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{{Infobox_gene}}
'''Protein deglycase DJ-1''', also known as '''Parkinson disease protein 7''', is a [[protein]] which in humans is encoded by the ''PARK7'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PARK7 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11315| accessdate = }}</ref>


== Structure ==


=== Gene ===


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The gene ''PARK7'', also known as ''DJ-1'', encodes a protein of the peptidase C56 family. The human gene ''PARK7'' has 8 Exons and locates at chromosome band 1p36.23.<ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
=== Protein ===
{{GNF_Protein_box
The human protein deglycase DJ-1 is 20 kDa in size and composed of 189 amino acids with seven [[β-strand]]s and nine [[α-helices]] in total and is present as a [[protein dimer|dimer]].<ref>{{cite web|title=Uniprot: Q99497 - PARK7_HUMAN|url=http://www.uniprot.org/uniprot/Q99497}}</ref><ref>{{cite journal | vauthors = Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F | title = The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease | journal = The Journal of Biological Chemistry | volume = 278 | issue = 33 | pages = 31380–4 | date = Aug 2003 | pmid = 12796482 | doi = 10.1074/jbc.M305878200 }}</ref><ref>{{cite journal | vauthors = Tao X, Tong L | title = Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease | journal = The Journal of Biological Chemistry | volume = 278 | issue = 33 | pages = 31372–9 | date = Aug 2003 | pmid = 12761214 | doi = 10.1074/jbc.M304221200 }}</ref> It belongs to the [[peptidase]] C56 family of proteins.
| image = PBB_Protein_PARK7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1j42.
| PDB = {{PDB2|1j42}}, {{PDB2|1p5f}}, {{PDB2|1pdv}}, {{PDB2|1pdw}}, {{PDB2|1pe0}}, {{PDB2|1ps4}}, {{PDB2|1q2u}}, {{PDB2|1soa}}, {{PDB2|1ucf}}, {{PDB2|2or3}}
| Name = Parkinson disease (autosomal recessive, early onset) 7
| HGNCid = 16369
| Symbol = PARK7
| AltSymbols =; DJ-1; DJ1; FLJ27376
| OMIM = 602533
| ECnumber = 
| Homologene = 38295
| MGIid = 2135637
| GeneAtlas_image1 = PBB_GE_PARK7_200007_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0008344 |text = adult locomotory behavior}} {{GNF_GO|id=GO:0042542 |text = response to hydrogen peroxide}} {{GNF_GO|id=GO:0051583 |text = dopamine uptake}}  
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11315
    | Hs_Ensembl = ENSG00000116288
    | Hs_RefseqProtein = NP_009193
    | Hs_RefseqmRNA = NM_007262
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 7944310
    | Hs_GenLoc_end = 7968152
    | Hs_Uniprot = Q99497
    | Mm_EntrezGene = 57320
    | Mm_Ensembl = ENSMUSG00000028964
    | Mm_RefseqmRNA = NM_020569
    | Mm_RefseqProtein = NP_065594
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 149740942
    | Mm_GenLoc_end = 149753650
    | Mm_Uniprot = Q3THB9
  }}
}}
'''Parkinson disease (autosomal recessive, early onset) 7''', also known as '''PARK7''', is a human [[gene]].  It is also known as DJ-1.


==See also==
The protein structures of human protein DJ-1, Escherichia coli chaperone Hsp31 and an Archaea protease are evolutionarily conserved.<ref>{{cite journal | vauthors = Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS | title = Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 45 | pages = 44552–9 | date = Nov 2003 | pmid = 12939276 | doi = 10.1074/jbc.M304517200 }}</ref>
 
== Function ==
 
Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity,<ref>{{cite journal | vauthors = Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A | title = DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation | journal = PLoS Biology | volume = 2 | issue = 11 | pages = e362 | date = Nov 2004 | pmid = 15502874 | doi = 10.1371/journal.pbio.0020362 | pmc=521177}}</ref><ref>{{cite journal | vauthors = Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL | title = The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein | journal = Journal of Molecular Biology | volume = 356 | issue = 4 | pages = 1036–48 | date = Mar 2006 | pmid = 16403519 | doi = 10.1016/j.jmb.2005.12.030 }}</ref> thus functions as a redox-sensitive chaperone and as a sensor for [[oxidative stress]]. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death.<ref name="entrez"/> In parallel, Protein DJ-1 acts as a positive regulator of [[androgen receptor]]-dependent transcription.
 
