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{{ | '''Phosphatidylinositol 3-kinase regulatory subunit gamma''' is an [[enzyme]], which in humans is encoded by the ''PIK3R3'' [[gene]].<ref name="pmid9524259">{{cite journal |vauthors=Dey BR, Furlanetto RW, Nissley SP | title = Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor | journal = Gene | volume = 209 | issue = 1–2 | pages = 175–83 |date=May 1998 | pmid = 9524259 | pmc = | doi =10.1016/S0378-1119(98)00045-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8503| accessdate = }}</ref> | ||
}} | |||
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==Interactions== | |||
PIK3R3 has been shown to [[Protein-protein interaction|interact]] with [[Insulin-like growth factor 1 receptor]],<ref name=pmid9415396>{{cite journal |doi=10.1210/mend.11.13.0029 |last=Mothe |first=I |authorlink= |author2=Delahaye L |author3=Filloux C |author4=Pons S |author5=White M F |author6=Van Obberghen E |date=Dec 1997 |title=Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins |journal=Mol. Endocrinol. |volume=11 |issue=13 |pages=1911–23 |publisher= |location = UNITED STATES| issn = 0888-8809| pmid = 9415396 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[IRS1]]<ref name=pmid9415396/><ref name=pmid10417350>{{cite journal |last=Xia |first=X |authorlink= |author2=Serrero G |date=Aug 1999 |title=Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation |journal=Biochem. J. |volume=341 |issue= 3|pages=831–7 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 10417350 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1220424 | doi=10.1042/0264-6021:3410831}}</ref> and [[Retinoblastoma protein]].<ref name=pmid12588990>{{cite journal |doi=10.1128/MCB.23.5.1717-1725.2003 |last=Xia |first=Xianmin |authorlink= |author2=Cheng Aiwu |author3=Akinmade Damilola |author4=Hamburger Anne W |date=Mar 2003 |title=The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest |journal=Mol. Cell. Biol. |volume=23 |issue=5 |pages=1717–25 |publisher= |location = United States| issn = 0270-7306| pmid = 12588990 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=151709 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Pons S, Asano T, Glasheen E, etal |title=The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase |journal=Mol. Cell. Biol. |volume=15 |issue= 8 |pages= 4453–65 |year= 1995 |pmid= 7542745 |doi= | pmc=230685 }} | ||
*{{cite journal | *{{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }} | ||
*{{cite journal | *{{cite journal |vauthors=Tuscano JM, Engel P, Tedder TF, etal |title=Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22 |journal=Eur. J. Immunol. |volume=26 |issue= 6 |pages= 1246–52 |year= 1996 |pmid= 8647200 |doi=10.1002/eji.1830260610 }} | ||
*{{cite journal | *{{cite journal |vauthors=Takahashi-Tezuka M, Hibi M, Fujitani Y, etal |title=Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK |journal=Oncogene |volume=14 |issue= 19 |pages= 2273–82 |year= 1997 |pmid= 9178903 |doi= 10.1038/sj.onc.1201071 }} | ||
*{{cite journal | *{{cite journal |vauthors=Mothe I, Delahaye L, Filloux C, etal |title=Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins |journal=Mol. Endocrinol. |volume=11 |issue= 13 |pages= 1911–23 |year= 1998 |pmid= 9415396 |doi=10.1210/mend.11.13.0029 }} | ||
*{{cite journal |vauthors=Xia X, Serrero G |title=Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation |journal=Biochem. J. |volume=341 |issue= 3|pages= 831–7 |year= 1999 |pmid= 10417350 |doi=10.1042/0264-6021:3410831 | pmc=1220424 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Inukai K, Funaki M, Anai M, etal |title=Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations |journal=FEBS Lett. |volume=490 |issue= 1–2 |pages= 32–8 |year= 2001 |pmid= 11172806 |doi=10.1016/S0014-5793(01)02132-9 }} | ||
*{{cite journal | *{{cite journal |vauthors=Hafizi S, Alindri F, Karlsson R, Dahlbäck B |title=Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 793–800 |year= 2003 |pmid= 12470648 |doi=10.1016/S0006-291X(02)02718-3 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Xia X, Cheng A, Akinmade D, Hamburger AW |title=The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest |journal=Mol. Cell. Biol. |volume=23 |issue= 5 |pages= 1717–25 |year= 2003 |pmid= 12588990 |doi=10.1128/MCB.23.5.1717-1725.2003 | pmc=151709 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | ||
*{{cite journal | *{{cite journal |vauthors=Soroceanu L, Kharbanda S, Chen R, etal |title=Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 9 |pages= 3466–71 |year= 2007 |pmid= 17360667 |doi= 10.1073/pnas.0611271104 | pmc=1802005 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kallin A, Johannessen LE, Cani PD, etal |title=SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma |journal=J. Lipid Res. |volume=48 |issue= 7 |pages= 1628–36 |year= 2007 |pmid= 17452746 |doi= 10.1194/jlr.M700136-JLR200 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=8503}} | |||
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Revision as of 18:09, 7 September 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
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Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.[1][2]
Interactions
PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,[3] IRS1[3][4] and Retinoblastoma protein.[5]
References
- ↑ Dey BR, Furlanetto RW, Nissley SP (May 1998). "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor". Gene. 209 (1–2): 175–83. doi:10.1016/S0378-1119(98)00045-6. PMID 9524259.
- ↑ "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)".
- ↑ 3.0 3.1 Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. UNITED STATES. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. ISSN 0888-8809. PMID 9415396.
- ↑ Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. ENGLAND. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN 0264-6021. PMC 1220424. PMID 10417350.
- ↑ Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. United States. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN 0270-7306. PMC 151709. PMID 12588990.
Further reading
- Pons S, Asano T, Glasheen E, et al. (1995). "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase". Mol. Cell. Biol. 15 (8): 4453–65. PMC 230685. PMID 7542745.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Tuscano JM, Engel P, Tedder TF, et al. (1996). "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22". Eur. J. Immunol. 26 (6): 1246–52. doi:10.1002/eji.1830260610. PMID 8647200.
- Takahashi-Tezuka M, Hibi M, Fujitani Y, et al. (1997). "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID 9178903.
- Mothe I, Delahaye L, Filloux C, et al. (1998). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. PMID 9415396.
- Xia X, Serrero G (1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. PMC 1220424. PMID 10417350.
- Inukai K, Funaki M, Anai M, et al. (2001). "Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations". FEBS Lett. 490 (1–2): 32–8. doi:10.1016/S0014-5793(01)02132-9. PMID 11172806.
- Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Xia X, Cheng A, Akinmade D, Hamburger AW (2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. PMC 151709. PMID 12588990.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Soroceanu L, Kharbanda S, Chen R, et al. (2007). "Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3466–71. doi:10.1073/pnas.0611271104. PMC 1802005. PMID 17360667.
- Kallin A, Johannessen LE, Cani PD, et al. (2007). "SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma". J. Lipid Res. 48 (7): 1628–36. doi:10.1194/jlr.M700136-JLR200. PMID 17452746.
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