polydipsia pathophysiology|Pathophysiology]]==
(In alphabetical order)
[[Polydipsia polydipsia in psychiatric patients|Polydipsia in Psychiatric patients]]


*[[Beer potomania]]
==[[Polydipsia causes|Causes]]==
*[[Cushing syndrome]]
*[[Diabetes insipidus]]
**Nephrogenic [[diabetes insipidus]]
***[[Amyloidosis]] of the kidneys
***[[Amikacin]]
***[[Amphotericin B]]
***[[Bardet-Biedl syndrome]]
***[[Bartter syndrome]]
***[[Cystinosis]]
***[[Demeclocycline]]
***[[Diabetes insipidus]], congenital nephrogenic
***[Fanconi syndrome]]
***[[Gentamicin]]
***[[Hypercalcaemia]]
***[[Hypokalaemia]]
***[[Interstitial nephritis]]
***[[Kanamycin]]
***[[Lithium]]
***Loken Senior syndrome
***Medullary cystic renal disease
***[[Multiple myeloma]]
***[[Netilmicin]]
***[[Polycystic kidney disease]], adult (autosomal dominant)
***Proximal [[renal tubular acidosis]]
***[[Pyelonephritis]], acute
***[[Renal failure]], acute
***[[Renal failure]], chronic
***[[Sicca syndrome]]
***[[Sickle cell disease]]
***[[Urinary tract infection]]
**[[Central diabetes insipidus]]
***Arteriovenous malformations or [[aneurysms]]
***Cranial surgery
***[[Craniopharyngioma]]
***[[Cysts]]
***[[Cysticercosis]], cerebral
***DIDMOAD syndrome
***[[Erdheim-Chester disease]]
***Gestational diabetes insipidus
***[[Head injury]]
***[[Histiocytosis X]]
***[[Hydrocephalus]], obstructive
***Hypoxic encephalopathy
***Intracranial space-occupying lesion
***[[Leukemia]], acute
***[[Meningioma]]
***[[Meningoencephalitis]]
***[[Meningitis]]
***[[Metastatic]] brain disease
***pineal tumors
***[[Pituitary tumor]]
***Post encephalitis status
***[[Radiation therapy]]
***[[Sarcoidosis]]
***[[Sheehan syndrome]]
***[[Sickle cell disease]]
***[[Skull fracture]]
***[[Syphilis]]
***[[Tuberculosis]] 
***[[Tuberculoma]] of the hypothalamus
*[[Diabetes mellitus]] type 1 or type 2
*[[Hyperaldosteronism]]
*[[Hyperglycemia]]
*[[Hyperthyroidism]]
*[[Maturity onset diabetes of the young]]
*[[Medications]] especially diuretics. see also nephrogenic diabetes insipidus
**Bendrofluazide
**[[Bumetanide]]
**[[Conivaptan]]
**[[Furosemide]]
**[[Hydrochlorothiazide]]
**[[Lithium]]
**[[Vasopressin]]
**[[atropine]]
**[[deadly nightshade|belladonna]] poisoning
**[[caffeine]]
*[[Nephronophthisis]]
*[[Osmotic diuresis]]
**[[Diabetes mellitus]]
**[[Hyperglycaemia]]
**[[Isosorbide]]
**[[Mannitol]]
**[[Sorbitol]]
*[[Primary hyperparathyroidism]]
*[[Psychogenic polydipsia]]
*[[Sicca Syndrome]]
*[[Water intoxication]]


