Multiple endocrine neoplasia type 2 causes: Difference between revisions
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Multiple endocrine neoplasia type 2 is caused by a [[mutation]] in the ''RET'' gene. | Multiple endocrine neoplasia type 2 is caused by a [[mutation]] in the ''RET'' gene. | ||
==Causes== | ==Causes== | ||
Mutations in the [[RET proto-oncogene]] cause multiple endocrine neoplasia type 2. The protein produced by the [[RET proto-oncogene]] gene normally plays an important role in signaling cells to respond to their environment, for example by [[cell division|dividing]] or maturing. Mutations in this gene cause an overactivation of the protein's signaling function, which can lead to an overgrowth of | Mutations in the [[RET proto-oncogene]] cause multiple endocrine neoplasia type 2. The [[protein]] produced by the [[RET proto-oncogene]] gene normally plays an important role in signaling cells to respond to their environment, for example by [[cell division|dividing]] or maturing. Mutations in this [[gene]] cause an overactivation of the [[protein]]'s signaling function, which can lead to an overgrowth of [[cell]]s and the formation of [[tumor]]s characteristic of multiple endocrine neoplasia type 2.<ref>[https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2] MULTIPLE ENDOCRINE NEOPLASIA, TYPE 2; MEN2</ref> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} |
Revision as of 15:10, 28 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Multiple endocrine neoplasia type 2 is caused by a mutation in the RET gene.
Causes
Mutations in the RET proto-oncogene cause multiple endocrine neoplasia type 2. The protein produced by the RET proto-oncogene gene normally plays an important role in signaling cells to respond to their environment, for example by dividing or maturing. Mutations in this gene cause an overactivation of the protein's signaling function, which can lead to an overgrowth of cells and the formation of tumors characteristic of multiple endocrine neoplasia type 2.[1]