PEX16: Difference between revisions
Jump to navigation
Jump to search
m (Bot: HTTP→HTTPS) |
imported>Bibcode Bot m (Adding 0 arxiv eprint(s), 2 bibcode(s) and 0 doi(s). Did it miss something? Report bugs, errors, and suggestions at User talk:Bibcode Bot) |
||
| Line 20: | Line 20: | ||
*{{cite journal |vauthors=Fransen M, Brees C, Ghys K, etal |title=Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay |journal=Mol. Cell. Proteomics |volume=1 |issue= 3 |pages= 243–52 |year= 2002 |pmid= 12096124 |doi=10.1074/mcp.M100025-MCP200 }} | *{{cite journal |vauthors=Fransen M, Brees C, Ghys K, etal |title=Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay |journal=Mol. Cell. Proteomics |volume=1 |issue= 3 |pages= 243–52 |year= 2002 |pmid= 12096124 |doi=10.1074/mcp.M100025-MCP200 }} | ||
*{{cite journal |vauthors=Honsho M, Hiroshige T, Fujiki Y |title=The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44513–24 |year= 2003 |pmid= 12223482 |doi= 10.1074/jbc.M206139200 }} | *{{cite journal |vauthors=Honsho M, Hiroshige T, Fujiki Y |title=The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44513–24 |year= 2003 |pmid= 12223482 |doi= 10.1074/jbc.M206139200 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Jones JM, Morrell JC, Gould SJ |title=PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins |journal=J. Cell Biol. |volume=164 |issue= 1 |pages= 57–67 |year= 2004 |pmid= 14709540 |doi= 10.1083/jcb.200304111 | pmc=2171958 }} | *{{cite journal |vauthors=Jones JM, Morrell JC, Gould SJ |title=PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins |journal=J. Cell Biol. |volume=164 |issue= 1 |pages= 57–67 |year= 2004 |pmid= 14709540 |doi= 10.1083/jcb.200304111 | pmc=2171958 }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Fransen M, Vastiau I, Brees C, etal |title=Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis |journal=J. Mol. Biol. |volume=346 |issue= 5 |pages= 1275–86 |year= 2005 |pmid= 15713480 |doi= 10.1016/j.jmb.2005.01.013 }} | *{{cite journal |vauthors=Fransen M, Vastiau I, Brees C, etal |title=Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis |journal=J. Mol. Biol. |volume=346 |issue= 5 |pages= 1275–86 |year= 2005 |pmid= 15713480 |doi= 10.1016/j.jmb.2005.01.013 }} | ||
*{{cite journal |vauthors=Brocard CB, Boucher KK, Jedeszko C, etal |title=Requirement for microtubules and dynein motors in the earliest stages of peroxisome biogenesis |journal=Traffic |volume=6 |issue= 5 |pages= 386–95 |year= 2005 |pmid= 15813749 |doi= 10.1111/j.1600-0854.2005.00283.x }} | *{{cite journal |vauthors=Brocard CB, Boucher KK, Jedeszko C, etal |title=Requirement for microtubules and dynein motors in the earliest stages of peroxisome biogenesis |journal=Traffic |volume=6 |issue= 5 |pages= 386–95 |year= 2005 |pmid= 15813749 |doi= 10.1111/j.1600-0854.2005.00283.x }} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
*{{cite journal |vauthors=Kim PK, Mullen RT, Schumann U, Lippincott-Schwartz J |title=The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER |journal=J. Cell Biol. |volume=173 |issue= 4 |pages= 521–32 |year= 2006 |pmid= 16717127 |doi= 10.1083/jcb.200601036 | pmc=2063862 }} | *{{cite journal |vauthors=Kim PK, Mullen RT, Schumann U, Lippincott-Schwartz J |title=The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER |journal=J. Cell Biol. |volume=173 |issue= 4 |pages= 521–32 |year= 2006 |pmid= 16717127 |doi= 10.1083/jcb.200601036 | pmc=2063862 }} | ||
{{refend}} | {{refend}} | ||
Latest revision as of 19:41, 25 June 2018
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.[1][2]
Function
The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described.[2]
Interactions
PEX16 has been shown to interact with PEX19.[3]
References
- ↑ South ST, Gould SJ (Mar 1999). "Peroxisome Synthesis in the Absence of Preexisting Peroxisomes". J Cell Biol. 144 (2): 255–66. doi:10.1083/jcb.144.2.255. PMC 2132891. PMID 9922452.
- ↑ 2.0 2.1 "Entrez Gene: PEX16 peroxisomal biogenesis factor 16".
- ↑ Fransen, M; Wylin T; Brees C; Mannaerts G P; Van Veldhoven P P (Jul 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. United States. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669.
Further reading
- Honsho M, Tamura S, Shimozawa N, et al. (1999). "Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D". Am. J. Hum. Genet. 63 (6): 1622–30. doi:10.1086/302161. PMC 1377633. PMID 9837814.
- Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
- Fransen M, Wylin T, Brees C, et al. (2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.
- Shimozawa N, Nagase T, Takemoto Y, et al. (2002). "A novel aberrant splicing mutation of the PEX16 gene in two patients with Zellweger syndrome". Biochem. Biophys. Res. Commun. 292 (1): 109–12. doi:10.1006/bbrc.2002.6642. PMID 11890679.
- Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell. Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
- Honsho M, Hiroshige T, Fujiki Y (2003). "The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly". J. Biol. Chem. 277 (46): 44513–24. doi:10.1074/jbc.M206139200. PMID 12223482.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Jones JM, Morrell JC, Gould SJ (2004). "PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins". J. Cell Biol. 164 (1): 57–67. doi:10.1083/jcb.200304111. PMC 2171958. PMID 14709540.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Fransen M, Vastiau I, Brees C, et al. (2005). "Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis". J. Mol. Biol. 346 (5): 1275–86. doi:10.1016/j.jmb.2005.01.013. PMID 15713480.
- Brocard CB, Boucher KK, Jedeszko C, et al. (2005). "Requirement for microtubules and dynein motors in the earliest stages of peroxisome biogenesis". Traffic. 6 (5): 386–95. doi:10.1111/j.1600-0854.2005.00283.x. PMID 15813749.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Kim PK, Mullen RT, Schumann U, Lippincott-Schwartz J (2006). "The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER". J. Cell Biol. 173 (4): 521–32. doi:10.1083/jcb.200601036. PMC 2063862. PMID 16717127.
External links
- GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
- OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
 | This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it. |