Paget's disease of the breast risk factors: Difference between revisions
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{{CMG}};{{AE}} {{PSK}} | {{CMG}};{{AE}} {{PSK}} | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of Paget's disease of the breast are age | Common risk factors in the development of Paget's disease of the breast are [[female]] more than [[male]], [[incidence]] is higher with increase in [[age]] and people of [[African]] or Ashkenazi Jewish descent. Personal or family history of [[breast cancer]] Environmental exposure to [[radiation]], high temperature and electromagnetic fields. [[Mutation|Genetic mutations]] like [[BRCA1]], [[BRCA2]] 4-14% of [[male]] [[breast cancer]], [[klinefelter's syndrome]] in [[Male|males]]. [[Mutations]] in [[RAD51B]], [[PALB2]], [[CYP17]], [[CHEK2]], [[BRIP1]], [[RAD51C]] and androgen receptors. [[BRIP1]] and [[RAD51C]] have not been seen in [[male]] patients. [[Endocrine]]-related states with [[hyperestrogenism]] such as [[obesity]], exogenous [[estrogen]], [[testicular dystrophic]] [[lesions]] in males. | ||
==Risk Factors== | ==Risk Factors== | ||
Common risk factors in the development of Paget's disease of the breast are.<ref name="MorandiPession2003">{{cite journal|last1=Morandi|first1=Luca|last2=Pession|first2=Annalisa|last3=Marucci|first3=Gian Luca|last4=Foschini|first4=Maria Pia|last5=Pruneri|first5=Giancarlo|last6=Viale|first6=Giuseppe|last7=Eusebi|first7=Vincenzo|title=Intraepidermal cells of paget’s carcinoma of the breast can be genetically different from those of the underlying carcinoma|journal=Human Pathology|volume=34|issue=12|year=2003|pages=1321–1330|issn=00468177|doi=10.1016/S0046-8177(03)00405-2}}</ref><ref name="RuddyWiner2013">{{cite journal|last1=Ruddy|first1=K. J.|last2=Winer|first2=E. P.|title=Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship|journal=Annals of Oncology|volume=24|issue=6|year=2013|pages=1434–1443|issn=0923-7534|doi=10.1093/annonc/mdt025}}</ref><ref name="pmid23425944">{{cite journal |vauthors=Ruddy KJ, Winer EP |title=Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship |journal=Ann. Oncol. |volume=24 |issue=6 |pages=1434–43 |date=June 2013 |pmid=23425944 |doi=10.1093/annonc/mdt025 |url=}}</ref><ref name="OrrLemnrau2012">{{cite journal|last1=Orr|first1=Nick|last2=Lemnrau|first2=Alina|last3=Cooke|first3=Rosie|last4=Fletcher|first4=Olivia|last5=Tomczyk|first5=Katarzyna|last6=Jones|first6=Michael|last7=Johnson|first7=Nichola|last8=Lord|first8=Christopher J|last9=Mitsopoulos|first9=Costas|last10=Zvelebil|first10=Marketa|last11=McDade|first11=Simon S|last12=Buck|first12=Gemma|last13=Blancher|first13=Christine|last14=Trainer|first14=Alison H|last15=James|first15=Paul A|last16=Bojesen|first16=Stig E|last17=Bokmand|first17=Susanne|last18=Nevanlinna|first18=Heli|last19=Mattson|first19=Johanna|last20=Friedman|first20=Eitan|last21=Laitman|first21=Yael|last22=Palli|first22=Domenico|last23=Masala|first23=Giovanna|last24=Zanna|first24=Ines|last25=Ottini|first25=Laura|last26=Giannini|first26=Giuseppe|last27=Hollestelle|first27=Antoinette|last28=Ouweland|first28=Ans M W van den|last29=Novaković|first29=Srdjan|last30=Krajc|first30=Mateja|last31=Gago-Dominguez|first31=Manuela|last32=Castelao|first32=Jose Esteban|last33=Olsson|first33=Håkan|last34=Hedenfalk|first34=Ingrid|last35=Easton|first35=Douglas F|last36=Pharoah|first36=Paul D P|last37=Dunning|first37=Alison M|last38=Bishop|first38=D Timothy|last39=Neuhausen|first39=Susan L|last40=Steele|first40=Linda|last41=Houlston|first41=Richard S|last42=Garcia-Closas|first42=Montserrat|last43=Ashworth|first43=Alan|last44=Swerdlow|first44=Anthony J|title=Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk|journal=Nature Genetics|volume=44|issue=11|year=2012|pages=1182–1184|issn=1061-4036|doi=10.1038/ng.2417}}</ref> | Common risk factors in the development of Paget's disease of the breast are.