Molluscum contagiosum natural history, complications and prognosis: Difference between revisions
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==Complications== | ==Complications== | ||
* Complications that can develop as a result of Molluscum contagiosum is skin scarring (which usually may happen after spontaneous resolution), chronic [[conjunctivitis]] or [[Keratoconjunctivitis|keratoconjunctivitis,]] and rarely [[Gianotti-Crosti syndrome|Gianotti-Crosti]] like eruptions. Inflammatory reactions to molluscum contagiosum [[antigen]], including the previously underrecognized GCLR, has been reported. | * Complications that can develop as a result of Molluscum contagiosum is skin scarring (which usually may happen after spontaneous resolution), chronic [[conjunctivitis]] or [[Keratoconjunctivitis|keratoconjunctivitis,]] and rarely [[Gianotti-Crosti syndrome|Gianotti-Crosti]] like eruptions. Inflammatory reactions to molluscum contagiosum [[antigen]], including the previously underrecognized GCLR, has been reported. | ||
*[[Scarring]] may be associated with [[Eczematous Scaling|eczematous]] patches or [[plaques]] surrounding molluscum contagiosum lesions. | **[[Scarring]] may be associated with [[Eczematous Scaling|eczematous]] patches or [[plaques]] surrounding molluscum contagiosum lesions. | ||
*[[Gianotti-Crosti syndrome|Gianotti-Crosti]] syndrome is characterized by distinct, self-limiting, [[erythematous]], symmetrical, [[Papulovesicular acrolocated syndrome|papulovesicular]] eruptions mainly distributed on the extremities, buttocks and face in young children<ref name="pmid22911012">{{cite journal |vauthors=Berger EM, Orlow SJ, Patel RR, Schaffer JV |title=Experience with molluscum contagiosum and associated inflammatory reactions in a pediatric dermatology practice: the bump that rashes |journal=Arch Dermatol |volume=148 |issue=11 |pages=1257–64 |year=2012 |pmid=22911012 |doi=10.1001/archdermatol.2012.2414 |url=}}</ref><ref name="pmid26751677">{{cite journal |vauthors=Babu TA, Arivazhahan A |title=Gianotti-Crosti Syndrome following immunization in an 18 months old child |journal=Indian Dermatol Online J |volume=6 |issue=6 |pages=413–5 |year=2015 |pmid=26751677 |pmc=4693355 |doi=10.4103/2229-5178.169713 |url=}}</ref>. | **[[Gianotti-Crosti syndrome|Gianotti-Crosti]] syndrome is characterized by distinct, self-limiting, [[erythematous]], symmetrical, [[Papulovesicular acrolocated syndrome|papulovesicular]] eruptions mainly distributed on the extremities, buttocks and face in young children<ref name="pmid22911012">{{cite journal |vauthors=Berger EM, Orlow SJ, Patel RR, Schaffer JV |title=Experience with molluscum contagiosum and associated inflammatory reactions in a pediatric dermatology practice: the bump that rashes |journal=Arch Dermatol |volume=148 |issue=11 |pages=1257–64 |year=2012 |pmid=22911012 |doi=10.1001/archdermatol.2012.2414 |url=}}</ref><ref name="pmid26751677">{{cite journal |vauthors=Babu TA, Arivazhahan A |title=Gianotti-Crosti Syndrome following immunization in an 18 months old child |journal=Indian Dermatol Online J |volume=6 |issue=6 |pages=413–5 |year=2015 |pmid=26751677 |pmc=4693355 |doi=10.4103/2229-5178.169713 |url=}}</ref>. | ||
==Prognosis== | ==Prognosis== | ||
Revision as of 12:49, 15 June 2017
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Molluscum contagiosum Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]
Overview
If left untreated, most of the patients with molluscum contagiosum may resolve the lesions spontaneously. Common complications of molluscum contagiosum include scarring, conjunctivitis, inflammatory reaction to molluscum contagiosum anigen and rarely Gianotti-Crosti like eruptions. Prognosis is generally good.
Natural History
- The symptoms of molluscum contagiosum usually develop 2 to 7 weeks after exposure but may range from 1 week to 6 months, with a mean of 6 weeks.
- Molluscum contagiosum start with symptoms such as rash and pruritis.
- Molluscum contagiosum is a self limited disease that can be resolved even without treatment.
- Occasionally, disease may persists for three to five years. [1][2][3]
- Diagnosis is made on the clinical appearance.
Complications
- Complications that can develop as a result of Molluscum contagiosum is skin scarring (which usually may happen after spontaneous resolution), chronic conjunctivitis or keratoconjunctivitis, and rarely Gianotti-Crosti like eruptions. Inflammatory reactions to molluscum contagiosum antigen, including the previously underrecognized GCLR, has been reported.
- Scarring may be associated with eczematous patches or plaques surrounding molluscum contagiosum lesions.
- Gianotti-Crosti syndrome is characterized by distinct, self-limiting, erythematous, symmetrical, papulovesicular eruptions mainly distributed on the extremities, buttocks and face in young children[4][5].
Prognosis
The prognosis of molluscum contagiosum is good even without treatment. Sometimes, molluscum contagiosum will result in scarring. The presence of atopic dermatitis is associated with a particularly poor prognosis and higher chance of scar development among patients with molluscum contagiosum.
Treatment should be considered for some children as statistics show one in ten children with molluscum contagiosum may have a substantial effect on their quality of life, especially those with many lesions or who have been identified as having a severe effect on quality of life.[6]
References
- ↑ Brown J, Janniger CK, Schwartz RA, Silverberg NB (2006). "Childhood molluscum contagiosum". Int. J. Dermatol. 45 (2): 93–9. doi:10.1111/j.1365-4632.2006.02737.x. PMID 16445494.
- ↑ Butala N, Siegfried E, Weissler A (2013). "Molluscum BOTE sign: a predictor of imminent resolution". Pediatrics. 131 (5): e1650–3. doi:10.1542/peds.2012-2933. PMID 23545377.
- ↑ Lee R, Schwartz RA (2010). "Pediatric molluscum contagiosum: reflections on the last challenging poxvirus infection, Part 1". Cutis. 86 (5): 230–6. PMID 21214122.
- ↑ Berger EM, Orlow SJ, Patel RR, Schaffer JV (2012). "Experience with molluscum contagiosum and associated inflammatory reactions in a pediatric dermatology practice: the bump that rashes". Arch Dermatol. 148 (11): 1257–64. doi:10.1001/archdermatol.2012.2414. PMID 22911012.
- ↑ Babu TA, Arivazhahan A (2015). "Gianotti-Crosti Syndrome following immunization in an 18 months old child". Indian Dermatol Online J. 6 (6): 413–5. doi:10.4103/2229-5178.169713. PMC 4693355. PMID 26751677.
- ↑ Olsen JR, Gallacher J, Finlay AY, Piguet V, Francis NA (2015). "Time to resolution and effect on quality of life of molluscum contagiosum in children in the UK: a prospective community cohort study". Lancet Infect Dis. 15 (2): 190–5. doi:10.1016/S1473-3099(14)71053-9. PMID 25541478.