Molluscum contagiosum natural history, complications and prognosis
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Molluscum contagiosum Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Overview
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. Common complications of [disease name] include [complication 1], [complication 2], and [complication 3]. Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
- OR
- Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- Additional Sentences:
- [Disease/malignancy] is associated with a 5 year survival rate of [#]%.
- The presence of metastasis is associated with a particularly poor prognosis among patients with [disease/malignancy]. The 5 year event free survival rate is less than [#]%.
- The [Subtype of disease or malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor: [subtype of disease/malignancy] have the most favorable prognosis.
Natural History
- The natural history of disease details how the disease progresses without treatment.
- Here are a few template sentences you can use: "The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___. The symptoms of (disease name) typically develop ___ years after exposure to ___. Without treatment, the patient will develop symptoms of ___, which will/ may eventually lead to ___.
- The average incubation period ranges from 2 to 7 weeks. In a minority of cases, disease persists for three to five years. [1][2][3]
Complications
- Using lists can be helpful for describing this section.
- You can use these template sentences;
- "Complications that can develop as a result of (disease name) are ___ (describe in list form)".
- "Complications that can develop as a result of the treatment of (disease name) are ___ (describe in list form).
- Next to each complication, provide a brief one sentence description detailing the complication.
- For an example of the complications section in a natural history, complications and prognosis page, click here.
- MC in healthy people is a self-limiting disease, but it will take about 18 months to resolve by its own. Even though it is self-limiting, it is spreading nature, for cosmetic reasons and to accelerate healing, treatment is called for.
- MC is a treatable cause of chronic conjunctivitis or keratoconjunctivitis.
- Gianotti-Crosti like eruptions have been reported in patients with molluscum contagiosum. In one large retrospective study, this phenomenon was diagnosed in 5 percent. Gianotti-Crosti like reactions may portend a higher likelihood of forthcoming clinical improvement. Molluscum dermatitis, inflamed MC lesions, and Gianotti-Crosti syndrome-like reactions (GCLRs) occurred in the same order.[4]
- Inflammatory reactions to MC, including the previously underrecognized GCLR, are common. Treatment of molluscum dermatitis can reduce spread of MC via autoinoculation from scratching, whereas inflamed MC lesions and GCLRs reflect cell-mediated immune responses that may lead to viral clearance.
Prognosis
- This section should detail the prognosis of the disease, both treated and untreated.
- Here are some template sentences; "The prognosis of (disease name) is poor/good with treatment. Without treatment, (disease name) will result in ___. (Disease name) is associated with a 1/5/10 year mortality of __ among patient with ______ (for example high grade lesions). The presence of ___ is associated with a particularly poor prognosis among patients with (disease name).
- For an example of a prognosis section within a natural history, complications and prognosis page, click here.
One in ten children with molluscum contagiosum is likely to have a substantial effect on their quality of life and therefore treatment should be considered for some children, especially those with many lesions or who have been identified as having a severe effect on quality of life. Patients with molluscum contagiosum and their parents need to be given accurate information about the expected natural history of the disorder. Our data provide the most reliable estimates of the expected time to resolution so far and can be used to help set realistic expectations.[5]
References
- ↑ Brown J, Janniger CK, Schwartz RA, Silverberg NB (2006). "Childhood molluscum contagiosum". Int. J. Dermatol. 45 (2): 93–9. doi:10.1111/j.1365-4632.2006.02737.x. PMID 16445494.
- ↑ Butala N, Siegfried E, Weissler A (2013). "Molluscum BOTE sign: a predictor of imminent resolution". Pediatrics. 131 (5): e1650–3. doi:10.1542/peds.2012-2933. PMID 23545377.
- ↑ Lee R, Schwartz RA (2010). "Pediatric molluscum contagiosum: reflections on the last challenging poxvirus infection, Part 1". Cutis. 86 (5): 230–6. PMID 21214122.
- ↑ Berger EM, Orlow SJ, Patel RR, Schaffer JV (2012). "Experience with molluscum contagiosum and associated inflammatory reactions in a pediatric dermatology practice: the bump that rashes". Arch Dermatol. 148 (11): 1257–64. doi:10.1001/archdermatol.2012.2414. PMID 22911012.
- ↑ Olsen JR, Gallacher J, Finlay AY, Piguet V, Francis NA (2015). "Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study". Lancet Infect Dis. 15 (2): 190–5. doi:10.1016/S1473-3099(14)71053-9. PMID 25541478.