PAH clearance

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Para aminohippurate clearance or PAH clearance is a method used in renal physiology to measure renal plasma flow, which, in turn, is a measure of renal function.

The concentration of para aminohippurate (PAH) is measured in one arterial blood sample (P_PAH) and one urine sample(U_PAH). The urine flow (V) as also measured. Renal perfusion flow is then calculated by:

<math>RPF = \frac{U_{PAH}}{P_{PAH}} V</math>

What in fact is calculated is the effective renal plasma flow (eRPF). However, since the renal extraction ratio of PAH almost equals 1, then eRPF almost equals RPF.

Precision

The renal extraction ratio of PAH is a normal individual is approximately 0.92, and thus not exactly 1.0. Thus, this method usually underestimates RPF by approximately 10%. This margin of error is generally acceptable considering the ease with which eRPF is measured.