[[Pyrroloquinoline quinone]] (PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of [[Parkinson's disease]].<ref>{{cite journal | vauthors = Nunome K, Miyazaki S, Nakano M, Iguchi-Ariga S, Ariga H | title = Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1 | journal = Biological & Pharmaceutical Bulletin | volume = 31 | issue = 7 | pages = 1321–6 | date = Jul 2008 | pmid = 18591768 | doi = 10.1248/bpb.31.1321 }}</ref>
 
Functional DJ-1 protein has been shown to bind metals and protect against metal-induced cytotoxicity from [[copper]] and [[mercury]].<ref name="pmid23792957">{{cite journal| author=Björkblom B, Adilbayeva A, Maple-Grødem J, Piston D, Ökvist M, Xu XM et al.| title=Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. | journal=J Biol Chem | year= 2013 | volume= 288 | issue= 31 | pages= 22809-20 | pmid=23792957 | doi=10.1074/jbc.M113.482091 | pmc=3829365 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23792957  }} </ref>
 
== Clinical significance ==
 
Defects in this gene are the cause of autosomal recessive early-onset [[Parkinson's disease]] 7.<ref name="entrez"/><ref name="pmid 12446870">{{cite journal | vauthors = Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P | title = Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism | journal = Science | volume = 299 | issue = 5604 | pages = 256–9 | date = Jan 2003 | pmid = 12446870 | doi = 10.1126/science.1077209 }}</ref>
 
== Interactions ==
 
PARK7 has been shown to [[Protein-protein interaction|interact]] with:
* [[CASK]],<ref name="pmid25071438">{{cite journal | vauthors = Mukherjee K, Slawson JB, Christmann BL, Griffith LC | title = Neuron-specific protein interactions of Drosophila CASK-β are revealed by mass spectrometry | journal = Frontiers in Molecular Neuroscience | volume = 7 | issue =  | pages = 58 | year = 2014 | pmid = 25071438 | pmc = 4075472 | doi = 10.3389/fnmol.2014.00058 }}</ref>
* [[EFCAB6]],<ref name = pmid12612053>{{cite journal | vauthors = Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H | title = DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex | journal = Molecular Cancer Research | volume = 1 | issue = 4 | pages = 247–61 | date = Feb 2003 | pmid = 12612053 | doi =  }}</ref>  and
* [[Protein inhibitor of activated STAT2|PIAS2]].<ref name = pmid11477070>{{cite journal | vauthors = Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H | title = DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 40 | pages = 37556–63 | date = Oct 2001 | pmid = 11477070 | doi = 10.1074/jbc.M101730200 }}</ref>
 
