Non-alcoholic fatty liver disease

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Non-Alcoholic Fatty Liver Disease Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

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CT

MRI

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Other Imaging Findings

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Treatment

Medical Therapy

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Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case studies

Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

For the patient information page on this topic, click here.

Synonyms and keywords: NASH, NAFLD, non alcoholic steatohepatitis

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of NAFLD usually develop in the fourth decade of life.
  • With the raising concern of obesity and metabolic syndrome NAFLD is becoming the most common liver disease in the world.
  • Our understanding of NAFLD natural history is evolving with extensive research and we can classify NAFLD further by prospectively collecting the data with well defined and well designed studies. [1]
  • If left untreated, Patients with NAFLD may progress to develop NASH which is a more serious complication.

Complications

  • Common complications of NAFLD include: [2]
    • NASH
    • Cirrhosis
    • Gastro intestinal bleeding
    • Liver failure
    • Liver cancer

Prognosis

  • Prognosis is generally variable with NAFLD patients.
  • Depending on the NAFLD Activity Score (NAS) of the NAFLD at the time of diagnosis, the prognosis may vary.
  • The presence of fibrosis in NAFLD patients is associated with a particularly poor prognosis.[3]
  • [Subtype of disease/malignancy] is associated with the most favorable prognosis.
  • The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

External Links

  • NIH page on Nonalcoholic Steatohepatitis


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Template:WikiDoc Sources

  1. Goh GB, McCullough AJ (2016). "Natural History of Nonalcoholic Fatty Liver Disease". Dig. Dis. Sci. 61 (5): 1226–33. doi:10.1007/s10620-016-4095-4. PMID 27003142.
  2. "Nonalcoholic Fatty Liver Disease Symptoms, Causes, and More".