https://www.wikidoc.org/index.php?title=Pinacidil&feed=atom&action=history
Pinacidil - Revision history
2024-03-29T06:11:08Z
Revision history for this page on the wiki
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WikiBot: Protected "Pinacidil": Bot: Protecting all pages from category Drug ([Edit=Allow only administrators] (indefinite) [Move=Allow only administrators] (indefinite))
2015-08-20T16:57:05Z
<p>Protected "<a href="/index.php/Pinacidil" title="Pinacidil">Pinacidil</a>": Bot: Protecting all pages from category Drug ([Edit=Allow only administrators] (indefinite) [Move=Allow only administrators] (indefinite))</p>
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<td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:57, 20 August 2015</td>
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WikiBot
https://www.wikidoc.org/index.php?title=Pinacidil&diff=1001015&oldid=prev
GeraldChi at 00:26, 25 July 2014
2014-07-25T00:26:35Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 00:26, 25 July 2014</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Overview==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Overview==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Pinacidil''' is a <del style="font-weight: bold; text-decoration: none;">[[2-</del>cyanoguanidine<del style="font-weight: bold; text-decoration: none;">|cyanoguanidine]] </del>drug that opens [[ATP-sensitive potassium channel]]s producing peripheral [[vasodilatation]] of [[arteriole]]s.<ref name="pmid7473155">{{cite journal | author = Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H | title = Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells | journal = J. Pharmacol. Exp. Ther. | volume = 275 | issue = 2 | pages = 681–92 | year = 1995 | pmid = 7473155 | doi = | url = http://jpet.aspetjournals.org/cgi/content/abstract/275/2/681 | issn = }}</ref> It reduces [[blood pressure]] and peripheral resistance and produces fluid retention.<ref name="isbn0-85369-342-0">{{cite book | author = Reynolds, James Blair; Martindale, William L. | title = The extra pharmacopoeia | publisher = Royal Pharmaceutical Society | location = London | year = 1996 | edition = 31st | pages = 2739 pages | isbn = 0-85369-342-0 | oclc = | doi = }}</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Pinacidil''' is a cyanoguanidine drug that opens [[ATP-sensitive potassium channel]]s producing peripheral [[vasodilatation]] of [[arteriole]]s.<ref name="pmid7473155">{{cite journal | author = Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H | title = Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells | journal = J. Pharmacol. Exp. Ther. | volume = 275 | issue = 2 | pages = 681–92 | year = 1995 | pmid = 7473155 | doi = | url = http://jpet.aspetjournals.org/cgi/content/abstract/275/2/681 | issn = }}</ref> It reduces [[blood pressure]] and peripheral resistance and produces fluid retention.<ref name="isbn0-85369-342-0">{{cite book | author = Reynolds, James Blair; Martindale, William L. | title = The extra pharmacopoeia | publisher = Royal Pharmaceutical Society | location = London | year = 1996 | edition = 31st | pages = 2739 pages | isbn = 0-85369-342-0 | oclc = | doi = }}</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==References==</div></td></tr>
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GeraldChi
https://www.wikidoc.org/index.php?title=Pinacidil&diff=1001013&oldid=prev
GeraldChi at 00:21, 25 July 2014
2014-07-25T00:21:48Z
<p></p>
<p><b>New page</b></p><div>{{Chembox new<br />
| ImageFile = Pinacidil.png<br />
| ImageSize = <br />
| IUPACName = 3-cyano-1-(4-pyridyl)-2-(1,2,2-trimethylpropyl)guanidine<br />
| OtherNames =<br />
| Section1 = {{Chembox Identifiers<br />
| CASNo=85371-64-8<br />
| PubChem=4826<br />
| SMILES=CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1<br />
}}<br />
| Section2 = {{Chembox Properties<br />
| Formula=C<sub>13</sub>H<sub>19</sub>N<sub>5</sub><br />
| MolarMass=245.32346<br />
| Appearance=<br />
| Density=<br />
| MeltingPt=<br />
| BoilingPt=<br />
| Solubility=<br />
}}<br />
| Section3 = {{Chembox Hazards<br />
| MainHazards=<br />
| FlashPt=<br />
| Autoignition=<br />
}}<br />
}}<br />
__NOTOC__<br />
{{SI}}<br />
{{CMG}}<br />
<br />
==Overview==<br />
<br />
'''Pinacidil''' is a [[2-cyanoguanidine|cyanoguanidine]] drug that opens [[ATP-sensitive potassium channel]]s producing peripheral [[vasodilatation]] of [[arteriole]]s.<ref name="pmid7473155">{{cite journal | author = Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H | title = Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells | journal = J. Pharmacol. Exp. Ther. | volume = 275 | issue = 2 | pages = 681–92 | year = 1995 | pmid = 7473155 | doi = | url = http://jpet.aspetjournals.org/cgi/content/abstract/275/2/681 | issn = }}</ref> It reduces [[blood pressure]] and peripheral resistance and produces fluid retention.<ref name="isbn0-85369-342-0">{{cite book | author = Reynolds, James Blair; Martindale, William L. | title = The extra pharmacopoeia | publisher = Royal Pharmaceutical Society | location = London | year = 1996 | edition = 31st | pages = 2739 pages | isbn = 0-85369-342-0 | oclc = | doi = }}</ref><br />
<br />
==References==<br />
{{Reflist|2}}<br />
<br />
==External links==<br />
* {{MeshName|Pinacidil}}<br />
<br />
[[Category:Antihypertensive agents]]<br />
[[Category:Cardiovascular Drugs]]<br />
[[Category:Drug]]<br />
[[Category:Vasodilators]]</div>
GeraldChi