===Complete differential diagnosis of the causes of polydipsia===
==[[Polydipsia differential diagnosis|Differentiating Polydipsia from other Diseases]]==
(By organ system)
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | Arteriovenous malformations or [[aneurysms]] (vascular)
|-
|-bgcolor="LightSteelBlue"
| '''Chemical / poisoning'''
|bgcolor="Beige"| [[deadly nightshade|belladonna]] poisoning,
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| Bendrofluazide, [[Bumetanide]], [[Conivaptan]], Frusemide,[[Hydrochlorothiazide]], [[Lithium]], [[Vasopressin]], [[atropine]], [[deadly nightshade|belladonna]] poisoning, [[caffeine]], [[Amikacin]], [[Amphotericin B]],[[Demeclocycline]], [[Gentamicin]]
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Cushing syndrome]], [[Primary hyperparathyroidism]], [[Hyperglycemia]]
[[Diabetes insipidus]], [[Water intoxication]], [[Hyperthyroidism]], Maturity onset diabetes of the young, [[Diabetes mellitus]], [[Antidiuretic Hormone]]
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"|[[Polycystic kidney disease]](autosomal dominant), Congenital nephrogenic[[Diabetes insipidus]], [[Bardet-Biedl syndrome]], [[Sickle cell disease]], DIDMOAD syndrome, [[Fanconi syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| [[Sickle cell disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| [[Radiation therapy]]
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[meningoencephalitis]], [[Syphilis]], [[Tuberculosis]], [[Meningitis]], [[Cysticercosis]] (cerebral), Post encephalitis status, [[Tuberculoma]] of the hypothalamus
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal / Ortho'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"|[[Craniopharyngioma]], Pineal tumors, Hypoxic encephalopathy, [[Pituitary tumour]], [[Metastatic]] brain disease, [[Meningioma]], [[Hydrocephalus]] (obstructive), 
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional / Metabolic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| Gestational diabetes insipidus, [[Sheehan syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| pineal tumors, [[Craniopharyngioma]], [[Histiocytosis X]],[[Pituitary tumour]], [[Leukemia]](acute), [[Metastatic]] brain disease, [[Meningioma]]


|-
==[[Polydipsia epidemiology and demographics|Epidemiology and Demographics]]==
|-bgcolor="LightSteelBlue"
| '''Opthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose / Toxicity'''
|bgcolor="Beige"| [[Beer potomania]], Water intoxication
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| [[Psychogenic polydipsia]], [[Beer potomania]]
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal / Electrolyte'''
|bgcolor="Beige"| [[Bardet-Biedl syndrome]],[[Bartter syndrome]],[[Cystinosis]], Congenital nephrogenic[[Diabetes insipidus]], [[Hypercalcaemia]], [[Hypokalaemia]], [[Interstitial nephritis]], Loken Senior syndrome, Medullary cystic renal disease, [[Polycystic kidney disease]](autosomal dominant), Proximal [[renal tubular acidosis]],[[Pyelonephritis]],[[Renal failure]], [[Urinary tract infection]]
|-
|-bgcolor="LightSteelBlue"
| '''Rheum / Immune / Allergy'''
|bgcolor="Beige"| [[Sarcoidosis]], [[Amyloidosis]]
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| [[Head trauma]], [[Skull fracture]]
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| [[Sarcoidosis]], [[Histiocytosis X]]


|-
==[[Polydipsia risk factors|Risk Factors]]==
|}


===Polydipsia in Psychiatric Subsets===
==[[Polydipsia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
[[Psychogenic polydipsia]] is a type of polydypsia with described in patients with mental illnesses and/or the developmentally disabled. It is present in a subset of schizophrenics.  These patients, most often chronic schizophrenics with a long history of illness, often exhibit enlarged ventricles and shrunken cortex on MRI, making the physiological mechanism difficult to isolate from the psychogenic.  It is a serious disorder and often leads to institutionalization as it can be very difficult to manage outside the inpatient setting.  It should be taken very seriously - it can be life threatening as serum sodium is diluted to an extent that seizures and cardiac arrest can occur.  Patients have been known to seek fluids from any source possible. 
 
In treatment resistant polydipsic psychiatric patients, regulation in the inpatient milieau can be accomplished by use of a weight-water protocol.  First, baseline weights must be established and correlated to serum sodium levels.  Weight will normally fluctuate during the day, but as the water intake of the polydipsic goes up, the weight will naturally rise.  The physician can order a stepped series of interventions as the weight rises.  The correlation must be individualized with attention paid to the patient's normal weight and fluctuations, diet, co-morbid disorders (such as a seizure disorder) and urinary system functioning.  Progressive steps might include redirection, room restriction, and increasing levels of physical restraint with monitoring.  Such plans should also progressive increases in monitoring, as well as a level at which a serum sodium level is drawn.
 
