Methylene blue: Difference between revisions
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===Dosage=== | ===Dosage=== | ||
0.1 to 0.2 mL per kilogram of body weight (0.045 to 0.09 mL per pound of body weight). Inject Methylene Blue intravenously very slowly over a period of several minutes. | 0.1 to 0.2 mL per kilogram of body weight (0.045 to 0.09 mL per pound of body weight). Inject Methylene Blue intravenously very slowly over a period of several minutes. | ||
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Methylene blue in adult patients. | |offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Methylene blue in adult patients. | ||
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Methylene blue in adult patients. | |offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Methylene blue in adult patients. | ||
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|clinicalTrials=Large intravenous doses of Methylene Blue produce nausea, abdominal and precordial pain, dizziness, headache, profuse sweating, mental confusion and the formation of methemoglobin. | |clinicalTrials=Large intravenous doses of Methylene Blue produce nausea, abdominal and precordial pain, dizziness, headache, profuse sweating, mental confusion and the formation of methemoglobin. | ||
|useInPregnancyFDA=Safety for use in pregnancy has not been established. Use of Methylene Blue in women of childbearing potential requires that anticipated benefits be weighed against possible hazards. | |useInPregnancyFDA=Safety for use in pregnancy has not been established. Use of Methylene Blue in women of childbearing potential requires that anticipated benefits be weighed against possible hazards. | ||
|drugBox={{chembox | |||
| Watchedfields = changed | |||
| verifiedrevid = 476992187 | |||
| Name = Methylene blue | |||
| ImageFile = Methylene_blue.png | |||
| ImageSize = 220px | |||
| ImageName = Methylene blue | |||
| ImageFile1 = Methylene-blue-ox-3D-vdW.png | |||
| ImageSize1 = | |||
| ImageName1 = Space-filling model of methylene blue in its oxidised form | |||
| IUPACName = 3,7-bis(Dimethylamino)-<br />phenothiazin-5-ium chloride | |||
| OtherNames = C.I. 52015 | |||
|Section1={{Chembox Identifiers | |||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | |||
| ChemSpiderID = 5874 | |||
| UNII_Ref = {{fdacite|correct|FDA}} | |||
| UNII = 8NAP7826UB | |||
| InChI1 = 1/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1 | |||
| InChIKey1 = CXKWCBBOMKCUKX-REWHXWOFAR | |||
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChI = 1S/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1 | |||
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | |||
| StdInChIKey = CXKWCBBOMKCUKX-UHFFFAOYSA-M | |||
| CASNo = 61-73-4 | |||
| CASNo_Ref = {{cascite|correct|CAS}} | |||
| ChEBI_Ref = {{ebicite|correct|EBI}} | |||
| ChEBI = 6872 | |||
| SMILES = CN(C)c1ccc2c(c1)sc-3cc(=[N+](C)C)ccc3n2.[Cl-] | |||
| ChEMBL_Ref = {{ebicite|correct|EBI}} | |||
| ChEMBL = 405110 | |||
| PubChem =6099 | |||
| ATCCode_prefix = V03 | |||
| ATCCode_suffix = AB17 | |||
| ATC_Supplemental = {{ATC|V04|CG05}} | |||
}} | |||
|mechAction=*Methylene blue is Phenothiazin-5-ium, 3,7-bis (dimethylamino)-, chloride, trihydrate. It will produce two opposite actions on hemoglobin. Low concentrations will convert methemoglobin to hemoglobin. High concentrations convert the ferrous iron of reduced hemoglobin to ferric iron which results in the formation of methemoglobin. | |||
|structure=*Methylene Blue Injection, USP is a sterile solution of methylene blue in water for injection suitable for parenteral administration. | |||
[[File:Methylenblue1.jpeg|thumb|none|400px|This image is provided by the National Library of Medicine.]] | |||
*Each mL of solution contains 10 mg of methylene blue and water for injection q.s. pH adjusted with hydrochloric acid and/or sodium hydroxide when necessary. | |||
|howSupplied=Methylene Blue Injection, USP, 1% is supplied as follows: | |howSupplied=Methylene Blue Injection, USP, 1% is supplied as follows: | ||
Revision as of 19:47, 22 April 2015
{{DrugProjectFormSinglePage |genericName=Methylene blue |indicationType=treatment |indication=Drug induced methemoglobinemia |blackBoxWarningTitle=TITLE |blackBoxWarningBody=Condition Name: (Content) |fdaLIADAdult====Indications=== Drug induced methemoglobinemia
Dosage
0.1 to 0.2 mL per kilogram of body weight (0.045 to 0.09 mL per pound of body weight). Inject Methylene Blue intravenously very slowly over a period of several minutes. |offLabelAdultGuideSupport=There is limited information regarding Off-Label Guideline-Supported Use of Methylene blue in adult patients. |offLabelAdultNoGuideSupport=There is limited information regarding Off-Label Non–Guideline-Supported Use of Methylene blue in adult patients. |offLabelPedGuideSupport=There is limited information regarding Off-Label Guideline-Supported Use of Methylene blue in pediatric patients. |offLabelPedNoGuideSupport=There is limited information regarding Off-Label Non–Guideline-Supported Use of Methylene blue in pediatric patients. |contraindications=Intraspinal injection is contraindicated. |warnings=Methylene Blue should not be given by subcutaneous or intrathecal injection. |clinicalTrials=Large intravenous doses of Methylene Blue produce nausea, abdominal and precordial pain, dizziness, headache, profuse sweating, mental confusion and the formation of methemoglobin. |useInPregnancyFDA=Safety for use in pregnancy has not been established. Use of Methylene Blue in women of childbearing potential requires that anticipated benefits be weighed against possible hazards. |drugBox=
Template:Chembox E number
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| Names | |
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| IUPAC names
3,7-bis(Dimethylamino)-
phenothiazin-5-ium chloride | |
| Other names
C.I. 52015
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| Identifiers | |
3D model (JSmol)
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| ECHA InfoCard | Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). |
PubChem CID
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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