PPP1R2: Difference between revisions

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{{Infobox_gene}}
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'''Protein phosphatase inhibitor 2''' is an [[enzyme]] that in humans is encoded by the ''PPP1R2'' [[gene]].<ref name="pmid9126490">{{cite journal |vauthors=Permana PA, Mott DM | title = Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians | journal = Genomics | volume = 41 | issue = 1 | pages = 110–4 |date=May 1997 | pmid = 9126490 | pmc =  | doi = 10.1006/geno.1997.4649 }}</ref><ref name="pmid8119416">{{cite journal |vauthors=Helps NR, Street AJ, Elledge SJ, Cohen PT | title = Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli | journal = FEBS Lett | volume = 340 | issue = 1-2 | pages = 93–8 |date=Apr 1994 | pmid = 8119416 | pmc =  | doi =10.1016/0014-5793(94)80179-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5504| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein phosphatase 1, regulatory (inhibitor) subunit 2
| HGNCid = 9288
| Symbol = PPP1R2
| AltSymbols =; IPP2; MGC87148
| OMIM = 601792
| ECnumber =
| Homologene = 4546
| MGIid = 1914099
  | GeneAtlas_image1 = PBB_GE_PPP1R2_202165_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPP1R2_202166_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004864 |text = protein phosphatase inhibitor activity}} {{GNF_GO|id=GO:0004865 |text = type 1 serine/threonine specific protein phosphatase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0005977 |text = glycogen metabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0009966 |text = regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5504
    | Hs_Ensembl = ENSG00000184203
    | Hs_RefseqProtein = NP_006232
    | Hs_RefseqmRNA = NM_006241
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 196722514
    | Hs_GenLoc_end = 196751362
    | Hs_Uniprot = P41236
    | Mm_EntrezGene = 66849
    | Mm_Ensembl = ENSMUSG00000047714
    | Mm_RefseqmRNA = NM_025800
    | Mm_RefseqProtein = NP_080076
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 31171284
    | Mm_GenLoc_end = 31195024
    | Mm_Uniprot = Q9CT86
  }}
}}
'''Protein phosphatase 1, regulatory (inhibitor) subunit 2''', also known as '''PPP1R2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5504| accessdate = }}</ref>
 
