Phosphate nephropathy: Difference between revisions
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===Chronic Kidney disease=== | ===Chronic Kidney disease=== | ||
A patient suffering from chronic kidney disease will have a decreased glomerular filtration rate (GFR). This will further increase the risk of hyperphosphatemia following OSP administration and hence worsen the situation. | |||
===Hypertension=== | ===Hypertension=== | ||
===Drugs=== | ===Drugs=== |
Revision as of 17:55, 10 June 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayesha Javid, MBBS[2]
Overview
Acute phosphate nephropathy is a form of renal injury that occurs as a result of consumption of bowel purgatives which contain oral sodium phosphate (OSP). It can lead to acute kidney injury followed by chronic renal failure. OSP is a commonly used purgative especially before colonoscopy.
Pathophysiology
Causes
Epidemiology and Demographics
Gender
Several studies report, the majority of cases of acute phosphate nephropathy in the female gender. It could be related to their smaller heights and subsequently less GFR as compared to men.
Age
Several epidemiological studies have identified advanced age as an independent risk factor of acute phosphate nephropathy. Mean age of 64 years has been identified.
Ethnicity
A higher prevalence has been seen in whites.
Risk Factors
Advanced age
Dose of Oral Sodium Phosphate administered
The risk of acute phosphate nephropathy is directly related to the dose of Oral Sodium Phosphate (OSP) administered. The higher the dose administered, more will be blood phosphate levels and hence there would be a higher chance of harming kidneys and resulting in nephropathy.[1]
Chronic Kidney disease
A patient suffering from chronic kidney disease will have a decreased glomerular filtration rate (GFR). This will further increase the risk of hyperphosphatemia following OSP administration and hence worsen the situation.
Hypertension
Drugs
Diabates mellitus
Female gender
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria | History and Symptoms | Physical Examination | Laboratory Findings | Phosphate Nephropathy Biopsy | X ray | Ultrasound | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
References
- ↑ Vanner SJ, MacDonald PH, Paterson WG, Prentice RS, Da Costa LR, Beck IT (1990). "A randomized prospective trial comparing oral sodium phosphate with standard polyethylene glycol-based lavage solution (Golytely) in the preparation of patients for colonoscopy". Am J Gastroenterol. 85 (4): 422–7. PMID 2183591 PMID 2183591 Check
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