== See also ==
*[[Parkinson's disease]]
*[[Parkinson's disease]]
{{Clear}}


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== References ==
{{PBB_Summary
{{Reflist|33em}}
| section_title =
| summary_text =
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==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cookson MR | title = Pathways to Parkinsonism | journal = Neuron | volume = 37 | issue = 1 | pages = 7–10 | date = Jan 2003 | pmid = 12526767 | doi = 10.1016/S0896-6273(02)01166-2 }}
| citations =
* {{cite journal | vauthors = Bonifati V, Oostra BA, Heutink P | title = Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease | journal = Journal of Molecular Medicine | volume = 82 | issue = 3 | pages = 163–74 | date = Mar 2004 | pmid = 14712351 | doi = 10.1007/s00109-003-0512-1 }}
*{{cite journal | author=Cookson MR |title=Pathways to Parkinsonism. |journal=Neuron |volume=37 |issue= 1 |pages= 7-10 |year= 2003 |pmid= 12526767 |doi= }}
* {{cite journal | vauthors = Le W, Appel SH | title = Mutant genes responsible for Parkinson's disease | journal = Current Opinion in Pharmacology | volume = 4 | issue = 1 | pages = 79–84 | date = Feb 2004 | pmid = 15018843 | doi = 10.1016/j.coph.2003.09.005 }}
*{{cite journal | author=Bonifati V, Oostra BA, Heutink P |title=Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. |journal=J. Mol. Med. |volume=82 |issue= 3 |pages= 163-74 |year= 2004 |pmid= 14712351 |doi= 10.1007/s00109-003-0512-1 }}
* {{cite journal | vauthors = Abou-Sleiman PM, Healy DG, Wood NW | title = Causes of Parkinson's disease: genetics of DJ-1 | journal = Cell and Tissue Research | volume = 318 | issue = 1 | pages = 185–8 | date = Oct 2004 | pmid = 15503154 | doi = 10.1007/s00441-004-0922-6 }}
*{{cite journal | author=Le W, Appel SH |title=Mutant genes responsible for Parkinson's disease. |journal=Current opinion in pharmacology |volume=4 |issue= 1 |pages= 79-84 |year= 2004 |pmid= 15018843 |doi= 10.1016/j.coph.2003.09.005 }}
* {{cite journal | vauthors = Pankratz N, Foroud T | title = Genetics of Parkinson disease | journal = NeuroRx | volume = 1 | issue = 2 | pages = 235–42 | date = Apr 2004 | pmid = 15717024 | pmc = 534935 | doi = 10.1602/neurorx.1.2.235 }}
*{{cite journal | author=Abou-Sleiman PM, Healy DG, Wood NW |title=Causes of Parkinson's disease: genetics of DJ-1. |journal=Cell Tissue Res. |volume=318 |issue= 1 |pages= 185-8 |year= 2005 |pmid= 15503154 |doi= 10.1007/s00441-004-0922-6 }}
* {{cite journal | vauthors = Heutink P | title = PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease | journal = Journal of Neural Transmission. Supplementum | volume = 70 | issue = 70 | pages = 215–9 | year = 2006 | pmid = 17017532 | doi = 10.1007/978-3-211-45295-0_33 | isbn = 978-3-211-28927-3 | series = Journal of Neural Transmission. Supplementa }}
*{{cite journal | author=Pankratz N, Foroud T |title=Genetics of Parkinson disease. |journal=NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics |volume=1 |issue= 2 |pages= 235-42 |year= 2005 |pmid= 15717024 |doi= }}
* {{cite journal | vauthors = Lev N, Roncevic D, Roncevich D, Ickowicz D, Melamed E, Offen D | title = Role of DJ-1 in Parkinson's disease | journal = Journal of Molecular Neuroscience | volume = 29 | issue = 3 | pages = 215–25 | year = 2007 | pmid = 17085780 | doi = 10.1385/JMN:29:3:215 }}
*{{cite journal | author=Heutink P |title=PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease. |journal=J. Neural Transm. Suppl. |volume= |issue= 70 |pages= 215-9 |year= 2006 |pmid= 17017532 |doi= }}
* {{cite journal | vauthors = Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H | title = DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras | journal = Biochemical and Biophysical Research Communications | volume = 231 | issue = 2 | pages = 509–13 | date = Feb 1997 | pmid = 9070310 | doi = 10.1006/bbrc.1997.6132 }}
*{{cite journal | author=Lev N, Roncevic D, Roncevich D, ''et al.'' |title=Role of DJ-1 in Parkinson's disease. |journal=J. Mol. Neurosci. |volume=29 |issue= 3 |pages= 215-25 |year= 2007 |pmid= 17085780 |doi= }}
* {{cite journal | vauthors = Taira T, Takahashi K, Kitagawa R, Iguchi-Ariga SM, Ariga H | title = Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter | journal = Gene | volume = 263 | issue = 1-2 | pages = 285–92 | date = Jan 2001 | pmid = 11223268 | doi = 10.1016/S0378-1119(00)00590-4 }}
*{{cite journal | author=Nagakubo D, Taira T, Kitaura H, ''et al.'' |title=DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. |journal=Biochem. Biophys. Res. Commun. |volume=231 |issue= 2 |pages= 509-13 |year= 1997 |pmid= 9070310 |doi= 10.1006/bbrc.1997.6132 }}
* {{cite journal | vauthors = van Duijn CM, Dekker MC, Bonifati V, Galjaard RJ, Houwing-Duistermaat JJ, Snijders PJ, Testers L, Breedveld GJ, Horstink M, Sandkuijl LA, van Swieten JC, Oostra BA, Heutink P | title = Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36 | journal = American Journal of Human Genetics | volume = 69 | issue = 3 | pages = 629–34 | date = Sep 2001 | pmid = 11462174 | pmc = 1235491 | doi = 10.1086/322996 }}