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==Interactions==
PPP1R2 has been shown to [[Protein-protein interaction|interact]] with [[LMTK2]]<ref name=pmid12393858>{{cite journal |last=Wang |first=Hong |authorlink= |author2=Brautigan David L |date=Dec 2002 |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2 |journal=J. Biol. Chem. |volume=277 |issue=51 |pages=49605–12 |publisher= |location = United States| issn = 0021-9258| pmid = 12393858 |doi = 10.1074/jbc.M209335200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[PPP1R9B]].<ref name=pmid12270929>{{cite journal |last=Terry-Lorenzo |first=Ryan T |authorlink= |author2=Elliot Elizabeth |author3=Weiser Douglas C |author4=Prickett Todd D |author5=Brautigan David L |author6=Shenolikar Shirish  |date=Nov 2002 |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton |journal=J. Biol. Chem. |volume=277 |issue=48 |pages=46535–43 |publisher= |location = United States| issn = 0021-9258| pmid = 12270929 |doi = 10.1074/jbc.M206960200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Sanséau P, Jackson A, Alderton RP, ''et al.'' |title=Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. |journal=Mamm. Genome |volume=5 |issue= 8 |pages= 490-6 |year= 1994 |pmid= 7949733 |doi=  }}
*{{cite journal   |vauthors=Sanséau P, Jackson A, Alderton RP, etal |title=Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences. |journal=Mamm. Genome |volume=5 |issue= 8 |pages= 490–6 |year= 1994 |pmid= 7949733 |doi=10.1007/BF00369318 }}
*{{cite journal | author=Helps NR, Street AJ, Elledge SJ, Cohen PT |title=Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. |journal=FEBS Lett. |volume=340 |issue= 1-2 |pages= 93-8 |year= 1994 |pmid= 8119416 |doi=  }}
*{{cite journal   |vauthors=Park IK, Roach P, Bondor J, etal |title=Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 944–54 |year= 1994 |pmid= 8288648 |doi=  }}
*{{cite journal  | author=Park IK, Roach P, Bondor J, ''et al.'' |title=Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2. |journal=J. Biol. Chem. |volume=269 |issue= 2 |pages= 944-54 |year= 1994 |pmid= 8288648 |doi=  }}
*{{cite journal  |vauthors=Kakinoki Y, Somers J, Brautigan DL |title=Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32308–14 |year= 1998 |pmid= 9405437 |doi=10.1074/jbc.272.51.32308 }}
*{{cite journal  | author=Permana PA, Mott DM |title=Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. |journal=Genomics |volume=41 |issue= 1 |pages= 110-4 |year= 1997 |pmid= 9126490 |doi= 10.1006/geno.1997.4649 }}
*{{cite journal  |vauthors=Yang J, Hurley TD, DePaoli-Roach AA |title=Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22635–44 |year= 2000 |pmid= 10807923 |doi= 10.1074/jbc.M003082200 }}
*{{cite journal  | author=Kakinoki Y, Somers J, Brautigan DL |title=Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32308-14 |year= 1998 |pmid= 9405437 |doi= }}
*{{cite journal  |vauthors=Agarwal-Mawal A, Paudel HK |title=Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23712–8 |year= 2001 |pmid= 11320080 |doi= 10.1074/jbc.M010002200 }}
*{{cite journal  | author=Yang J, Hurley TD, DePaoli-Roach AA |title=Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22635-44 |year= 2000 |pmid= 10807923 |doi= 10.1074/jbc.M003082200 }}
*{{cite journal  |vauthors=Eto M, Elliott E, Prickett TD, Brautigan DL |title=Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44013–20 |year= 2003 |pmid= 12221103 |doi= 10.1074/jbc.M208035200 }}
*{{cite journal | author=Agarwal-Mawal A, Paudel HK |title=Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23712-8 |year= 2001 |pmid= 11320080 |doi= 10.1074/jbc.M010002200 }}
*{{cite journal   |vauthors=Terry-Lorenzo RT, Elliot E, Weiser DC, etal |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46535–43 |year= 2003 |pmid= 12270929 |doi= 10.1074/jbc.M206960200 }}
*{{cite journal  | author=Eto M, Elliott E, Prickett TD, Brautigan DL |title=Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44013-20 |year= 2003 |pmid= 12221103 |doi= 10.1074/jbc.M208035200 }}
*{{cite journal  |vauthors=Wang H, Brautigan DL |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49605–12 |year= 2003 |pmid= 12393858 |doi= 10.1074/jbc.M209335200 }}
*{{cite journal | author=Terry-Lorenzo RT, Elliot E, Weiser DC, ''et al.'' |title=Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46535-43 |year= 2003 |pmid= 12270929 |doi= 10.1074/jbc.M206960200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Wang H, Brautigan DL |title=A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49605-12 |year= 2003 |pmid= 12393858 |doi= 10.1074/jbc.M209335200 }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Leach C, Shenolikar S, Brautigan DL |title=Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 26015–20 |year= 2003 |pmid= 12697755 |doi= 10.1074/jbc.M300782200 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal   |vauthors=Sakashita G, Shima H, Komatsu M, etal |title=Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 165–71 |year= 2004 |pmid= 12761178 |doi=10.1093/jb/mvg020  }}
*{{cite journal | author=Leach C, Shenolikar S, Brautigan DL |title=Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 26015-20 |year= 2003 |pmid= 12697755 |doi= 10.1074/jbc.M300782200 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
*{{cite journal | author=Sakashita G, Shima H, Komatsu M, ''et al.'' |title=Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells. |journal=J. Biochem. |volume=133 |issue= 2 |pages= 165-71 |year= 2004 |pmid= 12761178 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Yamada M, Ikeda Y, Yano M, etal |title=Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy. |journal=FASEB J. |volume=20 |issue= 8 |pages= 1197–9 |year= 2006 |pmid= 16627625 |doi= 10.1096/fj.05-5299fje }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=King TD, Gandy JC, Bijur GN |title=The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels. |journal=Exp. Cell Res. |volume=312 |issue= 18 |pages= 3693–700 |year= 2007 |pmid= 16987514 |doi= 10.1016/j.yexcr.2006.08.010  | pmc=1885546 }}
*{{cite journal  | author=Yamada M, Ikeda Y, Yano M, ''et al.'' |title=Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy. |journal=FASEB J. |volume=20 |issue= 8 |pages= 1197-9 |year= 2006 |pmid= 16627625 |doi= 10.1096/fj.05-5299fje }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=King TD, Gandy JC, Bijur GN |title=The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels. |journal=Exp. Cell Res. |volume=312 |issue= 18 |pages= 3693-700 |year= 2007 |pmid= 16987514 |doi= 10.1016/j.yexcr.2006.08.010 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:34, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene.[1][2][3]


Interactions

PPP1R2 has been shown to interact with LMTK2[4] and PPP1R9B.[5]

References

  1. ↑ Permana PA, Mott DM (May 1997). "Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians". Genomics. 41 (1): 110–4. doi:10.1006/geno.1997.4649. PMID 9126490.
  2. ↑ Helps NR, Street AJ, Elledge SJ, Cohen PT (Apr 1994). "Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli". FEBS Lett. 340 (1–2): 93–8. doi:10.1016/0014-5793(94)80179-7. PMID 8119416.
  3. ↑ "Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2".
  4. ↑ Wang, Hong; Brautigan David L (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. United States. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. ISSN 0021-9258. PMID 12393858.
  5. ↑ Terry-Lorenzo, Ryan T; Elliot Elizabeth; Weiser Douglas C; Prickett Todd D; Brautigan David L; Shenolikar Shirish (Nov 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. United States. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929.

Further reading



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