Palmar plantar erythrodysesthesia differential diagnosis: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
|||
| Line 7: | Line 7: | ||
==Differentiating palmar plantar erythrodysesthesia from other Diseases== | ==Differentiating palmar plantar erythrodysesthesia from other Diseases== | ||
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | {| style="border: 0px; font-size: 90%; margin: 3px;" align=center | ||
| Line 16: | Line 14: | ||
! align="center" style="background:#4479BA; color: #FFFFFF;" + |Additional diagnostic clues | ! align="center" style="background:#4479BA; color: #FFFFFF;" + |Additional diagnostic clues | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | | | style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | Palmar plantar erythrodysesthesia | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | | | style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | The areas of well-defined intense erythema and edema | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | | | style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | | * A variable degree of epidermal (keratinocytes) necrosis | ||
* Vacuolar degeneration of the basal cell layer of epidermis | |||
* Spongiosis | |||
* Hyperkeratosis | |||
* Lymphohistiocytic infiltrates | |||
* Superficial perivascular infiltration of dermis by lymphocytes and eosinophils | |||
* Papillary dermal edema | |||
* Neutrophilic eccrine hidradenitis | |||
* Eccrine squamous syringometaplasia, in severe PPE (WHO grades 3 and 4) | |||
| style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | History of chemotherapeutic agent use | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | x1 | | style="background: #DCDCDC; padding: 5px; text-align: center;" valign="top" | x1 | ||
Revision as of 23:04, 30 July 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D. [2]
Overview
PPE must be differentiated from Graft-Versus-Host Disease (GVHD).
Differentiating palmar plantar erythrodysesthesia from other Diseases
| Disease | Clinical manifestation | Histopathology | Additional diagnostic clues |
|---|---|---|---|
| Palmar plantar erythrodysesthesia | The areas of well-defined intense erythema and edema |
|
History of chemotherapeutic agent use |
| x1 | x2 | x3 | x4 |
| x1 | x2 | x3 | x4 |
| x1 | x2 | x3 | x4 |
| x1 | x2 | x3 | x4 |
| x1 | x2 | x3 | x4 |