Mycosis fungoides history and symptoms: Difference between revisions

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Latest revision as of 17:54, 12 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

The most common symptoms of mycosis fungoides include fever, weight loss, skin rash, night sweats, itching, chest pain, abdominal pain, and bone pain.^[1]

History and Symptoms

History

The majority of patients with mycosis fungoides is present with:^[2]
- Skin patches and plaques
- Skin erythema with or without exfoliation
  - Erythroderma observed patchy or diffuse^[3]
  - Erythroderma observed with cracking or fissuring of the palms and soles.^[3]
- Eczema
- Psoriasis
- Other benign skin disorders
Patients with advanced disease may have a positive history of with cutaneous tumors or nodules or diffuse skin erythema with or without exfoliation.
Skin lesions in the disease obserevedc in non–sunexposed areas (bathing trunk distribution) and lesions may be hyperpigmented or hypopigmented, or may ulcerate.
Tumors
- > 1 cm in size (depth or vertical growth)

Diagnosis criteria from the International Society for Cutaneous Lymphoma is:^[2]^[4]


Criteria	Major( 2pinots)	Minor(1point)
Persistent and/or progressive patches and plaques plus	Any 2	Any 1
Clinical
1. Non–sun-exposed location
2.Size/shape variation
3.Poikiloderma
Histopathologic
Superficial lymphoid infiltrate plus	Both	Either
1. Epidermotropism
2. Atypia
Molecular/biological
Clonal TCR gene rearrangement		Present
Immunopathologic
1. CD2, CD3, CD5 in <59% of T cells		Any 1
2. CD7 in <10% of T cells
3. Epidermal discordance from expression of CD2, CD3, CD5, and CD7 on dermal T cells

Common Symptoms

Symptoms of cutaneous T cell lymphoma include:^[1]

References

↑ ^1.0 ^1.1 Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016
↑ ^2.0 ^2.1 Foss, Francine M.; Girardi, Michael (2017). "Mycosis Fungoides and Sezary Syndrome". Hematology/Oncology Clinics of North America. 31 (2): 297–315. doi:10.1016/j.hoc.2016.11.008. ISSN 0889-8588.
↑ ^3.0 ^3.1 Vonderheid, Eric C.; Bernengo, Maria Grazia; Burg, Günter; Duvic, Madeleine; Heald, Peter; Laroche, Liliane; Olsen, Elise; Pittelkow, Mark; Russell-Jones, Robin; Takigawa, Masahiro; Willemze, Rein (2002). "Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas". Journal of the American Academy of Dermatology. 46 (1): 95–106. doi:10.1067/mjd.2002.118538. ISSN 0190-9622.
↑ Pimpinelli, Nicola; Olsen, Elise A.; Santucci, Marco; Vonderheid, Eric; Haeffner, Andreas C.; Stevens, Seth; Burg, Guenter; Cerroni, Lorenzo; Dreno, Brigitte; Glusac, Earl; Guitart, Joan; Heald, Peter W.; Kempf, Werner; Knobler, Robert; Lessin, Stuart; Sander, Christian; Smoller, Bruce S.; Telang, Gladys; Whittaker, Sean; Iwatsuki, Keiji; Obitz, Erik; Takigawa, Masahiro; Turner, Maria L.; Wood, Gary S. (2005). "Defining early mycosis fungoides". Journal of the American Academy of Dermatology. 53 (6): 1053–1063. doi:10.1016/j.jaad.2005.08.057. ISSN 0190-9622.

Template:WikiDoc Sources

[seer.cancer-1] 1.0 ^1.1 Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016

[FossGirardi2017-2] 2.0 ^2.1 Foss, Francine M.; Girardi, Michael (2017). "Mycosis Fungoides and Sezary Syndrome". Hematology/Oncology Clinics of North America. 31 (2): 297–315. doi:10.1016/j.hoc.2016.11.008. ISSN 0889-8588.

[VonderheidBernengo2002-3] 3.0 ^3.1 Vonderheid, Eric C.; Bernengo, Maria Grazia; Burg, Günter; Duvic, Madeleine; Heald, Peter; Laroche, Liliane; Olsen, Elise; Pittelkow, Mark; Russell-Jones, Robin; Takigawa, Masahiro; Willemze, Rein (2002). "Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas". Journal of the American Academy of Dermatology. 46 (1): 95–106. doi:10.1067/mjd.2002.118538. ISSN 0190-9622.

[PimpinelliOlsen2005-4] Pimpinelli, Nicola; Olsen, Elise A.; Santucci, Marco; Vonderheid, Eric; Haeffner, Andreas C.; Stevens, Seth; Burg, Guenter; Cerroni, Lorenzo; Dreno, Brigitte; Glusac, Earl; Guitart, Joan; Heald, Peter W.; Kempf, Werner; Knobler, Robert; Lessin, Stuart; Sander, Christian; Smoller, Bruce S.; Telang, Gladys; Whittaker, Sean; Iwatsuki, Keiji; Obitz, Erik; Takigawa, Masahiro; Turner, Maria L.; Wood, Gary S. (2005). "Defining early mycosis fungoides". Journal of the American Academy of Dermatology. 53 (6): 1053–1063. doi:10.1016/j.jaad.2005.08.057. ISSN 0190-9622.

