Mucoepidermoid carcinoma classification: Difference between revisions

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** High grade  
** High grade  
* The three most popular grading systems are:
* The three most popular grading systems are:
** the AFIP grading system [21],
** the AFIP grading system <ref name="pmid9529011">{{cite journal |vauthors=Goode RK, Auclair PL, Ellis GL |title=Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria |journal=Cancer |volume=82 |issue=7 |pages=1217–24 |date=April 1998 |pmid=9529011 |doi= |url=}}</ref>
**  modified Healey system [22], and
**  modified Healey system<ref name="pmid2221741">{{cite journal |vauthors=Batsakis JG, Luna MA |title=Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas |journal=Ann. Otol. Rhinol. Laryngol. |volume=99 |issue=10 Pt 1 |pages=835–8 |date=October 1990 |pmid=2221741 |doi=10.1177/000348949009901015 |url=}}</ref>
** The Brandwein [23] system (Table 5).  
** The Brandwein<ref name="pmid12484654">{{cite journal |vauthors=Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A |title=Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes |journal=Acta Otolaryngol. |volume=122 |issue=7 |pages=758–64 |date=October 2002 |pmid=12484654 |doi= |url=}}</ref>
* All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion.  
* All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion.  



Revision as of 08:14, 8 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] Maria Fernanda Villarreal, M.D. [3]

Classification: Mucoepidermoid Carcinomas
Adapted from Radiopedia [1]
Salivary gland-confined carcinomas
  • Major salivary glands (50%)
  • Parotid gland (40%)
  • Submandibular gland (7%)
  • Sublingual gland (3%)
  • Minor salivary glands (50%)
  • Palate (most common)
  • Retromolar area
  • Floor of the mouth
  • Buccal mucosa
  • Lip
  • Tongue
Other organ mucoepidermoid carcinomas
  • Thyroid
  • Lung

Overview

Mucoepidermoid carcinoma may be classified according to location into 2 subtypes: salivary gland-confined carcinomas and other organ mucoepidermoid carcinomas.[1]

Classification

Mucoepidermoid carcinoma may be classified according to location into 2 subtypes:

Grading based on Histopathology:

  • Mucoepidermoid carcinoma are graded into three subtypes based on histpathological features:
    • Low
    • Intermediate
    • High grade
  • The three most popular grading systems are:
    • the AFIP grading system [2]
    • modified Healey system[3]
    • The Brandwein[4]
  • All categories are based on similar set of parameters which include both cytomorphologic and architectural, particularly perineural and angiolymphatic invasion.


References

  1. 1.0 1.1 Mucoepidermoid carcinoma. Radiopedia. Dr Frank Gailliard. http://radiopaedia.org/articles/mucoepidermoid-carcinoma-of-salivary-glands Accessed on February 17, 2016
  2. Goode RK, Auclair PL, Ellis GL (April 1998). "Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria". Cancer. 82 (7): 1217–24. PMID 9529011.
  3. Batsakis JG, Luna MA (October 1990). "Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas". Ann. Otol. Rhinol. Laryngol. 99 (10 Pt 1): 835–8. doi:10.1177/000348949009901015. PMID 2221741.
  4. Brandwein MS, Ferlito A, Bradley PJ, Hille JJ, Rinaldo A (October 2002). "Diagnosis and classification of salivary neoplasms: pathologic challenges and relevance to clinical outcomes". Acta Otolaryngol. 122 (7): 758–64. PMID 12484654.

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