https://www.wikidoc.org/index.php?title=Metabolic_disorder&feed=atom&action=historyMetabolic disorder - Revision history2024-03-29T00:59:34ZRevision history for this page on the wikiMediaWiki 1.40.0https://www.wikidoc.org/index.php?title=Metabolic_disorder&diff=679477&oldid=prevWikiBot: Robot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +)2012-08-09T17:20:56Z<p>Robot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +)</p>
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==Overview==<br />
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A '''metabolic disorder''' is a medical disorder which affects the production of energy within individual human (or animal) [[cell (biology)|cells]]. Most ''metabolic disorders'' are [[genetic disorder|genetic]], though a few are "acquired" as a result of diet, [[toxin]]s, [[infection]]s, etc. Genetic metabolic disorders are also known as [[inborn errors of metabolism]].<br />
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In general, the genetic ''metabolic disorders'' are caused by genetic defects that result in missing or improperly constructed [[enzyme]]s necessary for some step in the metabolic process of the cell.<br />
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The largest classes of ''metabolic disorders'' are:<br />
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* Disorders of carbohydrate metabolism<br />
* Disorders of amino acid metabolism<br />
* Disorders of organic acid metabolism (organic acidurias)<br />
* Disorders of fatty acid oxidation and mitochondrial metabolism<br />
* Disorders of porphyrin metabolism<br />
* Disorders of purine or pyrimidine metabolism<br />
* Disorders of steroid metabolism<br />
* Disorders of mitochondrial function<br />
* Disorders of peroxisomal function<br />
* Lysosomal storage disorders<br />
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''(for further details, see [[inborn errors of metabolism]])''<br />
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A fourth class, the [[channelopathy|channelopathies]] (some of which cause [[periodic paralysis]] and/or [[malignant hyperthermia]]) could be considered to be ''metabolic disorders'' as well, though they are not always classified as such. These disorders affect the [[ion channel]]s in the cell and [[organelle]] [[inner membrane|membrane]]s, resulting in improper or inefficient transfer of [[ion]]s through the membranes.<br />
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There are also a number of other ''metabolic disorders'' (such as [[myoadenylate deaminase deficiency]]) which do not cleanly fit into any of the above classifications.<br />
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{{Endocrine, nutritional and metabolic pathology}}<br />
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[[Category:Metabolic disorders|*]]<br />
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[[de:Stoffwechselstörung]]<br />
[[fr:Maladie métabolique]]<br />
[[id:Penyakit metabolik]]<br />
[[zh:代謝疾病]]<br />
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