Msn2,4p gene transcriptions

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Associate Editor(s)-in-Chief: Henry A. Hoff

"[msn2p] is a transcription factor that binds to stress-response elements (STREs) resulting in the induction of more than 200 genes.10,11 STRE has a core pentameric cis-acting sequence CCCCT and is located in promoter regions of the induced genes."[1]

Human genes

Gene expressions

Interactions

Consensus sequences

The upstream activating sequence (UAS) for the Msn2,4p transcription factor is 5'-CCCCT-3'.[2]

Binding site for

Complement copies

Inverse copies

Complement-inverse copies

Enhancer activity

Promoter occurrences

Hypotheses

  1. A1BG has no regulatory elements in either promoter.
  2. A1BG is not transcribed by a regulatory element.
  3. No regulatory element participates in the transcription of A1BG.

Samplings

Copying CCCCT in "⌘F" yields one between ZSCAN22 and A1BG and three between ZNF497 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence CCCCT (starting with SuccessablesSTRE.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

  1. negative strand, negative direction, looking for CCCCT, 1, CCCCT at 2924.
  2. positive strand, negative direction, looking for CCCCT, 2, CCCCT at 3059, CCCCT at 617.
  3. positive strand, positive direction, looking for CCCCT, 8, CCCCT at 4043, CCCCT at 3665, CCCCT at 3543, CCCCT at 3452, CCCCT at 2657, CCCCT at 1867, CCCCT at 492, CCCCT at 321.
  4. negative strand, positive direction, looking for CCCCT, 2, CCCCT at 3615, CCCCT at 1073.
  5. complement, negative strand, negative direction, looking for GGGGA, 2, GGGGA at 3059, GGGGA at 617.
  6. complement, positive strand, negative direction, looking for GGGGA, 1, GGGGA at 2924.
  7. complement, positive strand, positive direction, looking for GGGGA, 2, GGGGA at 3615, GGGGA at 1073.
  8. complement, negative strand, positive direction, looking for GGGGA, 8, GGGGA at 4043, GGGGA at 3665, GGGGA at 3543, CCCCT at GGGGA, GGGGA at GGGGA, GGGGA at GGGGA, GGGGA at 492, GGGGA at 321.
  9. inverse complement, negative strand, negative direction, looking for AGGGG, 0.
  10. inverse complement, positive strand, negative direction, looking for AGGGG, 0.
  11. inverse complement, positive strand, positive direction, looking for AGGGG, 6, AGGGG at 3555, AGGGG at 3199, AGGGG at 3078, AGGGG at 1072, AGGGG at 174, AGGGG at 84.
  12. inverse complement, negative strand, positive direction, looking for AGGGG, 11, AGGGG at 4435, AGGGG at 3981, AGGGG at 3664, AGGGG at 3654, AGGGG at 3468, AGGGG at 2656, AGGGG at 2291, AGGGG at 1790, AGGGG at 320, AGGGG at 259, AGGGG at 246.
  13. inverse negative strand, negative direction, looking for TCCCC, 0.
  14. inverse positive strand, negative direction, looking for TCCCC, 0.
  15. inverse positive strand, positive direction, looking for TCCCC, 11, TCCCC at 4435, TCCCC at 3981, TCCCC at 3664, TCCCC at 3654, TCCCC at 3468, TCCCC at 2656, TCCCC at 2291, TCCCC at 1790, TCCCC at 320, TCCCC at 259, TCCCC at 246.
  16. inverse negative strand, positive direction, looking for TCCCC, 6, TCCCC at 3555, TCCCC at 3199, TCCCC at 3078, TCCCC at 1072, TCCCC at 174, TCCCC at 84.

Msn UTR gene transcriptions

Negative strand, negative direction: CCCCT at 2924.

Positive strand, negative direction: CCCCT at 3059.

Msn core promoters

Negative strand, positive direction: AGGGG at 4435.

Msn distal promoters

Positive strand, negative direction: CCCCT at 617.

Negative strand, positive direction: AGGGG at 3981, AGGGG at 3664, AGGGG at 3654, CCCCT at 3615, AGGGG at 3468, AGGGG at 2656, AGGGG at 2291, AGGGG at 1790, CCCCT at 1073, AGGGG at 320, AGGGG at 259, AGGGG at 246.

Positive strand, positive direction: CCCCT at 4043, CCCCT at 3665, AGGGG at 3555, CCCCT at 3543, CCCCT at 3452, AGGGG at 3199, AGGGG at 3078, CCCCT at 2657, CCCCT at 1867, AGGGG at 1072, CCCCT at 492, CCCCT at 321, AGGGG at 174, AGGGG at 84.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

See also

References

  1. Sotirios‐Spyridon Vamvakas, John Kapolos, Lambros Farmakis, Gregoria Koskorellou, Fotios Genneos (14 May 2019). "Ser625 of msn2 transcription factor is indispensable for ethanol tolerance and alcoholic fermentation process". Biotechnology Progress. 35 (5): ee2837. doi:10.1002/btpr.2837. Retrieved 6 February 2021.
  2. Hongting Tang, Yanling Wu, Jiliang Deng, Nanzhu Chen, Zhaohui Zheng, Yongjun Wei, Xiaozhou Luo, and Jay D. Keasling (6 August 2020). "Promoter Architecture and Promoter Engineering in Saccharomyces cerevisiae". Metabolites. 10 (8): 320–39. doi:10.3390/metabo10080320. PMID 32781665 Check |pmid= value (help). Retrieved 18 September 2020.

External links