Molluscum contagiosum natural history, complications and prognosis

Molluscum contagiosum Microchapters
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Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Molluscum contagiosum from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic criteria
History and Symptoms
Physical Examination
Laboratory Findings
X ray
Ultrasound
CT Scan
MRI
Other Imaging Studies
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2]

Overview

• The overview section should include the disease name in the first sentence.
• The goal is to summarize the entire page in several sentences. This section can be the same as the natural history, complications and prognosis segment on the overview page.
• To see an example, click here.

Template

• First Sentences:

If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. Common complications of [disease name] include [complication 1], [complication 2], and [complication 3]. Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.

OR

Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.

• Examples:

Example 1: If left untreated, 20% to 30% of patients with IgA nephropathy may progress to develop ESRD. Common complications of IgA nephropathy include pro-thrombotic states, such as stroke and myocardial infarction. Prognosis is generally good, and the 5-year mortality rate of patients with IgA nephropathy is approximately 5%.

• Additional Sentences:

[Disease/malignancy] is associated with a 5 year survival rate of [#]%.

The presence of metastasis is associated with a particularly poor prognosis among patients with [disease/malignancy]. The 5 year event free survival rate is less than [#]%.

The [Subtype of disease or malignancy] is associated with the most favorable prognosis.

The prognosis varies with the [characteristic] of tumor: [subtype of disease/malignancy] have the most favorable prognosis.

• Examples:

Example 1: Rhabdomyosarcoma is associated with a 5 year survival rate of 72%.

Example 2: The presence of metastasis is associated with a particularly poor prognosis among patients with rhabdomyosarcoma. The 5 year event free survival rate is less than 30%.

Example 3: The embryonal subtype of rhabdomyosarcoma is associated with the most favorable prognosis.

Example 4: The prognosis varies with the location of tumor: orbital and genitourinary tract rhabdomyosarcomas have the most favorable prognosis.

Natural History

• The natural history of disease details how the disease progresses without treatment.
• Here are a few template sentences you can use: "The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___. The symptoms of (disease name) typically develop ___ years after exposure to ___. Without treatment, the patient will develop symptoms of ___, which will/ may eventually lead to ___.
• The average incubation period ranges from 2 to 7 weeks. 

Complications

• Using lists can be helpful for describing this section.
• You can use these template sentences;
  • "Complications that can develop as a result of (disease name) are ___ (describe in list form)".
  • "Complications that can develop as a result of the treatment of (disease name) are ___ (describe in list form).
  • Next to each complication, provide a brief one sentence description detailing the complication.
• For an example of the complications section in a natural history, complications and prognosis page, click here.
• MC in healthy people is a self-limiting disease, but it will take about 18 months to resolve by its own. Even though it is self-limiting, it is spreading nature, for cosmetic reasons and to accelerate healing, treatment is called for.

Prognosis

• This section should detail the prognosis of the disease, both treated and untreated.
• Here are some template sentences; "The prognosis of (disease name) is poor/good with treatment. Without treatment, (disease name) will result in ___. (Disease name) is associated with a 1/5/10 year mortality of __ among patient with ______ (for example high grade lesions). The presence of ___ is associated with a particularly poor prognosis among patients with (disease name).
• For an example of a prognosis section within a natural history, complications and prognosis page, click here.

One in ten children with molluscum contagiosum is likely to have a substantial effect on their quality of life and therefore treatment should be considered for some children, especially those with many lesions or who have been identified as having a severe effect on quality of life. Patients with molluscum contagiosum and their parents need to be given accurate information about the expected natural history of the disorder. Our data provide the most reliable estimates of the expected time to resolution so far and can be used to help set realistic expectations.

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