*{{cite journal | author=Taira T, Takahashi K, Kitagawa R, ''et al.'' |title=Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter. |journal=Gene |volume=263 |issue= 1-2 |pages= 285-92 |year= 2001 |pmid= 11223268 |doi= }}
* {{cite journal | vauthors = Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H | title = DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 40 | pages = 37556–63 | date = Oct 2001 | pmid = 11477070 | doi = 10.1074/jbc.M101730200 }}
*{{cite journal | author=van Duijn CM, Dekker MC, Bonifati V, ''et al.'' |title=Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. |journal=Am. J. Hum. Genet. |volume=69 |issue= 3 |pages= 629-34 |year= 2001 |pmid= 11462174 |doi= }}
* {{cite journal | vauthors = Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P | title = Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism | journal = Science | volume = 299 | issue = 5604 | pages = 256–9 | date = Jan 2003 | pmid = 12446870 | doi = 10.1126/science.1077209 }}
*{{cite journal | author=Takahashi K, Taira T, Niki T, ''et al.'' |title=DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37556-63 |year= 2001 |pmid= 11477070 |doi= 10.1074/jbc.M101730200 }}
* {{cite journal | vauthors = Bonifati V, Dekker MC, Vanacore N, Fabbrini G, Squitieri F, Marconi R, Antonini A, Brustenghi P, Dalla Libera A, De Mari M, Stocchi F, Montagna P, Gallai V, Rizzu P, van Swieten JC, Oostra B, van Duijn CM, Meco G, Heutink P | title = Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7 | journal = Neurological Sciences | volume = 23 Suppl 2 | issue =  | pages = S59-60 | date = Sep 2002 | pmid = 12548343 | doi = 10.1007/s100720200069 }}
*{{cite journal | author=Bonifati V, Rizzu P, van Baren MJ, ''et al.'' |title=Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. |journal=Science |volume=299 |issue= 5604 |pages= 256-9 |year= 2003 |pmid= 12446870 |doi= 10.1126/science.1077209 }}
* {{cite journal | vauthors = Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H | title = DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex | journal = Molecular Cancer Research | volume = 1 | issue = 4 | pages = 247–61 | date = Feb 2003 | pmid = 12612053 | doi = }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Tao X, Tong L | title = Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease | journal = The Journal of Biological Chemistry | volume = 278 | issue = 33 | pages = 31372–9 | date = Aug 2003 | pmid = 12761214 | doi = 10.1074/jbc.M304221200 }}
*{{cite journal | author=Bonifati V, Dekker MC, Vanacore N, ''et al.'' |title=Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7. |journal=Neurol. Sci. |volume=23 Suppl 2 |issue= |pages= S59-60 |year= 2003 |pmid= 12548343 |doi= 10.1007/s100720200069 }}
* {{cite journal | vauthors = Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F | title = The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease | journal = The Journal of Biological Chemistry | volume = 278 | issue = 33 | pages = 31380–4 | date = Aug 2003 | pmid = 12796482 | doi = 10.1074/jbc.M305878200 }}
*{{cite journal | author=Niki T, Takahashi-Niki K, Taira T, ''et al.'' |title=DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. |journal=Mol. Cancer Res. |volume=1 |issue= 4 |pages= 247-61 |year= 2004 |pmid= 12612053 |doi= }}
* {{cite journal | vauthors = Dekker M, Bonifati V, van Swieten J, Leenders N, Galjaard RJ, Snijders P, Horstink M, Heutink P, Oostra B, van Duijn C | title = Clinical features and neuroimaging of PARK7-linked parkinsonism | journal = Movement Disorders | volume = 18 | issue = 7 | pages = 751–7 | date = Jul 2003 | pmid = 12815653 | doi = 10.1002/mds.10422 }}
*{{cite journal | author=Tao X, Tong L |title=Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 31372-9 |year= 2003 |pmid= 12761214 |doi= 10.1074/jbc.M304221200 }}
* {{cite journal | vauthors = Miller DW, Ahmad R, Hague S, Baptista MJ, Canet-Aviles R, McLendon C, Carter DM, Zhu PP, Stadler J, Chandran J, Klinefelter GR, Blackstone C, Cookson MR | title = L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36588–95 | date = Sep 2003 | pmid = 12851414 | doi = 10.1074/jbc.M304272200 }}
*{{cite journal | author=Honbou K, Suzuki NN, Horiuchi M, ''et al.'' |title=The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 31380-4 |year= 2003 |pmid= 12796482 |doi= 10.1074/jbc.M305878200 }}
*{{cite journal | author=Dekker M, Bonifati V, van Swieten J, ''et al.'' |title=Clinical features and neuroimaging of PARK7-linked parkinsonism. |journal=Mov. Disord. |volume=18 |issue= 7 |pages= 751-7 |year= 2004 |pmid= 12815653 |doi= 10.1002/mds.10422 }}
*{{cite journal  | author=Miller DW, Ahmad R, Hague S, ''et al.'' |title=L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36588-95 |year= 2003 |pmid= 12851414 |doi= 10.1074/jbc.M304272200 }}
}}
{{refend}}
{{refend}}


