Plasminogen activator inhibitor-2

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serpin peptidase inhibitor, clade B (ovalbumin), member 2
Identifiers
SymbolSERPINB2
Alt. symbolsPLANH2, PAI2
Entrez5055
HUGO8584
OMIM173390
RefSeqNM_002575
UniProtP05120
Other data
LocusChr. 18 q21.3

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Overview

Plasminogen activator inhibitor-2 (placental PAI) is a coagulation factor which inactivates tPA & urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60 kDa extracellular glycosylated form and a 43 kDa intracellular form.

Fibrinolysis (simplified). Blue arrows denote stimulation, and red arrows inhibition.

It is only present at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosis during pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

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