Paget's disease of the breast natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Prognosis== | ==Prognosis== | ||
The prognosis for people with Paget's disease of the breast depends on a variety of factors. Some factors indicate an unfavorable prognosis, among them:<ref name="Lopes FilhoLopes2015">{{cite journal|last1=Lopes Filho|first1=Lauro Lourival|last2=Lopes|first2=Ione Maria Ribeiro Soares|last3=Lopes|first3=Lauro Rodolpho Soares|last4=Enokihara|first4=Milvia M. S. S.|last5=Michalany|first5=Alexandre Osores|last6=Matsunaga|first6=Nobuo|title=Mammary and extramammary Paget's disease|journal=Anais Brasileiros de Dermatologia|volume=90|issue=2|year=2015|pages=225–231|issn=1806-4841|doi=10.1590/abd1806-4841.20153189}}</ref> | *The prognosis for people with Paget's disease of the breast depends on a variety of factors. Some factors indicate an unfavorable prognosis, among them:<ref name="Lopes FilhoLopes2015">{{cite journal|last1=Lopes Filho|first1=Lauro Lourival|last2=Lopes|first2=Ione Maria Ribeiro Soares|last3=Lopes|first3=Lauro Rodolpho Soares|last4=Enokihara|first4=Milvia M. S. S.|last5=Michalany|first5=Alexandre Osores|last6=Matsunaga|first6=Nobuo|title=Mammary and extramammary Paget's disease|journal=Anais Brasileiros de Dermatologia|volume=90|issue=2|year=2015|pages=225–231|issn=1806-4841|doi=10.1590/abd1806-4841.20153189}}</ref> | ||
<ref name=NIH>Paget's disease of the breast. National cancer institute. http://www.cancer.gov/types/breast/paget-breast-fact-sheet</ref> | <ref name=NIH>Paget's disease of the breast. National cancer institute. http://www.cancer.gov/types/breast/paget-breast-fact-sheet</ref> | ||
*Presence of palpable breast tumor | **Presence of palpable breast tumor | ||
*Enlarged lymph nodes | **Enlarged lymph nodes | ||
*Histological type of breast cancer | **Histological type of breast cancer | ||
*Patients younger than 60 years | **Patients younger than 60 years | ||
*The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival. | |||
The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival. | *Lymph node involvement is correlated with median survival rates, reaching 75-95% when negative and 20 to 25% when positive. | ||
According to NCI’s Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget's disease of the breast between 1988 and 2001 was 82.6 percent. This compares with a 5-year relative survival of 87.1 percent for women diagnosed with any type of breast cancer. For women with both Paget's disease of the breast and invasive cancer in the same breast, the 5-year relative survival declined with increasing stage of the cancer (stage I, 95.8 percent; stage II, 77.7 percent; stage III, 46.3 percent; stage IV, 14.3 percent). | According to NCI’s Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget's disease of the breast between 1988 and 2001 was 82.6 percent. This compares with a 5-year relative survival of 87.1 percent for women diagnosed with any type of breast cancer. For women with both Paget's disease of the breast and invasive cancer in the same breast, the 5-year relative survival declined with increasing stage of the cancer (stage I, 95.8 percent; stage II, 77.7 percent; stage III, 46.3 percent; stage IV, 14.3 percent). | ||
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**Histological type of breast cancer | **Histological type of breast cancer | ||
**Patients younger than 60 years | **Patients younger than 60 years | ||
*In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes. | *In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes. | ||
*When the disease occurs in males, the prognosis is poor, with an average 5-year survival rate of 20-30%. | *When the disease occurs in males, the prognosis is poor, with an average 5-year survival rate of 20-30%. | ||
Revision as of 15:01, 13 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Prognosis
- The prognosis for people with Paget's disease of the breast depends on a variety of factors. Some factors indicate an unfavorable prognosis, among them:[1]
- Presence of palpable breast tumor
- Enlarged lymph nodes
- Histological type of breast cancer
- Patients younger than 60 years
- The presence of invasive cancer in the affected breast and the spread of cancer to nearby lymph nodes are associated with reduced survival.
- Lymph node involvement is correlated with median survival rates, reaching 75-95% when negative and 20 to 25% when positive.
According to NCI’s Surveillance, Epidemiology, and End Results program, the 5-year relative survival for all women in the United States who were diagnosed with Paget's disease of the breast between 1988 and 2001 was 82.6 percent. This compares with a 5-year relative survival of 87.1 percent for women diagnosed with any type of breast cancer. For women with both Paget's disease of the breast and invasive cancer in the same breast, the 5-year relative survival declined with increasing stage of the cancer (stage I, 95.8 percent; stage II, 77.7 percent; stage III, 46.3 percent; stage IV, 14.3 percent).
When there is a palpable breast mass, almost always the carcinoma is invasive and associated with high rates of axillary lymph node metastases. Lymph node involvement is correlated with median survival rates, reaching 75-95% when negative and 20 to 25% when positive. In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes. When the disease occurs in males, the prognosis is poor, with an average 5-year survival rate of 20-30%.
Prognosis
- Some factors indicate an unfavorable prognosis, among them:[1]
- The presence of a palpable breast tumor
- Enlarged lymph nodes
- Histological type of breast cancer
- Patients younger than 60 years
- In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes.
- When the disease occurs in males, the prognosis is poor, with an average 5-year survival rate of 20-30%.
References
- ↑ 1.0 1.1 Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.
- ↑ Paget's disease of the breast. National cancer institute. http://www.cancer.gov/types/breast/paget-breast-fact-sheet