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Revision as of 01:11, 22 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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View/Edit Human

Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene.[1]

Structure

Gene

The gene PARK7, also known as DJ-1, encodes a protein of the peptidase C56 family. The human gene PARK7 has 8 Exons and locates at chromosome band 1p36.23.[1]

Protein

The human protein deglycase DJ-1 is 20 kDa in size and composed of 189 amino acids with seven β-strands and nine α-helices in total and is present as a dimer.[2][3][4] It belongs to the peptidase C56 family of proteins.

The protein structures of human protein DJ-1, Escherichia coli chaperone Hsp31 and an Archaea protease are evolutionarily conserved.[5]

Function

Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity,[6][7] thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death.[1] In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription.

Pyrroloquinoline quinone (PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of Parkinson's disease.[8]

Functional DJ-1 protein has been shown to bind metals and protect against metal-induced cytotoxicity from copper and mercury.[9]

Clinical significance

Defects in this gene are the cause of autosomal recessive early-onset Parkinson's disease 7.[1][10]

Interactions

PARK7 has been shown to interact with:

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 "Entrez Gene: PARK7".
  2. ↑ "Uniprot: Q99497 - PARK7_HUMAN".
  3. ↑ Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F (Aug 2003). "The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease". The Journal of Biological Chemistry. 278 (33): 31380–4. doi:10.1074/jbc.M305878200. PMID 12796482.
  4. ↑ Tao X, Tong L (Aug 2003). "Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease". The Journal of Biological Chemistry. 278 (33): 31372–9. doi:10.1074/jbc.M304221200. PMID 12761214.
  5. ↑ Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS (Nov 2003). "Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain". The Journal of Biological Chemistry. 278 (45): 44552–9. doi:10.1074/jbc.M304517200. PMID 12939276.
  6. ↑ Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A (Nov 2004). "DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation". PLoS Biology. 2 (11): e362. doi:10.1371/journal.pbio.0020362. PMC 521177. PMID 15502874.
  7. ↑ Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL (Mar 2006). "The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein". Journal of Molecular Biology. 356 (4): 1036–48. doi:10.1016/j.jmb.2005.12.030. PMID 16403519.
  8. ↑ Nunome K, Miyazaki S, Nakano M, Iguchi-Ariga S, Ariga H (Jul 2008). "Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1". Biological & Pharmaceutical Bulletin. 31 (7): 1321–6. doi:10.1248/bpb.31.1321. PMID 18591768.
  9. ↑ Björkblom B, Adilbayeva A, Maple-Grødem J, Piston D, Ökvist M, Xu XM; et al. (2013). "Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity". J Biol Chem. 288 (31): 22809–20. doi:10.1074/jbc.M113.482091. PMC 3829365. PMID 23792957.
  10. ↑ Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P (Jan 2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism". Science. 299 (5604): 256–9. doi:10.1126/science.1077209. PMID 12446870.
  11. ↑ Mukherjee K, Slawson JB, Christmann BL, Griffith LC (2014). "Neuron-specific protein interactions of Drosophila CASK-β are revealed by mass spectrometry". Frontiers in Molecular Neuroscience. 7: 58. doi:10.3389/fnmol.2014.00058. PMC 4075472. PMID 25071438.
  12. ↑ Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (Feb 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Molecular Cancer Research. 1 (4): 247–61. PMID 12612053.
  13. ↑ Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (Oct 2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". The Journal of Biological Chemistry. 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070.

