Parathyroid disorders: Difference between revisions
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| Line 45: | Line 45: | ||
| style="background: #F5F5F5; text-align: center;" |'''↑''' | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" |'''↓'''/Normal | | style="background: #F5F5F5; text-align: center;" |'''↓'''/Normal | ||
| style="background: #F5F5F5; |Normal/'''↑''' calcitriol | | style="background: #F5F5F5; " |Normal/'''↑''' calcitriol | ||
|- | |- | ||
| style="background: #DCDCDC; text-align: center;" |Secondary hyperparathyroidism | | style="background: #DCDCDC; text-align: center;" |Secondary hyperparathyroidism | ||
| Line 51: | Line 51: | ||
| style="background: #F5F5F5; text-align: center;" |'''↓'''/Normal | | style="background: #F5F5F5; text-align: center;" |'''↓'''/Normal | ||
| style="background: #F5F5F5; text-align: center;" |'''↑''' | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" |-- | | style="background: #F5F5F5; text-align: center;" | -- | ||
|- | |- | ||
| style="background: #DCDCDC; text-align: center;" |Tertiary hyperparathyroidism | | style="background: #DCDCDC; text-align: center;" |Tertiary hyperparathyroidism | ||
| Line 57: | Line 57: | ||
| style="background: #F5F5F5; text-align: center;" |'''↑''' | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" |'''↑''' | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" |-- | | style="background: #F5F5F5; text-align: center;" | -- | ||
|- | |- | ||
| colspan="2" style="background: #DCDCDC; text-align: center;" |Familial hypocalciuric hypercalcemia | | colspan="2" style="background: #DCDCDC; text-align: center;" |Familial hypocalciuric hypercalcemia | ||
| style="background: #F5F5F5; text-align: center;" |Normal/'''↑''' | | style="background: #F5F5F5; text-align: center;" |Normal/'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" |Normal/'''↑''' | | style="background: #F5F5F5; text-align: center;" |Normal/'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" |-- | | style="background: #F5F5F5; text-align: center;" | -- | ||
| style="background: #F5F5F5;|'''↓''' Urinary calcium/creatinine clearance ratio | | style="background: #F5F5F5;" |'''↓''' Urinary calcium/creatinine clearance ratio | ||
|- | |- | ||
| colspan="2" style="background: #DCDCDC; text-align: center;" |Hypoparathyroidism | | colspan="2" style="background: #DCDCDC; text-align: center;" |Hypoparathyroidism | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↓''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↓''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; | | | style="background: #F5F5F5; " | | ||
*'''↓''' [[1,25-dihydroxy vitamin D|1,25 Dihydroxy vitamin D]] | |||
*Normal [[urinary]] [[cAMP]] | |||
*Normal [[urinary]] [[phosphate]] | |||
|- | |- | ||
| rowspan="5" style="background: #DCDCDC; text-align: center;" |Pseudohypoparathyroidism | | rowspan="5" style="background: #DCDCDC; text-align: center;" |Pseudohypoparathyroidism | ||
| style="background: #DCDCDC; text-align: center;" | Pseudohypoparathyroidism type 1A | | style="background: #DCDCDC; text-align: center;" | Pseudohypoparathyroidism type 1A | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↓''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; | | | style="background: #F5F5F5; " | | ||
*'''↓''' [[1,25-dihydroxy vitamin D|1,25 Dihydroxy vitamin D]] | |||
*'''↓''' [[Urinary]] [[cAMP]] | |||
*'''↓''' [[Urinary System|Urinary]] [[phosphate]] | |||
|- | |- | ||
| style="background: #DCDCDC; text-align: center;" | Pseudohypoparathyroidism type 1B | | style="background: #DCDCDC; text-align: center;" | Pseudohypoparathyroidism type 1B | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↓''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; | | | style="background: #F5F5F5; " | | ||
*'''↓''' [[1,25-dihydroxy vitamin D|1,25 Dihydroxy vitamin D]] | |||
*'''↓''' [[Urinary]] [[cAMP]] | |||
