Paget's disease of the breast natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Prognosis
- The prognosis for people with Paget's disease of the breast depends on a variety of factors, and is primarily determined by the underlying tumor.
- Some factors indicate an unfavorable prognosis, such as:[1][2]
- Presence of palpable breast tumor
- Enlarged lymph nodes
- Histological type of breast cancer
- Patients younger than 60 years
- Prognosis of Paget's disease is worse in males than in females.
Survival rates
- In patients with Paget's disease of the breast mean survival was found to be 80.0 months for males and 108.2 months for females.
- Five-year survival rate has been reported to be 20-30% in males, compared to 30-40% in females.It has been hypothesized due to the small size of mammary gland in males.[3][4]
- The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival.
- Lymph node involvement is correlated with median survival rates, reaching 75-95% when negative and 20 to 25% when positive.
- In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes.
- When the disease occurs in males, the prognosis is poor, with an average 5-year survival rate of 20-30%.
- Patients with Paget disease concomitant infiltrating duct carcinoma (PD‐IDC)had the worst prognosis with 5‐year survival rate = 84.1%.
- The Paget disease concomitant intraductal carcinoma (PD‐DCIS) had the best prognosis with 5‐year survival rate = 97.5%.
- Among patients with Paget disease those who are married have a better prognosis than who were not.
- Marital status is said to be associated with the hormone receptor status in patients with PD‐IDC.[5]
References
- ↑ Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.
- ↑ Paget's disease of the breast. National cancer institute. http://www.cancer.gov/types/breast/paget-breast-fact-sheet
- ↑ . doi:10.1001/ archdermatol.2008.508. Check
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(help) - ↑ Leibou L, Herman O, Frand J, Kramer E, Mordechai S (January 2015). "Paget's disease of the male breast with underlying ductal carcinoma in situ". Isr. Med. Assoc. J. 17 (1): 64–5. PMID 25739183.
- ↑ Zhao Y, Sun HF, Chen MT, Gao SP, Li LD, Jiang HL, Jin W (June 2018). "Clinicopathological characteristics and survival outcomes in Paget disease: a SEER population-based study". Cancer Med. 7 (6): 2307–2318. doi:10.1002/cam4.1475. PMC 6010794. PMID 29722170.