Paroxysmal nocturnal hemoglobinuria history and symptoms: Difference between revisions

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{{Paroxysmal nocturnal hemoglobinuria}}
{{Paroxysmal nocturnal hemoglobinuria}}


{{CMG}}; {{AE}}  
{{CMG}}; {{AE}} {{AEL}}  
==Overview==
==Overview==
The majority of patients with [disease name] are asymptomatic.
Common symptoms of paroxysmal nocturnal hemoglobinuria include fatigue, [[dyspnea]], [[headaches]], [[abdominal pain]], [[dysphagia]] and [[chest pain]]. Less common symptoms may include necrotic skin lesions.  
 
OR
 
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].


==History and Symptoms==
==History and Symptoms==
*There is no single hallmark symptom of [PNH]. [PNH] is associated with a wide range of symptoms.
===History===
===History===
Patients with [PNH]] may have a positive history of:
Patients with PNH may have a positive history of:
* feeling tired/ weak
* Feeling tired/ weak
* shortness of breath
* Shortness of breath
* dark (red/pink/black) colored urine  
* Dark colored urine  
* jaundice
* Jaundice
* blood clots
* Blood clots
* difficulty swallowing
* Difficulty swallowing
* chest pain
* Chest pain
* abdominal pain
* Abdominal pain
* headaches
* Headaches
* confusion
* Confusion
* dysphagia
* Dysphagia
* erectile dysfunction
* [[Erectile dysfunction]]
* low blood cell counts
* Low blood cell counts
* iron deficiency
* Iron deficiency
* kidney problems: acute or chronic insufficiency


===Common Symptoms===
===Common Symptoms===
Common symptoms of [PNH] include:
Common symptoms of PNH include:<ref name="pmid16051736">{{cite journal| author=Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R et al.| title=Diagnosis and management of paroxysmal nocturnal hemoglobinuria. | journal=Blood | year= 2005 | volume= 106 | issue= 12 | pages= 3699-709 | pmid=16051736 | doi=10.1182/blood-2005-04-1717 | pmc=1895106 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16051736  }}</ref>
* Due to hemolysis   
* Due to hemolysis   
*# fatigue
*# Fatigue
*# dyspnea
*# Dyspnea
*# dark (red/pink/black) colored urine
*# Jaundice
*# jaundice


* Due to thrombosis
* Due to thrombosis:
*# headaches
*# Headaches
*# confusion
*# Confusion
*# abdominal pain
*# Abdominal pain
*# chest pain
*# Chest pain


* Due to nitric oxide depletion
* Due to [[nitric oxide]] depletion:
*# dysphagia
*# [[Dysphagia]]
*# chest pain from esophageal spasm
*# [[Chest pain]]
*# abdominal pain
*# [[Abdominal pain]]
*# erectile dysfunction
*# Erectile dysfunction


===Less Common Symptoms===
===Less Common Symptoms===
Less common symptoms of [PNH] include  
Less common symptoms of PNH include
* necrotic skin lesions
* [[Necrotic]] [[skin]] lesions
* abdominal fullness/ distension


==References==
==References==

Latest revision as of 21:30, 1 November 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Common symptoms of paroxysmal nocturnal hemoglobinuria include fatigue, dyspnea, headaches, abdominal pain, dysphagia and chest pain. Less common symptoms may include necrotic skin lesions.

History and Symptoms

History

Patients with PNH may have a positive history of:

  • Feeling tired/ weak
  • Shortness of breath
  • Dark colored urine
  • Jaundice
  • Blood clots
  • Difficulty swallowing
  • Chest pain
  • Abdominal pain
  • Headaches
  • Confusion
  • Dysphagia
  • Erectile dysfunction
  • Low blood cell counts
  • Iron deficiency

Common Symptoms

Common symptoms of PNH include:[1]

  • Due to hemolysis
    1. Fatigue
    2. Dyspnea
    3. Jaundice
  • Due to thrombosis:
    1. Headaches
    2. Confusion
    3. Abdominal pain
    4. Chest pain

Less Common Symptoms

Less common symptoms of PNH include:

References

  1. Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.

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