Further reading

  • Cookson MR (Jan 2003). "Pathways to Parkinsonism". Neuron. 37 (1): 7–10. doi:10.1016/S0896-6273(02)01166-2. PMID 12526767.
  • Bonifati V, Oostra BA, Heutink P (Mar 2004). "Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease". Journal of Molecular Medicine. 82 (3): 163–74. doi:10.1007/s00109-003-0512-1. PMID 14712351.
  • Le W, Appel SH (Feb 2004). "Mutant genes responsible for Parkinson's disease". Current Opinion in Pharmacology. 4 (1): 79–84. doi:10.1016/j.coph.2003.09.005. PMID 15018843.
  • Abou-Sleiman PM, Healy DG, Wood NW (Oct 2004). "Causes of Parkinson's disease: genetics of DJ-1". Cell and Tissue Research. 318 (1): 185–8. doi:10.1007/s00441-004-0922-6. PMID 15503154.
  • Pankratz N, Foroud T (Apr 2004). "Genetics of Parkinson disease". NeuroRx. 1 (2): 235–42. doi:10.1602/neurorx.1.2.235. PMC 534935. PMID 15717024.
  • Heutink P (2006). "PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease". Journal of Neural Transmission. Supplementum. Journal of Neural Transmission. Supplementa. 70 (70): 215–9. doi:10.1007/978-3-211-45295-0_33. ISBN 978-3-211-28927-3. PMID 17017532.
  • Lev N, Roncevic D, Roncevich D, Ickowicz D, Melamed E, Offen D (2007). "Role of DJ-1 in Parkinson's disease". Journal of Molecular Neuroscience. 29 (3): 215–25. doi:10.1385/JMN:29:3:215. PMID 17085780.
  • Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (Feb 1997). "DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras". Biochemical and Biophysical Research Communications. 231 (2): 509–13. doi:10.1006/bbrc.1997.6132. PMID 9070310.
  • Taira T, Takahashi K, Kitagawa R, Iguchi-Ariga SM, Ariga H (Jan 2001). "Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter". Gene. 263 (1–2): 285–92. doi:10.1016/S0378-1119(00)00590-4. PMID 11223268.
  • van Duijn CM, Dekker MC, Bonifati V, Galjaard RJ, Houwing-Duistermaat JJ, Snijders PJ, Testers L, Breedveld GJ, Horstink M, Sandkuijl LA, van Swieten JC, Oostra BA, Heutink P (Sep 2001). "Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36". American Journal of Human Genetics. 69 (3): 629–34. doi:10.1086/322996. PMC 1235491. PMID 11462174.
  • Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (Oct 2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". The Journal of Biological Chemistry. 276 (40): 37556–63. doi:10.1074/jbc.M101730200. PMID 11477070.
  • Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P (Jan 2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism". Science. 299 (5604): 256–9. doi:10.1126/science.1077209. PMID 12446870.
  • Bonifati V, Dekker MC, Vanacore N, Fabbrini G, Squitieri F, Marconi R, Antonini A, Brustenghi P, Dalla Libera A, De Mari M, Stocchi F, Montagna P, Gallai V, Rizzu P, van Swieten JC, Oostra B, van Duijn CM, Meco G, Heutink P (Sep 2002). "Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7". Neurological Sciences. 23 Suppl 2: S59–60. doi:10.1007/s100720200069. PMID 12548343.
  • Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (Feb 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Molecular Cancer Research. 1 (4): 247–61. PMID 12612053.
  • Tao X, Tong L (Aug 2003). "Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease". The Journal of Biological Chemistry. 278 (33): 31372–9. doi:10.1074/jbc.M304221200. PMID 12761214.
  • Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F (Aug 2003). "The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease". The Journal of Biological Chemistry. 278 (33): 31380–4. doi:10.1074/jbc.M305878200. PMID 12796482.
  • Dekker M, Bonifati V, van Swieten J, Leenders N, Galjaard RJ, Snijders P, Horstink M, Heutink P, Oostra B, van Duijn C (Jul 2003). "Clinical features and neuroimaging of PARK7-linked parkinsonism". Movement Disorders. 18 (7): 751–7. doi:10.1002/mds.10422. PMID 12815653.
  • Miller DW, Ahmad R, Hague S, Baptista MJ, Canet-Aviles R, McLendon C, Carter DM, Zhu PP, Stadler J, Chandran J, Klinefelter GR, Blackstone C, Cookson MR (Sep 2003). "L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system". The Journal of Biological Chemistry. 278 (38): 36588–95. doi:10.1074/jbc.M304272200. PMID 12851414.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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