Merkel cell cancer overview: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 9: Line 9:
[[Merkel cell]] was first discovered by Freidrich Sigmund Merkel and also mentioned by Cyril Toker, in 1972.Merkel cell polyomavirus, the pathogen responsible for Merkel cell cancer, was first discovered in 2008.
[[Merkel cell]] was first discovered by Freidrich Sigmund Merkel and also mentioned by Cyril Toker, in 1972.Merkel cell polyomavirus, the pathogen responsible for Merkel cell cancer, was first discovered in 2008.
==Classification==
==Classification==
[[Merkel cell carcinoma]] is classified into 3 subgroups: Trabecular, intermediate, and small cell.
Merkel cell carcinoma is classified into 3 subgroups: Trabecular, intermediate, and small cell.


==Pathophysiology==
==Pathophysiology==
It is understood that [[merkel cell cancer]] is the result caused by either [[merkel cell]] [[polyomavirus]], [[ultraviolet]] (UV), [[radiation exposure]] and [[immunosuppression]].
It is understood that merkel cell cancer is the result caused by either [[merkel cell]] [[polyomavirus]], [[ultraviolet]] (UV), [[radiation exposure]] and [[immunosuppression]].


==Causes==
==Causes==

Revision as of 19:26, 31 January 2019

Merkel cell cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Merkel Cell Cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Merkel cell cancer overview On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Merkel cell cancer overview

All Images
X-rays
Echo and Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Merkel cell cancer overview

CDC on Merkel cell cancer overview

Merkel cell cancer overview in the news

Blogs on Merkel cell cancer overview

Directions to Hospitals Treating Merkel cell cancer

Risk calculators and risk factors for Merkel cell cancer overview

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2] Ahmad Al Maradni, M.D. [3]

Overview

Merkel cell carcinoma is a very rare and highly aggressive cutaneous cancer. This cancer is a type of neuroendocrine tumor, like small cell lung cancer. Merkel cell carcinoma is the most serious form of skin cancer. when merkel cell carcinoma metastasized to the lymph nodes, the average 5-year survival rate for a patient with merkel cell carcinoma is less than 50 percent. Recurrence may occur in up to half of all the patients with merkel cell carcinoma. Merkel cell cancer usually occurs on either the face, head, or neck. Patients with merkel cell carcinoma usually present with a rapid growing, firm, painless, red/violaceous skin lesion. Merkel cell carcinoma usually metastasizes first to regional lymph nodes and then to other organs, and spreads to other parts of the body, especially the liver, lungs, brain and bones. The predominant therapy for merkel cell carcinoma is surgical resection, but chemoradiation may also be required in more advanced disease.

Historical Perspective

Merkel cell was first discovered by Freidrich Sigmund Merkel and also mentioned by Cyril Toker, in 1972.Merkel cell polyomavirus, the pathogen responsible for Merkel cell cancer, was first discovered in 2008.

Classification

Merkel cell carcinoma is classified into 3 subgroups: Trabecular, intermediate, and small cell.

Pathophysiology

It is understood that merkel cell cancer is the result caused by either merkel cell polyomavirus, ultraviolet (UV), radiation exposure and immunosuppression.

Causes

Common causes of merkel cell carcinoma include merkel cell polyomavirus, age, skin tone, exposure to sunlight and history of immunosuppression.

Differential Diagnosis

Merkel cell cancer must be differentiated from other skin lesions, such as basal cell carcinoma, squamous cell carcinoma, malignant melanoma, lymphoma, vascular tumors, and other benign skin tumors.

Epidemiology and Demographics

The incidence of merkel cell carcinoma ranges from 0.15 to 0.44 per 100,000 individuals. The median age at diagnosis is approximately 65 years. Merkel cell carcinoma is more common among males and individuals of Caucasian race.

Risk Factors

Risk factors for the development of merkel cell cancer include old age, male gender, caucasian race, chronic exposure to sunlight, immunodeficiency, and personal history of cancer.

Screening

According to the U.S. Preventive Service Task Force (USPSTF), there is insufficient evidence to recommend routine screening for skin cancers, including merkel cell cancer.

Natural History, Complications and Prognosis

Merkel cell cancer is an aggressive cutaneous cancer that grows very rapidly. Merkel cell cancer usually metastasizes first to regional lymph nodes. Merkel cell cancer is a highly aggressive tumor with a mortality rate that approaches 30% to 40% within 3 years of diagnosis.

Diagnosis

Staging

The staging of merkel cell cancer is based on the TNM staging system.

History and Symptoms

Patients with merkel cell carcinoma usually present with a rapid growing, painless, small mass that is typically located on sun exposed area of the body.

Physical Examination

Physical exam findings of merkel cell cancer include red/violaceous skin mass that appear in sun exposed areas.

Laboratory Findings

Laboratory findings consistent with the diagnosis of merkel cell cancer include immunohistochemistry, cytogenetic and molecular analysis, and lymph node biopsy. .

CT

CT scan is useful in detecting metastasis to organs and regional lymph nodes in merkel cell carcinoma.

Other Imaging Findings

Positron emission tomography (PET) imaging may be used for the staging of merkel cell cancer.

Other Diagnostic Studies

Other diagnostic studies for merkel cell cancer include skin biopsy, which demonstrates positive cytokeratin-20 , and electron microscopy, which demonstrates granules, and cytoplasmic extensions.

Treatment

Medical Therapy

The predominant therapy for merkel cell cancerr is surgical resection. Adjunctive chemoradiation and adjuvant immunotherapy may also be required in more advanced disease.

Surgery

The majority of cases of Merkel cell cancer are treated with surgery.

Primary Prevention

Primary prevention of merkel cell cancer includes avoidance of excessive sun exposure and use of sunscreen.

Secondary Prevention

There are no established measures for the secondary prevention of merkel cell cancer.

References


Template:WikiDoc Sources