Multiple endocrine neoplasia type 2 other diagnostic studies: Difference between revisions
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{{Multiple endocrine neoplasia type 2}} | {{Multiple endocrine neoplasia type 2}} | ||
{{CMG}}; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Other diagnostic studies for multiple endocrine neoplasia type 2 include molecular [[genetic testing]] which include sequence analysis of select exons of mainly 10,11, 13-16 and sequence analysis of ''RET'' gene. | Other diagnostic studies for multiple endocrine neoplasia type 2 include molecular [[genetic testing]] which include sequence analysis of select exons of mainly 10,11, 13-16 and sequence analysis of [[RET proto-oncogene|''RET'' gene]]. | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Molecular Genetic Testing=== | ===Molecular Genetic Testing=== | ||
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! style="background: #F5F5F5;" |Single-gene testing | ! style="background: #F5F5F5;" |Single-gene testing | ||
! style="background: #F5F5F5;" |Sequence analysis of ''RET'' gene | ! style="background: #F5F5F5;" |Sequence analysis of [[RET proto-oncogene|''RET'']] gene | ||
|- | |- | ||
! style="background: #F5F5F5;" |A multi-gene panel | ! style="background: #F5F5F5;" |A multi-gene panel | ||
! style="background: #F5F5F5;" |''RET'' and other genes of interest | ! style="background: #F5F5F5;" |[[RET proto-oncogene|''RET'']] and other genes of interest | ||
|} | |} | ||
===Histopathological Staining of the Biopsy=== | ===Histopathological Staining of the Biopsy=== | ||
* Histopathological staining of medullary thyroid cancer | * Histopathological staining of medullary thyroid cancer<ref>{{Cite journal| author = [[Jessica Marquard]] & [[Charis Eng]] | ||
| title = Multiple Endocrine Neoplasia Type 2 | |||
| year = 1993 | |||
| month = | |||
| pmid = 020301434 | |||
}}</ref> | |||
# [[Calcitonin]]: positive in [[tumor]] [[cell]]s | |||
# [[Chromogranin]]: positive in [[tumor]] [[cell]]s | |||
# [[Synaptophysin]]: positive in [[tumor]] [[cell]]s | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Oncology]] | |||
[[Category:Diseases]] | |||
[[Category:Medicine]] | |||
[[Category:Endocrinology]] | |||
[[Category:Up-To-Date]] | |||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Endocrinology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 02:47, 27 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Other diagnostic studies for multiple endocrine neoplasia type 2 include molecular genetic testing which include sequence analysis of select exons of mainly 10,11, 13-16 and sequence analysis of RET gene.
Other Diagnostic Studies
Molecular Genetic Testing
| Test | Method |
|---|---|
| Select exon testing | Sequence analysis of select exons of mainly 10,11, 13-16 |
| Single-gene testing | Sequence analysis of RET gene |
| A multi-gene panel | RET and other genes of interest |
Histopathological Staining of the Biopsy
- Histopathological staining of medullary thyroid cancer[1]
- Calcitonin: positive in tumor cells
- Chromogranin: positive in tumor cells
- Synaptophysin: positive in tumor cells
References
- ↑ Jessica Marquard & Charis Eng (1993). "Multiple Endocrine Neoplasia Type 2". PMID 020301434.