Mycobacterium kansasii

Jump to navigation Jump to search
Mycobacterium kansasii
Scientific classification
Kingdom: Bacteria
Phylum: Actinobacteria
Order: Actinomycetales
Suborder: Corynebacterineae
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: M. kansasii
Binomial name
Mycobacterium kansasii
Hauduroy 1955, ATCC 12478

WikiDoc Resources for Mycobacterium kansasii

Articles

Most recent articles on Mycobacterium kansasii

Most cited articles on Mycobacterium kansasii

Review articles on Mycobacterium kansasii

Articles on Mycobacterium kansasii in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Mycobacterium kansasii

Images of Mycobacterium kansasii

Photos of Mycobacterium kansasii

Podcasts & MP3s on Mycobacterium kansasii

Videos on Mycobacterium kansasii

Evidence Based Medicine

Cochrane Collaboration on Mycobacterium kansasii

Bandolier on Mycobacterium kansasii

TRIP on Mycobacterium kansasii

Clinical Trials

Ongoing Trials on Mycobacterium kansasii at Clinical Trials.gov

Trial results on Mycobacterium kansasii

Clinical Trials on Mycobacterium kansasii at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Mycobacterium kansasii

NICE Guidance on Mycobacterium kansasii

NHS PRODIGY Guidance

FDA on Mycobacterium kansasii

CDC on Mycobacterium kansasii

Books

Books on Mycobacterium kansasii

News

Mycobacterium kansasii in the news

Be alerted to news on Mycobacterium kansasii

News trends on Mycobacterium kansasii

Commentary

Blogs on Mycobacterium kansasii

Definitions

Definitions of Mycobacterium kansasii

Patient Resources / Community

Patient resources on Mycobacterium kansasii

Discussion groups on Mycobacterium kansasii

Patient Handouts on Mycobacterium kansasii

Directions to Hospitals Treating Mycobacterium kansasii

Risk calculators and risk factors for Mycobacterium kansasii

Healthcare Provider Resources

Symptoms of Mycobacterium kansasii

Causes & Risk Factors for Mycobacterium kansasii

Diagnostic studies for Mycobacterium kansasii

Treatment of Mycobacterium kansasii

Continuing Medical Education (CME)

CME Programs on Mycobacterium kansasii

International

Mycobacterium kansasii en Espanol

Mycobacterium kansasii en Francais

Business

Mycobacterium kansasii in the Marketplace

Patents on Mycobacterium kansasii

Experimental / Informatics

List of terms related to Mycobacterium kansasii

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Mycobacterium kansasii

Description

Gram-positive, nonmotile, moderately long to long and acid-fast rods.

Colony characteristics

  • Smooth to rough colonies after 7 or more days of incubation.
  • Colonies grown in dark are nonpigmented, when grown in light or when young colonies are exposed briefly to light, colonies become brilliant yellow (photochromogenic).
  • If grown in a lighted incubator, most strains form dark red crystals of β-carotene on the surface and inside of colony.

Physiology

  • Growth on Middlebrook 7H10 agar at 37°C within 7 days or more.
  • Resistant to isoniazid.
  • Susceptible to ethambutol.

Differential characteristics

  • Closely related to the non-pathogenic, also slowly growing, nonpigmented M. gastri.
  • Both species share an identical 16S rDNA but differentiation is possible by differences in the ITS and hsp65 sequences
  • A commercial hybridisation assay (AccuProbe) to identify M. kansasii exists.

Pathogenesis

  • Chronic human pulmonary disease resembling tuberculosis (involvement of the upper lobe).
  • Extrapulmonary infections, (cervical lymphadenitis in children, cutaneous and soft tissues infections and musculoskeletal system involvement), are uncommon.
  • Rarely causes disseminated disease except in patients with severely impaired cellular immunity (patients with organ transplants or AIDS).
  • Normally considered not to be contagious from person to person.
  • Natural sources of infections unclear. Tap water is believed to be the major reservoir associated with human disease.
  • Biosafety level 2

Type Strain

  • First and most frequently isolated from human pulmonary secretions and lesions.

Strain ATCC 12478 = CIP 104589 = DSM 44162 = JCM 6379 = NCTC 13024.

Treatment

Antimicrobial regimen

  • pulmonary disease
  • Preferred regimen: Rifampin 10 mg/kg/day (maximum, 600 mg) AND Ethambutol 15 mg/kg/ day AND Isoniazid 5 mg/kg/day (maximum 300 mg) AND Pyridoxine 50 mg/day
  • NOTE: Treatment duration for M. kansasii lung disease should include 12 months of negative sputum cultures
  • Rifampin-resistant M. kansasii disease

References

  • Hauduroy,P. 1955. Derniers aspects du monde des mycobactéries. Masson et Cie, Paris, 1955.


de:Mycobacterium kansasii nl:Mycobacterium kansasii

Template:SIB


Template:WikiDoc Sources