Parotitis future or investigational therapies: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Parotitis}} | {{Parotitis}} | ||
{{CMG}} {{AE}} {{LRO}} | |||
==Overview== | |||
[[Aprotinin]], a [[kallikrein]] inhibitor, is currently being investigated for treatment of chronic parotitis symptoms. Initial studies have demonstrated its potential to relieve pain, restore normal [[parotid gland]] function, and resolve [[parotid gland]] swelling. Further research is warranted. | |||
==Future or Investigational Therapies== | |||
*[[Aprotinin]], a [[kallikrein]] inhibitor, is currently being investigated for treatment of chronic parotitis symptoms.<ref name="pmid2416305">{{cite journal |vauthors=Maier H, Adler D, Lenarz T, Müller-Esterl W |title=New concepts in the treatment of chronic recurrent parotitis |journal=Arch Otorhinolaryngol |volume=242 |issue=3 |pages=321–8 |year=1985 |pmid=2416305 |doi= |url=}}</ref> | |||
**[[Kallikrein]] release in the [[parotid gland]] is associated with the [[inflammatory]] [[edema]] process. | |||
**[[Aprotinin]] was administered to 7 recurrent parotitis patients, with the following results observed: | |||
***Pain relieved 12 hours after administration | |||
***[[Parotid gland]] function returned to normal 48 hours after administration | |||
***[[Parotid gland]] swelling resolved after 7 days. | |||
*More research is warranted on the efficacy of [[kallikrein]] inhibition. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Glands]] | [[Category:Glands]] | ||
[[Category:Inflammations]] | [[Category:Inflammations]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 18:38, 18 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Aprotinin, a kallikrein inhibitor, is currently being investigated for treatment of chronic parotitis symptoms. Initial studies have demonstrated its potential to relieve pain, restore normal parotid gland function, and resolve parotid gland swelling. Further research is warranted.
Future or Investigational Therapies
- Aprotinin, a kallikrein inhibitor, is currently being investigated for treatment of chronic parotitis symptoms.[1]
- Kallikrein release in the parotid gland is associated with the inflammatory edema process.
- Aprotinin was administered to 7 recurrent parotitis patients, with the following results observed:
- Pain relieved 12 hours after administration
- Parotid gland function returned to normal 48 hours after administration
- Parotid gland swelling resolved after 7 days.
- More research is warranted on the efficacy of kallikrein inhibition.