Myelofibrosis natural history, complications and prognosis: Difference between revisions

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==Prognosis==
==Prognosis==
*Prognosis of myelofibrosis is poor.
*Prognosis is generally poor and the median survival for myelofibrosis is 3.5 years to 5.5 years, but patients younger than 55 years have a median survival of 11 years.<ref name=diseaseoverviewmf1>Disease overview of primary myelofibrosis. National cancer institute 2016. http://www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#section/_9. Accessed on March 10, 2016</ref>
*The median survival for myelofibrosis is 3.5 years to 5.5 years, but patients younger than 55 years have a median survival of 11 years.<ref name=diseaseoverviewmf1>Disease overview of primary myelofibrosis. National cancer institute 2016. http://www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#section/_9. Accessed on March 10, 2016</ref>
*Poor prognostic factors for myelofibrosis include:<ref name=diseaseoverviewmf1>Disease overview of primary myelofibrosis. National cancer institute 2016. http://www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#section/_9. Accessed on March 10, 2016</ref>
*Poor prognostic factors for myelofibrosis include:
:*Age 65 years or older
:*Age 65 years or older
:*[[Anemia]] (hemoglobin <10 g/dL).
:*[[Anemia]] (hemoglobin <10 g/dL).
:*Constitutional symptoms: [[fever]], [[night sweats]], or [[weight loss]]
:*Constitutional symptoms ([[fever]], [[night sweats]], or [[weight loss]])
:*[[Leukocytosis]] (white blood cell count >25 × 10<sup>9</sup>/L).
:*[[Leukocytosis]] (white blood cell count >25 × 10<sup>9</sup>/L).
:*Circulating blasts of at least 1%.
:*Circulating blasts of at least 1%.

Revision as of 15:11, 10 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Natural History

Myelofibrosis has a very indolent course.[1]

Complications

Common complications of myelofibrosis include:[2][3][4][5]

Prognosis

  • Prognosis is generally poor and the median survival for myelofibrosis is 3.5 years to 5.5 years, but patients younger than 55 years have a median survival of 11 years.[5]
  • Poor prognostic factors for myelofibrosis include:[5]

References

  1. Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016
  2. Complications of myelofibrosis. US National Library of Medicine 2016. https://www.nlm.nih.gov/medlineplus/ency/article/000531.htm. Accessed on March 7, 2016
  3. Signs and symptoms of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 7, 2016
  4. Kelle, Bayram; Yıldız, Fatih; Paydas, Semra; Bagır, Emine Kılıc; Ergin, Melek; Kozanoglu, Erkan (2015). "Coexistence of hypertrophic osteoarthropathy and myelofibrosis". Revista Brasileira de Reumatologia (English Edition). doi:10.1016/j.rbre.2014.11.004. ISSN 2255-5021.
  5. 5.0 5.1 5.2 Disease overview of primary myelofibrosis. National cancer institute 2016. http://www.cancer.gov/types/myeloproliferative/hp/chronic-treatment-pdq#section/_9. Accessed on March 10, 2016


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