Paget's disease of the breast other diagnostic studies

Revision as of 18:09, 14 March 2019 by Preeti Singh (talk | contribs)
Jump to navigation Jump to search

Paget's disease of the breast Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Paget's disease of the breast from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Biopsy

Ultrasonography

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Paget's disease of the breast other diagnostic studies On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Paget's disease of the breast other diagnostic studies

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Paget's disease of the breast other diagnostic studies

CDC on Paget's disease of the breast other diagnostic studies

Paget's disease of the breast other diagnostic studies in the news

Blogs on Paget's disease of the breast other diagnostic studies

Directions to Hospitals Treating Paget's disease of the breast

Risk calculators and risk factors for Paget's disease of the breast other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]

Overview

The use of touch/scrape smears for cytological diagnosis is recommended to prevent delay in diagnosis. Mainly in patients who are reluctant to undergo other diagnostic procedures such as wedge biopsy, shave biopsy, surgical excision. A negative result does not exclude the diagnosis of Paget's disease of the breast.

Other Diasgnostic Findings

Cytology

  • The use of touch/scrape smears for cytological diagnosis is recommended to prevent delay in diagnosis.
  • Mainly in patients who are reluctant to undergo other diagnostic procedures such as wedge biopsy, shave biopsy, surgical excision.
  • Due to the difficulty in differentiating Paget's disease from inflammatory skin conditions or squamous neoplasia on cytology, a biopsy of the nipple and areola is generally preferred for definitive diagnosis.
  • Cytology of skin scrapings many time display the presence of:
  • Single malignant cells with vacuolated cytoplasm and eccentric nuclei
  • Three dimensional cell aggregates
  • Acinar groups consistent with glandular differentiation
  • A negative result does not exclude the diagnosis of Paget's disease of the breast.[1][2]

In vivo reflectance confocal microscopy

In vivo reflectance confocal microscopy allows visualization of the upper layers of the skin at a cellular resolution, may also assist in the early diagnosis of Paget's disease in reluctant patients.


References

  1. Lucarotti ME, Dunn JM, Webb AJ (October 1994). "Scrape cytology in the diagnosis of Paget's disease of the breast". Cytopathology. 5 (5): 301–5. PMID 7529588.
  2. Samarasinghe D, Frost F, Sterrett G, Whitaker D, Ingram D, Sheiner H (1993). "Cytological diagnosis of Paget's disease of the nipple by scrape smears: a report of five cases". Diagn. Cytopathol. 9 (3): 291–5. PMID 8390930.

Template:WH Template:WS