Paroxysmal nocturnal hemoglobinuria history and symptoms: Difference between revisions

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Revision as of 18:42, 23 October 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Patients with PNH may have a positive history of:

Common symptoms of [PNH] include:

Due to hemolysis
1. fatigue
2. dyspnea
3. dark (red/pink/black) colored urine
4. jaundice

Due to nitric oxide depletion
1. dysphagia
2. chest pain from esophageal spasm
3. abdominal pain
4. erectile dysfunction

Less common symptoms of [PNH] include

@@ Line 4: / Line 4: @@
 {{CMG}}; {{AE}}
 ==Overview==
-The majority of patients with [disease name] are asymptomatic.
-OR
-The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
 ==History and Symptoms==
-*There is no single hallmark symptom of [PNH]. [PNH] is associated with a wide range of symptoms.
 ===History===
-Patients with [PNH]] may have a positive history of:
+Patients with PNH may have a positive history of:
-* feeling tired/ weak
+* Feeling tired/ weak
-* shortness of breath
+* Shortness of breath
-* dark (red/pink/black) colored urine
+* Dark colored urine
-* jaundice
+* Jaundice
-* blood clots
+* Blood clots
-* difficulty swallowing
+* Difficulty swallowing
-* chest pain
+* Chest pain
-* abdominal pain
+* Abdominal pain
-* headaches
+* Headaches
-* confusion
+* Confusion
-* dysphagia
+* Dysphagia
-* erectile dysfunction
+* Erectile dysfunction
-* low blood cell counts
+* Low blood cell counts
-* iron deficiency
+* Iron deficiency
-* kidney problems: acute or chronic insufficiency
 ===Common Symptoms===