*'''↓''' [[Urinary System|Urinary]] [[phosphate]] | |||
|- | |- | ||
| style="background: #DCDCDC; text-align: center;" | Pseudohypoparathyroidism type 1C | | style="background: #DCDCDC; text-align: center;" | Pseudohypoparathyroidism type 1C | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↓''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; | | | style="background: #F5F5F5; " | | ||
*'''↓''' [[1,25-dihydroxy vitamin D|1,25 Dihydroxy vitamin D]] | |||
*'''↓''' [[Urinary]] [[cAMP]] | |||
*'''↓''' [[Urinary System|Urinary]] [[phosphate]] | |||
|- | |- | ||
| style="background: #DCDCDC; text-align: center;" | Pseudopseudohypoparathyroidism | | style="background: #DCDCDC; text-align: center;" | Pseudopseudohypoparathyroidism | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↓''' | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |'''↑''' | ||
| style="background: #F5F5F5; | | | style="background: #F5F5F5; " | | ||
*'''↓''' '''↓''' [[1,25-dihydroxy vitamin D|1,25 Dihydroxy vitamin D]] | |||
*Normal [[urinary]] [[cAMP]] | |||
*'''↓''' [[Urinary]] [[phosphate]] | |||
|- | |- | ||
| style="background: #DCDCDC; text-align: center;" | Pseudohypoparathyroidism type 2 | | style="background: #DCDCDC; text-align: center;" | Pseudohypoparathyroidism type 2 | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |Normal | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |Normal | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" |Normal | ||
| style="background: #F5F5F5; | | | style="background: #F5F5F5; " | -- | ||
|- | |- | ||
| style="background: #DCDCDC; text-align: center;" | | | style="background: #DCDCDC; text-align: center;" | | ||
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| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" | | ||
| style="background: #F5F5F5; text-align: center;" | | | style="background: #F5F5F5; text-align: center;" | | ||
| style="background: #F5F5F5; | | | style="background: #F5F5F5; " | | ||
|} | |} | ||
==Differentiating Parathyroid Disorders== | ==Differentiating Parathyroid Disorders== | ||
Revision as of 19:18, 5 October 2017
|
Parathyroid disorders |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Usama Talib, BSc, MD [2]
Synonyms and keywords:
Overview
Classification
| Parathyroid disorders | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Hyperparathyroidism | Familial hypocalciuric hypercalcemia | Hypoparathyroidism | Parathyroid hormone resistance diseases | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Primary | Secondary | Tertiary | Post-surgical | Autoimmune | Genetic defects associated | Functional | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pseudohypoparathyroidism | Acrodysostosis | Blomstrand chondrodysplasia | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pseudohypoparathyroidism type 1 | Pseudohypoparathyroidism type 2 | Acrodysostosis type 1 | Acrodysostosis type 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type 1A | Type 1B | Type 1C | Pseudopseudohypoparathyroidism | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Diagnosis
| Disorder | Laboratory findings | ||||
|---|---|---|---|---|---|
| Parathyroid hormone | Serum calcium | Serum phosphate | Other findings | ||
| Hyperparathyroidism | Primary hyperparathyroidism | ↑ | ↑ | ↓/Normal | Normal/↑ calcitriol |
| Secondary hyperparathyroidism | ↑ | ↓/Normal | ↑ | -- | |
| Tertiary hyperparathyroidism | ↑ | ↑ | ↑ | -- | |
| Familial hypocalciuric hypercalcemia | Normal/↑ | Normal/↑ | -- | ↓ Urinary calcium/creatinine clearance ratio | |
| Hypoparathyroidism | ↓ | ↓ | ↑ |
| |
| Pseudohypoparathyroidism | Pseudohypoparathyroidism type 1A | ↑ | ↓ | ↑ | |
| Pseudohypoparathyroidism type 1B | ↑ | ↓ | ↑ | ||
| Pseudohypoparathyroidism type 1C | ↑ | ↓ | ↑ | ||
| Pseudopseudohypoparathyroidism | ↑ | ↓ | ↑ |
| |
| Pseudohypoparathyroidism type 2 | Normal | Normal | Normal | -- | |