Merkel cell cancer surgery: Difference between revisions
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{{CMG}} ; {{AE}} {{VKG}} | {{CMG}} ; {{AE}} {{VKG}} | ||
==Overview== | ==Overview== | ||
The predominant therapy for | The predominant therapy for merkel cell cancer is surgical resection. | ||
==Surgery== | ==Surgery== | ||
*The initial standard approach for patients with | *The initial standard approach for patients with merkel cell cancer is '''wide excision'''. | ||
*According to:<ref name="pmid26257075">{{cite journal |vauthors=Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C |title=Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline |journal=Eur. J. Cancer |volume=51 |issue=16 |pages=2396–403 |date=November 2015 |pmid=26257075 |doi=10.1016/j.ejca.2015.06.131 |url=}}</ref> | *According to:<ref name="pmid26257075">{{cite journal |vauthors=Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C |title=Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline |journal=Eur. J. Cancer |volume=51 |issue=16 |pages=2396–403 |date=November 2015 |pmid=26257075 |doi=10.1016/j.ejca.2015.06.131 |url=}}</ref> | ||
**European Dermatology Forum (EDF) | **European Dermatology Forum (EDF) | ||
**European Association of Dermato-Oncology (EADO) | **European Association of Dermato-Oncology (EADO) | ||
**European Organization of Research and Treatment of Cancer (EORTC) the primary tumour should be excised a margin of at least 1 to 2 cm of healthy tissue surrounding it | **European Organization of Research and Treatment of Cancer (EORTC) the primary tumour should be excised a margin of at least 1 to 2 cm of healthy tissue surrounding it. | ||
*Overall survival rate in patients with | *Overall survival rate in patients with merkel cell cancer increases dramatically by achieving negative margins during excision of the tumour.<ref name="pmid11231196">{{cite journal |vauthors=Tai PT, Yu E, Tonita J, Gilchrist J |title=Merkel cell carcinoma of the skin |journal=J Cutan Med Surg |volume=4 |issue=4 |pages=186–95 |date=October 2000 |pmid=11231196 |doi=10.1177/120347540000400403 |url=}}</ref> | ||
*Regional [[Lymphatic system#Secondary lymphoid organs|lymph nodes]] are often resection because they may contain [[cancer cells]]. | *Regional [[Lymphatic system#Secondary lymphoid organs|lymph nodes]] are often resection because they may contain [[cancer cells]]. | ||
Latest revision as of 19:22, 31 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
The predominant therapy for merkel cell cancer is surgical resection.
Surgery
- The initial standard approach for patients with merkel cell cancer is wide excision.
- According to:[1]
- European Dermatology Forum (EDF)
- European Association of Dermato-Oncology (EADO)
- European Organization of Research and Treatment of Cancer (EORTC) the primary tumour should be excised a margin of at least 1 to 2 cm of healthy tissue surrounding it.
- Overall survival rate in patients with merkel cell cancer increases dramatically by achieving negative margins during excision of the tumour.[2]
- Regional lymph nodes are often resection because they may contain cancer cells.
Mohs micrographic surgery
- Mohs micrographic surgery is indicated when considered cosmetic outcomes especially on sensitive body parts like face.[3][4]
References
- ↑ Lebbe C, Becker JC, Grob JJ, Malvehy J, Del Marmol V, Pehamberger H, Peris K, Saiag P, Middleton MR, Bastholt L, Testori A, Stratigos A, Garbe C (November 2015). "Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline". Eur. J. Cancer. 51 (16): 2396–403. doi:10.1016/j.ejca.2015.06.131. PMID 26257075.
- ↑ Tai PT, Yu E, Tonita J, Gilchrist J (October 2000). "Merkel cell carcinoma of the skin". J Cutan Med Surg. 4 (4): 186–95. doi:10.1177/120347540000400403. PMID 11231196.
- ↑ O'Connor WJ, Roenigk RK, Brodland DG (October 1997). "Merkel cell carcinoma. Comparison of Mohs micrographic surgery and wide excision in eighty-six patients". Dermatol Surg. 23 (10): 929–33. PMID 9357504.
- ↑ Boyer JD, Zitelli JA, Brodland DG, D'Angelo G (December 2002). "Local control of primary Merkel cell carcinoma: review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation". J. Am. Acad. Dermatol. 47 (6): 885–92. doi:10.1067/mjd.2002.125083. PMID 12451374.