Pineal embryonal carcinoma: Difference between revisions

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*On microscopic histopathological analysis, pineal embryonal carcinoma is characterized by:  
*On microscopic histopathological analysis, pineal embryonal carcinoma is characterized by:  
**Poorly differentiated, pleomorphic cells in cords, sheets, or papillary formation
**Poorly differentiated, pleomorphic cells in cords, sheets, or papillary formation
**Indistinct cell borders
**[[Nucleoli]] - key feature
**[[Nucleoli]] - key feature
**Vesicular nuclei (clear, empty appearing nuclei) - key feature
**Vesicular nuclei (clear, empty appearing nuclei) - key feature
**[[Necrosis]] - common
**[[Necrosis]] - common
**Indistinct cell borders
**[[Mitoses]] - common
**[[Mitoses]] - common
**Variable architecture:
**Variable architecture:

Revision as of 19:14, 4 December 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Synonyms and keywords:

Overview

  • Pineal embryonal carcinoma is a relatively rare malignant neoplasm and accounts for a small prportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. A component of embryonal carcinoma is often found in mixed germ-cell tumours, in which case it usually the most aggressive component, and dictates prognosis. Pure pineal embryonal carcinoma tumors do not secrete β-HCG or AFP.[1]
  • On microscopic histopathological analysis, pineal embryonal carcinoma is characterized by:
    • Poorly differentiated, pleomorphic cells in cords, sheets, or papillary formation
    • Indistinct cell borders
    • Nucleoli - key feature
    • Vesicular nuclei (clear, empty appearing nuclei) - key feature
    • Necrosis - common
    • Mitoses - common
    • Variable architecture:
      • Solid (predominant in ~55% of cases)
      • Glandular (predominant in ~17% of cases)
      • Papillary (predominant in ~11% of cases)
      • Nested
      • Micropapillary
      • Anastomosing glandular
      • Sieve-like glandular
      • Pseudopapillary
      • Blastocyst-like
      • Embryoid bodies - ball of cells in surrounded by empty space on three sides

References

  1. Intracranial embryonal carcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-embryonal-carcinoma. Accessed on December 4, 2015


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