<ref name="MorandiPession2003">{{cite journal|last1=Morandi|first1=Luca|last2=Pession|first2=Annalisa|last3=Marucci|first3=Gian Luca|last4=Foschini|first4=Maria Pia|last5=Pruneri|first5=Giancarlo|last6=Viale|first6=Giuseppe|last7=Eusebi|first7=Vincenzo|title=Intraepidermal cells of paget’s carcinoma of the breast can be genetically different from those of the underlying carcinoma|journal=Human Pathology|volume=34|issue=12|year=2003|pages=1321–1330|issn=00468177|doi=10.1016/S0046-8177(03)00405-2}}</ref><ref name="RuddyWiner2013">{{cite journal|last1=Ruddy|first1=K. J.|last2=Winer|first2=E. P.|title=Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship|journal=Annals of Oncology|volume=24|issue=6|year=2013|pages=1434–1443|issn=0923-7534|doi=10.1093/annonc/mdt025}}</ref><ref name="pmid23425944">{{cite journal |vauthors=Ruddy KJ, Winer EP |title=Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship |journal=Ann. Oncol. |volume=24 |issue=6 |pages=1434–43 |date=June 2013 |pmid=23425944 |doi=10.1093/annonc/mdt025 |url=}}</ref><ref name="OrrLemnrau2012">{{cite journal|last1=Orr|first1=Nick|last2=Lemnrau|first2=Alina|last3=Cooke|first3=Rosie|last4=Fletcher|first4=Olivia|last5=Tomczyk|first5=Katarzyna|last6=Jones|first6=Michael|last7=Johnson|first7=Nichola|last8=Lord|first8=Christopher J|last9=Mitsopoulos|first9=Costas|last10=Zvelebil|first10=Marketa|last11=McDade|first11=Simon S|last12=Buck|first12=Gemma|last13=Blancher|first13=Christine|last14=Trainer|first14=Alison H|last15=James|first15=Paul A|last16=Bojesen|first16=Stig E|last17=Bokmand|first17=Susanne|last18=Nevanlinna|first18=Heli|last19=Mattson|first19=Johanna|last20=Friedman|first20=Eitan|last21=Laitman|first21=Yael|last22=Palli|first22=Domenico|last23=Masala|first23=Giovanna|last24=Zanna|first24=Ines|last25=Ottini|first25=Laura|last26=Giannini|first26=Giuseppe|last27=Hollestelle|first27=Antoinette|last28=Ouweland|first28=Ans M W van den|last29=Novaković|first29=Srdjan|last30=Krajc|first30=Mateja|last31=Gago-Dominguez|first31=Manuela|last32=Castelao|first32=Jose Esteban|last33=Olsson|first33=Håkan|last34=Hedenfalk|first34=Ingrid|last35=Easton|first35=Douglas F|last36=Pharoah|first36=Paul D P|last37=Dunning|first37=Alison M|last38=Bishop|first38=D Timothy|last39=Neuhausen|first39=Susan L|last40=Steele|first40=Linda|last41=Houlston|first41=Richard S|last42=Garcia-Closas|first42=Montserrat|last43=Ashworth|first43=Alan|last44=Swerdlow|first44=Anthony J|title=Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk|journal=Nature Genetics|volume=44|issue=11|year=2012|pages=1182–1184|issn=1061-4036|doi=10.1038/ng.2417}}</ref> | ||
: | : | ||
*Gender female > male. | *Gender [[female]] > [[male]]. | ||
*Age incidence is higher with increase in age | *Age [[incidence]] is higher with increase in [[age]] | ||
*Personal history of [[breast cancer]] | *Personal history of [[breast cancer]] | ||
*Family history of breast cancer | *Family history of [[breast cancer]] | ||
*[[Irradiation]] | *[[Irradiation]] | ||
*[[Mutation|Genetic mutations]] | *[[Mutation|Genetic mutations]] | ||
**[[BRCA1]] | **[[BRCA1]] | ||
**[[BRCA2]] 4-14% of male breast cancer | **[[BRCA2]] 4-14% of [[male]] [[breast cancer]] | ||
**[[Klinefelter's syndrome]] in males. | **[[Klinefelter's syndrome]] in [[Male|males]]. | ||
** Mutations in RAD51B, PALB2, CYP17, CHEK2, BRIP1, RAD51C and androgen receptors. | ** [[Mutations]] in [[RAD51B]], [[PALB2]], [[CYP17]], [[CHEK2]], [[BRIP1]], [[RAD51C]] and androgen receptors. | ||
**BRIP1 and RAD51C have not been seen in male patients. | **[[BRIP1]] and [[RAD51C]] have not been seen in [[male]] patients. | ||
*[[Endocrine]]-related states with [[hyperestrogenism]] such as: | *[[Endocrine]]-related states with [[hyperestrogenism]] such as: | ||
:*[[obesity]] | :*[[obesity]] | ||
| Line 24: | Line 24: | ||
:*[[testicular dystrophic]] [[lesions]] in males. | :*[[testicular dystrophic]] [[lesions]] in males. | ||
*Environmental exposure to radiation, high temperature and electromagnetic fields. | *Environmental exposure to radiation, high temperature and electromagnetic fields. | ||
*[[Orchitis/epididymitis]] in males. | *[[Epididymoorchitis|Orchitis/epididymitis]] in males. | ||