It is important to note that the majority of psychotropic drugs (as well as many of other classes) can cause dry mouth, but this is not to be confused with true polydipsia in which a dangerous drop in serum sodium will be seen.
 
While psychogenic polydipsia is generally not found outside the population of those with serious mental disorders, there is some anecdotal evidence of a milder form (typically called 'habit polydispsia' or 'habit drinking') that can occasionally be found in the absence of psychosis or other mental conditions. The excessive levels of fluid intake may result in a false diagnosis of [[diabetes insipidus]], since the chronic ingestion of excessive water can produce diagnostic results that closely mimic those of mild diabetes insipidus.


==Diagnosis==
==Diagnosis==


Polydipsia is a symptom, not a disease (cause). To diagnose the cause of polydipsia a [[fluid deprivation test]] is used, which may require a patient to abstain from water, and for blood and urine tests to be undertaken. Additional blood work may be required to test for the presence of [[diuretics]], such as [[caffeine]], or recreational drugs. Finally neurological testing may be required to determine if there has been damage to the [[hypothalamus]] ( central diabetes insipidus).  These tests are routinally used in diagnosing diabetes insipidus.
[[Polydipsia history and symptoms|History and Symptoms ]] | [[ Polydipsia physical examination|Physical Examination]] | [[Polydipsia laboratory findings|Laboratory Findings]] | [[Polydipsia CT|CT]] | [[Polydipsia MRI|MRI]] | [[Polydipsia ultrasound|Ultrasound]] | [[Polydipsia other imaging findings|Other Imaging Findings]] | [[Polydipsia other diagnostic studies|Other Diagnostic Studies]]
 
== Treatment==
 
Most patients with diabetes insipidus (DI) can drink enough fluid to replace their urine losses. Losses can also be replaced with dextrose and water or IV fluid hyposmolar to the patient's serum. During replacement, avoid volume overload and a correction of hypernatremia that is too rapid. A good rule of thumb is to reduce serum sodium by 0.5 mmol/L/h. Water deficit may be calculated based on the assumption that body water is approximately 60% of body weight in kilograms.
In case of inadequate thirst, desmopressin is the drug of choice. Generally, it can be administered 2-3 times per day. Patients may require hospitalization to establish fluid needs. Frequent electrolyte monitoring is recommended.
Vasopressin or desmopressin acetate, modified  synthetic forms of antidiuretic hormone, may be taken as a nasal spray several times a day, to maintain a normal urine output. However, taking too much of this medication can cause fluid retention and swelling and other problems.
Sometimes diabetes insipidus can be controlled with drugs that stimulate  production of antidiuretic hormone such as [[chlorpropamide]], [[carbamazepine]], [[clofibrate]].
If nephrogenic DI is caused by medication (for example, lithium), stopping the medication may help restore normal kidney function. However, after many years of lithium use, the nephrogenic DI may be permanent.
Hereditary nephrogenic DI and lithium-induced nephrogenic DI are treated by drinking enough fluids to match urine output and with drugs that lower urine output. Drugs used to treat nephrogenic DI include: Anti-inflammatory medication (indomethacin)and Diuretics (hydrochlorothiazide (HCTZ) and amiloride). 
 


==Treatment==
[[Polydipsia medical therapy|Medical Therapy]] | [[Polydipsia secondary prevention|Secondary Prevention]] | [[Polydipsia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Polydipsia future or investigational therapies|Future or Investigational Therapies]]


==Case Studies==
[[Polydipsia case study one|Case #1]]


[[User:Johnfanisrour|Johnfanisrour]] 19:14, 25 January 2009 (UTC) John Fani Srour [[User:Johnfanisrour|Johnfanisrour]] 19:14, 25 January 2009 (UTC)


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[[Category:Endocrinology]]
[[Category:Endocrinology]]
[[Category:Symptoms]]
[[Category:Signs and symptoms]]
[[Category:Signs and symptoms]]
[[Category:Nephrology]]
[[Category:Nephrology]]

Latest revision as of 15:30, 12 June 2015

Polydipsia
ICD-10 R63.1
ICD-9 783.5

Polydipsia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: John Fani Srour, M.D.

Overview

Classification

Pathophysiology

Polydipsia in Psychiatric patients

Causes

Differentiating Polydipsia from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1


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