PIGQ: Difference between revisions

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{{Infobox_gene}}
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'''Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q''' is an [[enzyme]] that in humans is encoded by the ''PIGQ'' [[gene]].<ref name="pmid9463366">{{cite journal | vauthors = Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T | title = The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1 | journal = EMBO J | volume = 17 | issue = 4 | pages = 877–85 |date=Mar 1998 | pmid = 9463366 | pmc = 1170437 | doi = 10.1093/emboj/17.4.877 }}</ref><ref name="pmid9729469">{{cite journal | vauthors = Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE | title = Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants | journal = Biochem J | volume = 334 | issue =  3| pages = 609–16 |date=Nov 1998 | pmid = 9729469 | pmc = 1219730 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9091| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phosphatidylinositol glycan anchor biosynthesis, class Q
| HGNCid = 14135
| Symbol = PIGQ
| AltSymbols =; GPI1; MGC12693; c407A10.1; hGPI1
| OMIM = 605754
| ECnumber =
| Homologene = 31228
| MGIid = 1333114
| GeneAtlas_image1 = PBB_GE_PIGQ_204144_s_at_tn.png
| Function = {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}} {{GNF_GO|id=GO:0017176 |text = phosphatidylinositol N-acetylglucosaminyltransferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006506 |text = GPI anchor biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9091
    | Hs_Ensembl = ENSG00000007541
    | Hs_RefseqProtein = NP_004195
    | Hs_RefseqmRNA = NM_004204
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 560005
    | Hs_GenLoc_end = 574109
    | Hs_Uniprot = Q9BRB3
    | Mm_EntrezGene = 14755
    | Mm_Ensembl = ENSMUSG00000025728
    | Mm_RefseqmRNA = XM_001005461
    | Mm_RefseqProtein = XP_001005461
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 25654024
    | Mm_GenLoc_end = 25669562
    | Mm_Uniprot = Q3TF56
  }}
}}
'''Phosphatidylinositol glycan anchor biosynthesis, class Q''', also known as '''PIGQ''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9091| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).<ref name="entrez">{{cite web | title = Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9091| accessdate = }}</ref>
| summary_text = This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).<ref name="entrez" />
}}
}}
==Interactions==
PIGQ has been shown to [[Protein-protein interaction|interact]] with [[PIGH]],<ref name=pmid9463366 /> [[PIGA]]<ref name=pmid9463366/> and [[PIGC]].<ref name=pmid9463366/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Martin J, Han C, Gordon LA, ''et al.'' |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988-94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal   |vauthors=Martin J, Han C, Gordon LA, etal |title=The sequence and analysis of duplication-rich human chromosome 16 |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Tiede A, Daniels RJ, Higgs DR, ''et al.'' |title=The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis. |journal=Gene |volume=271 |issue= 2 |pages= 247-54 |year= 2001 |pmid= 11418246 |doi=  }}
*{{cite journal   |vauthors=Tiede A, Daniels RJ, Higgs DR, etal |title=The human GPI1 gene is required for efficient glycosylphosphatidylinositol biosynthesis |journal=Gene |volume=271 |issue= 2 |pages= 247–54 |year= 2001 |pmid= 11418246 |doi=10.1016/S0378-1119(01)00510-8 }}
*{{cite journal | author=Daniels RJ, Peden JF, Lloyd C, ''et al.'' |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339-52 |year= 2001 |pmid= 11157797 |doi=  }}
*{{cite journal   |vauthors=Daniels RJ, Peden JF, Lloyd C, etal |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=10.1093/hmg/10.4.339 }}
*{{cite journal | author=Watanabe R, Murakami Y, Marmor MD, ''et al.'' |title=Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. |journal=EMBO J. |volume=19 |issue= 16 |pages= 4402-11 |year= 2000 |pmid= 10944123 |doi= 10.1093/emboj/19.16.4402 }}
*{{cite journal   |vauthors=Watanabe R, Murakami Y, Marmor MD, etal |title=Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2 |journal=EMBO J. |volume=19 |issue= 16 |pages= 4402–11 |year= 2000 |pmid= 10944123 |doi= 10.1093/emboj/19.16.4402 | pmc=302040 }}
*{{cite journal | author=Hong Y, Ohishi K, Watanabe R, ''et al.'' |title=GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18582-8 |year= 1999 |pmid= 10373468 |doi= }}
*{{cite journal   |vauthors=Hong Y, Ohishi K, Watanabe R, etal |title=GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18582–8 |year= 1999 |pmid= 10373468 |doi=10.1074/jbc.274.26.18582 }}
*{{cite journal  | author=Tiede A, Schubert J, Nischan C, ''et al.'' |title=Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants. |journal=Biochem. J. |volume=334 ( Pt 3) |issue=  |pages= 609-16 |year= 1998 |pmid= 9729469 |doi= }}
*{{cite journal   |vauthors=Watanabe R, Kinoshita T, Masaki R, etal |title=PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 26868–75 |year= 1996 |pmid= 8900170 |doi=10.1074/jbc.271.43.26868 }}
*{{cite journal | author=Watanabe R, Inoue N, Westfall B, ''et al.'' |title=The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1. |journal=EMBO J. |volume=17 |issue= 4 |pages= 877-85 |year= 1998 |pmid= 9463366 |doi= 10.1093/emboj/17.4.877 }}
*{{cite journal  | author=Watanabe R, Kinoshita T, Masaki R, ''et al.'' |title=PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 26868-75 |year= 1996 |pmid= 8900170 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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{{gene-16-stub}}

Latest revision as of 18:07, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene.[1][2][3]

This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI).[3]

Interactions

PIGQ has been shown to interact with PIGH,[1] PIGA[1] and PIGC.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 Watanabe R, Inoue N, Westfall B, Taron CH, Orlean P, Takeda J, Kinoshita T (Mar 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMC 1170437. PMID 9463366.
  2. ↑ Tiede A, Schubert J, Nischan C, Jensen I, Westfall B, Taron CH, Orlean P, Schmidt RE (Nov 1998). "Human and mouse Gpi1p homologues restore glycosylphosphatidylinositol membrane anchor biosynthesis in yeast mutants". Biochem J. 334 (3): 609–16. PMC 1219730. PMID 9729469.
  3. ↑ 3.0 3.1 "Entrez Gene: PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q".

Further reading



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