*Volatile organic compounds (like: tetrachloroethylene, perchloroethylene, trichloroethylene, dichloroethylene, and benzene) | *Volatile organic compounds (like: [[tetrachloroethylene]], [[perchloroethylene]], [[trichloroethylene]], [[dichloroethylene]], and [[benzene]]) | ||
* | *Socio-demographic factors such as: | ||
:*People of African or Ashkenazi Jewish descent | :*People of [[African]] or Ashkenazi Jewish descent | ||
:*Excessive use of alcohol | :*Excessive use of [[alcohol]] | ||
==References== | ==References== | ||
Revision as of 16:27, 14 March 2019
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Paget's disease of the breast Microchapters |
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Differentiating Paget's disease of the breast from other Diseases |
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Paget's disease of the breast risk factors On the Web |
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Directions to Hospitals Treating Paget's disease of the breast |
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Risk calculators and risk factors for Paget's disease of the breast risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Common risk factors in the development of Paget's disease of the breast are female more than male, incidence is higher with increase in age and people of African or Ashkenazi Jewish descent. Personal or family history of breast cancer Environmental exposure to radiation, high temperature and electromagnetic fields. Genetic mutations like BRCA1, BRCA2 4-14% of male breast cancer, klinefelter's syndrome in males. Mutations in RAD51B, PALB2, CYP17, CHEK2, BRIP1, RAD51C and androgen receptors. BRIP1 and RAD51C have not been seen in male patients. Endocrine-related states with hyperestrogenism such as obesity, exogenous estrogen, testicular dystrophic lesions in males.
Risk Factors
Common risk factors in the development of Paget's disease of the breast are.[1][2][3][4]
- Gender female > male.
- Age incidence is higher with increase in age
- Personal history of breast cancer
- Family history of breast cancer
- Irradiation
- Genetic mutations
- Endocrine-related states with hyperestrogenism such as:
- obesity
- exogenous estrogen
- testicular dystrophic lesions in males.
- Environmental exposure to radiation, high temperature and electromagnetic fields.
- Orchitis/epididymitis in males.
- Volatile organic compounds (like: tetrachloroethylene, perchloroethylene, trichloroethylene, dichloroethylene, and benzene)
- Socio-demographic factors such as:
References
- ↑ Morandi, Luca; Pession, Annalisa; Marucci, Gian Luca; Foschini, Maria Pia; Pruneri, Giancarlo; Viale, Giuseppe; Eusebi, Vincenzo (2003). "Intraepidermal cells of paget's carcinoma of the breast can be genetically different from those of the underlying carcinoma". Human Pathology. 34 (12): 1321–1330. doi:10.1016/S0046-8177(03)00405-2. ISSN 0046-8177.
- ↑ Ruddy, K. J.; Winer, E. P. (2013). "Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship". Annals of Oncology. 24 (6): 1434–1443. doi:10.1093/annonc/mdt025. ISSN 0923-7534.
- ↑ Ruddy KJ, Winer EP (June 2013). "Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship". Ann. Oncol. 24 (6): 1434–43. doi:10.1093/annonc/mdt025. PMID 23425944.
- ↑ Orr, Nick; Lemnrau, Alina; Cooke, Rosie; Fletcher, Olivia; Tomczyk, Katarzyna; Jones, Michael; Johnson, Nichola; Lord, Christopher J; Mitsopoulos, Costas; Zvelebil, Marketa; McDade, Simon S; Buck, Gemma; Blancher, Christine; Trainer, Alison H; James, Paul A; Bojesen, Stig E; Bokmand, Susanne; Nevanlinna, Heli; Mattson, Johanna; Friedman, Eitan; Laitman, Yael; Palli, Domenico; Masala, Giovanna; Zanna, Ines; Ottini, Laura; Giannini, Giuseppe; Hollestelle, Antoinette; Ouweland, Ans M W van den; Novaković, Srdjan; Krajc, Mateja; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Olsson, Håkan; Hedenfalk, Ingrid; Easton, Douglas F; Pharoah, Paul D P; Dunning, Alison M; Bishop, D Timothy; Neuhausen, Susan L; Steele, Linda; Houlston, Richard S; Garcia-Closas, Montserrat; Ashworth, Alan; Swerdlow, Anthony J (2012). "Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk". Nature Genetics. 44 (11): 1182–1184. doi:10.1038/ng.2417. ISSN 1061-4036.