Paget's disease of the breast natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for people with Paget's disease of the breast depends on a variety of factors. Some factors indicate an unfavorable prognosis, among them:<ref name="Lopes FilhoLopes2015">{{cite journal|last1=Lopes Filho|first1=Lauro Lourival|last2=Lopes|first2=Ione Maria Ribeiro Soares|last3=Lopes|first3=Lauro Rodolpho Soares|last4=Enokihara|first4=Milvia M. S. S.|last5=Michalany|first5=Alexandre Osores|last6=Matsunaga|first6=Nobuo|title=Mammary and extramammary Paget's disease|journal=Anais Brasileiros de Dermatologia|volume=90|issue=2|year=2015|pages=225–231|issn=1806-4841|doi=10.1590/abd1806-4841.20153189}}</ref> | The prognosis for people with Paget's disease of the breast depends on a variety of factors. Some factors indicate an unfavorable [[prognosis]], among them:<ref name="Lopes FilhoLopes2015">{{cite journal|last1=Lopes Filho|first1=Lauro Lourival|last2=Lopes|first2=Ione Maria Ribeiro Soares|last3=Lopes|first3=Lauro Rodolpho Soares|last4=Enokihara|first4=Milvia M. S. S.|last5=Michalany|first5=Alexandre Osores|last6=Matsunaga|first6=Nobuo|title=Mammary and extramammary Paget's disease|journal=Anais Brasileiros de Dermatologia|volume=90|issue=2|year=2015|pages=225–231|issn=1806-4841|doi=10.1590/abd1806-4841.20153189}}</ref> | ||
<ref name=NIH>Paget's disease of the breast. National cancer institute. http://www.cancer.gov/types/breast/paget-breast-fact-sheet</ref> | <ref name=NIH>Paget's disease of the breast. National cancer institute. http://www.cancer.gov/types/breast/paget-breast-fact-sheet</ref> | ||
*Presence of palpable breast tumor | *Presence of palpable breast tumor | ||
*Enlarged lymph nodes | *Enlarged [[lymph nodes]] | ||
*Histological type of breast cancer | *Histological type of breast cancer | ||
*Patients younger than 60 years | *Patients younger than 60 years |
Revision as of 20:32, 18 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Prognosis
The prognosis for people with Paget's disease of the breast depends on a variety of factors. Some factors indicate an unfavorable prognosis, among them:[1] [2]
- Presence of palpable breast tumor
- Enlarged lymph nodes
- Histological type of breast cancer
- Patients younger than 60 years
Survival rates
- The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival.
- Lymph node involvement is correlated with median survival rates, reaching 75-95% when negative and 20 to 25% when positive.
- In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes.
- When the disease occurs in males, the prognosis is poor, with an average 5-year survival rate of 20-30%.
References
- ↑ Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.
- ↑ Paget's disease of the breast. National cancer institute. http://www.cancer.gov/types/breast/paget-breast-fact-sheet