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[2]

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[4]

@@ Line 1: / Line 1: @@
-{{Cutaneous T cell lymphoma}}
+__NOTOC__
-{{CMG}}
+{{Mycosis fungoides}}
+{{CMG}}; {{AE}} {{S.G.}}
 ==Overview==
+The most common [[Symptom|symptoms]] of mycosis fungoides include [[fever]], [[weight loss]], [[skin]] [[rash]], [[night sweats]], [[itching]], [[chest pain]], [[abdominal pain]], and [[bone pain]].<ref name="seer.cancer">Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016</ref>
+==History and Symptoms==
+===History===
+*The majority of [[Patient|patients]] with mycosis fungoides is present with:<ref name="FossGirardi2017">{{cite journal|last1=Foss|first1=Francine M.|last2=Girardi|first2=Michael|title=Mycosis Fungoides and Sezary Syndrome|journal=Hematology/Oncology Clinics of North America|volume=31|issue=2|year=2017|pages=297–315|issn=08898588|doi=10.1016/j.hoc.2016.11.008}}</ref>
+**[[Skin]] patches and [[Plaque|plaques]]
+**[[Skin]] [[erythema]] with or without [[exfoliation]]
+***[[Erythroderma]] observed patchy or [[diffuse]]<ref name="VonderheidBernengo2002" />
+***[[Erythroderma]] observed with cracking or fissuring of the palms and soles.<ref name="VonderheidBernengo2002">{{cite journal|last1=Vonderheid|first1=Eric C.|last2=Bernengo|first2=Maria Grazia|last3=Burg|first3=Günter|last4=Duvic|first4=Madeleine|last5=Heald|first5=Peter|last6=Laroche|first6=Liliane|last7=Olsen|first7=Elise|last8=Pittelkow|first8=Mark|last9=Russell-Jones|first9=Robin|last10=Takigawa|first10=Masahiro|last11=Willemze|first11=Rein|title=Update on erythrodermic cutaneous T-cell lymphoma: Report of the international society for cutaneous lymphomas|journal=Journal of the American Academy of Dermatology|volume=46|issue=1|year=2002|pages=95–106|issn=01909622|doi=10.1067/mjd.2002.118538}}</ref>
+**[[Eczema]]
+**[[Psoriasis]]
+**Other [[benign]] [[skin]] [[Disorder (medicine)|disorders]]
+*[[Patient|Patients]] with advanced [[disease]] may have a positive history of with cutaneous tumors or nodules or diffuse skin erythema with or without exfoliation.
+*[[Skin]] [[Lesion|lesions]] in the [[disease]] obserevedc in non–sunexposed areas (bathing trunk distribution) and lesions may be hyperpigmented or hypopigmented, or may ulcerate.
+*[[Tumor|Tumors]]
+**> 1 cm in size (depth or vertical growth)
+Diagnosis criteria from the International Society for Cutaneous Lymphoma is:<ref name="FossGirardi2017" /><ref name="PimpinelliOlsen2005">{{cite journal|last1=Pimpinelli|first1=Nicola|last2=Olsen|first2=Elise A.|last3=Santucci|first3=Marco|last4=Vonderheid|first4=Eric|last5=Haeffner|first5=Andreas C.|last6=Stevens|first6=Seth|last7=Burg|first7=Guenter|last8=Cerroni|first8=Lorenzo|last9=Dreno|first9=Brigitte|last10=Glusac|first10=Earl|last11=Guitart|first11=Joan|last12=Heald|first12=Peter W.|last13=Kempf|first13=Werner|last14=Knobler|first14=Robert|last15=Lessin|first15=Stuart|last16=Sander|first16=Christian|last17=Smoller|first17=Bruce S.|last18=Telang|first18=Gladys|last19=Whittaker|first19=Sean|last20=Iwatsuki|first20=Keiji|last21=Obitz|first21=Erik|last22=Takigawa|first22=Masahiro|last23=Turner|first23=Maria L.|last24=Wood|first24=Gary S.|title=Defining early mycosis fungoides|journal=Journal of the American Academy of Dermatology|volume=53|issue=6|year=2005|pages=1053–1063|issn=01909622|doi=10.1016/j.jaad.2005.08.057}}</ref>
+{| class="wikitable"
+|+
+! style="background: #4479BA; color:#FFF;" |Criteria
+! style="background: #4479BA; color:#FFF;" |Major( 2pinots)
+! style="background: #4479BA; color:#FFF;" |Minor(1point)
+|-
+|'''Persistent and/or progressive patches and plaques plus'''
+|Any 2
+|Any 1
+|-
+| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |Clinical
+|-
+|1. Non–sun-exposed location
+|
+|
+|-
+|2.Size/shape variation
+|
+|
+|-
+|3.Poikiloderma
+|
+|
+|-
+| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Histopathologic'''
+|-
+|Superficial lymphoid infiltrate plus
+|Both
+|Either
+|-
+|1. Epidermotropism
+|
+|
+|-
+|2. Atypia
+|
+|
+|-
+| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Molecular/biological'''
+|-
+|Clonal TCR gene rearrangement
+|
+|Present
+|-
+| colspan="3" style="background: #B0C4DE; color:#FFF;" ! |'''Immunopathologic'''
+|-
+|1. CD2, CD3, CD5 in <59% of T cells
+|
+|Any 1
+|-
+|2. CD7 in <10% of T cells
+|
+|
+|-
+| colspan="3" |3. Epidermal discordance from expression of CD2, CD3, CD5, and CD7 on dermal T cells
+|}
+===Common Symptoms===
+Symptoms of cutaneous T cell lymphoma include:<ref name="seer.cancer" />
+* [[Fever]]
+* [[Weight loss]]
+* [[Night sweats]]
+* [[Skin rash]]
+* [[Chest pain]]
+* [[Itching]]
+* [[Abdominal pain]]
+* [[Bone pain]]
 ==References==
-{{reflist|2}}
+{{Reflist|1}}
 [[Category:Disease]]
 [[Category:Types of cancer]]
 [[Category:Hematology]]
-[[Category:Oncology]]
 {{WikiDoc Help Menu}}
 {{WikiDoc Sources}}
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Hematology]]
+[[Category:Immunology]]