Mesoblastic nephroma overview: Difference between revisions
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There are no established risk factors for mesoblastic nephroma. | There are no established risk factors for mesoblastic nephroma. | ||
==Screening== | |||
According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine [[screening]] for mesoblastic nephroma.<ref>Mesoblastic nephroma. U.S. Preventive Service Task Force (USPSTF) 2015. http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=mesoblastic+nephroma Accessed on November, 3, 2015 </ref> | |||
==References== | ==References== | ||
Revision as of 19:10, 5 November 2015
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Mesoblastic nephroma Microchapters |
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Mesoblastic nephroma overview On the Web |
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American Roentgen Ray Society Images of Mesoblastic nephroma overview |
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Risk calculators and risk factors for Mesoblastic nephroma overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Mesoblastic nephroma is a type of kidney tumor.
Classification
Mesoblastic nephroma may be classified according to pathology into three subtypes: classic, cellular, and mixed mesoblastic nephroma.[1]
Pathophysiology
On gross pathology, a solid nonencapsulated mass that often occurs near the renal hilum is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, spindle cell is the characteristic finding of classic mesoblastic nephroma; whereas, plump cells with vesicular nuclei is the characteristic finding of cellular mesoblastic nephroma.[2]
Causes
Mesoblastic nephroma may be caused by translocation t(12:15)(p13;q25) that generates the fusion of ETV6/NTRK3 gene.[3]
Differential diagnosis
Mesoblastic nephroma must be differentiated from rhabdoid tumor, clear cell sarcoma of the kidney, and Wilm's tumor.
Epidemiology and Demographics
Mesoblastic nephroma is a rare disease that tends to affect children under 3 years of age, especially neonates. [4][5] The male to female ratio is approximately 2 to 1.[6]
Risk Factors
There are no established risk factors for mesoblastic nephroma.
Screening
According to the the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for mesoblastic nephroma.[7]
References
- ↑ Malkan AD, Loh A, Bahrami A, et al. (2015). "An approach to renal masses in pediatrics". Pediatrics. 135 (1): 142–58. doi:10.1542/peds.2014-1011. PMID 25452658.
- ↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
- ↑ Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.
- ↑ Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma
- ↑ Tavassoli, Fattaneh (2003). Pathology and genetics of tumours of the breast and female genital organs. Lyon: IAPS Press. ISBN 9283224124.
- ↑ Furtwaengler R, Reinhard H, Leuschner I, Schenk JP, Goebel U, Claviez A; et al. (2006). "Mesoblastic nephroma--a report from the Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH)". Cancer. 106 (10): 2275–83. doi:10.1002/cncr.21836. PMID 16596620.
- ↑ Mesoblastic nephroma. U.S. Preventive Service Task Force (USPSTF) 2015. http://www.uspreventiveservicestaskforce.org/BrowseRec/Search?s=mesoblastic+nephroma Accessed on November, 3, 2015