Merkel cell cancer causes: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
Line 3: Line 3:
{{CMG}} ; {{AE}} {{VKG}}
{{CMG}} ; {{AE}} {{VKG}}
==Overview==
==Overview==
Common causes of [[merkel cell carcinoma]] include [[merkel cell]] [[polyomavirus]], age, skin tone, exposure to [[sunlight]] and history of [[immunosuppression]].
Common causes of merkel cell carcinoma include [[merkel cell]] [[polyomavirus]], age, skin tone, exposure to [[sunlight]] and history of [[immunosuppression]].
==Cause==
==Cause==
=== Common Causes ===
=== Common Causes ===
Line 11: Line 11:
** Especially MCPvy
** Especially MCPvy
* [[Sunlight]]<ref name="pmid10067813">{{cite journal |vauthors=Miller RW, Rabkin CS |title=Merkel cell carcinoma and melanoma: etiological similarities and differences |journal=Cancer Epidemiol. Biomarkers Prev. |volume=8 |issue=2 |pages=153–8 |date=February 1999 |pmid=10067813 |doi= |url=}}</ref>
* [[Sunlight]]<ref name="pmid10067813">{{cite journal |vauthors=Miller RW, Rabkin CS |title=Merkel cell carcinoma and melanoma: etiological similarities and differences |journal=Cancer Epidemiol. Biomarkers Prev. |volume=8 |issue=2 |pages=153–8 |date=February 1999 |pmid=10067813 |doi= |url=}}</ref>
** [[Ultraviolet radiation]] especially [[UVB radiation|UVB]] plays an important role in the developing [[merkel cell carcinoma]]
** [[Ultraviolet radiation]] especially [[UVB radiation|UVB]] plays an important role in the developing [[merkel cell carcinoma]].
* Skin tone<ref name="pmid145766612">{{cite journal |vauthors=Agelli M, Clegg LX |title=Epidemiology of primary Merkel cell carcinoma in the United States |journal=J. Am. Acad. Dermatol. |volume=49 |issue=5 |pages=832–41 |date=November 2003 |pmid=14576661 |doi=10.1067/S0190 |url=}}</ref>
* Skin tone<ref name="pmid145766612">{{cite journal |vauthors=Agelli M, Clegg LX |title=Epidemiology of primary Merkel cell carcinoma in the United States |journal=J. Am. Acad. Dermatol. |volume=49 |issue=5 |pages=832–41 |date=November 2003 |pmid=14576661 |doi=10.1067/S0190 |url=}}</ref>
** Fair skin people are more prone to [[merkel cell carcinoma]]  
** Fair skin people are more prone to [[merkel cell carcinoma]].
* [[Immunosuppression]]: Especially patients with <ref name="pmid25575645">{{cite journal |vauthors=Clarke CA, Robbins HA, Tatalovich Z, Lynch CF, Pawlish KS, Finch JL, Hernandez BY, Fraumeni JF, Madeleine MM, Engels EA |title=Risk of merkel cell carcinoma after solid organ transplantation |journal=J. Natl. Cancer Inst. |volume=107 |issue=2 |pages= |date=February 2015 |pmid=25575645 |pmc=4311175 |doi=10.1093/jnci/dju382 |url=}}</ref><ref name="pmid10609948">{{cite journal |vauthors=Penn I, First MR |title=Merkel's cell carcinoma in organ recipients: report of 41 cases |journal=Transplantation |volume=68 |issue=11 |pages=1717–21 |date=December 1999 |pmid=10609948 |doi= |url=}}</ref><ref name="pmid11853800">{{cite journal |vauthors=Engels EA, Frisch M, Goedert JJ, Biggar RJ, Miller RW |title=Merkel cell carcinoma and HIV infection |journal=Lancet |volume=359 |issue=9305 |pages=497–8 |date=February 2002 |pmid=11853800 |doi=10.1016/S0140-6736(02)07668-7 |url=}}</ref><ref name="pmid17651025">{{cite journal |vauthors=Manganoni MA, Farisoglio C, Tucci G, Venturini M, Marocolo D, Aquilano MC, El-Hamad I, Ferrari VD, Calzavara Pinton PG |title=Merkel cell carcinoma and HIV infection: a case report and review of the literature |journal=AIDS Patient Care STDS |volume=21 |issue=7 |pages=447–51 |date=July 2007 |pmid=17651025 |doi=10.1089/apc.2006.0152 |url=}}</ref>
* [[Immunosuppression]]: Especially patients with <ref name="pmid25575645">{{cite journal |vauthors=Clarke CA, Robbins HA, Tatalovich Z, Lynch CF, Pawlish KS, Finch JL, Hernandez BY, Fraumeni JF, Madeleine MM, Engels EA |title=Risk of merkel cell carcinoma after solid organ transplantation |journal=J. Natl. Cancer Inst. |volume=107 |issue=2 |pages= |date=February 2015 |pmid=25575645 |pmc=4311175 |doi=10.1093/jnci/dju382 |url=}}</ref><ref name="pmid10609948">{{cite journal |vauthors=Penn I, First MR |title=Merkel's cell carcinoma in organ recipients: report of 41 cases |journal=Transplantation |volume=68 |issue=11 |pages=1717–21 |date=December 1999 |pmid=10609948 |doi= |url=}}</ref><ref name="pmid11853800">{{cite journal |vauthors=Engels EA, Frisch M, Goedert JJ, Biggar RJ, Miller RW |title=Merkel cell carcinoma and HIV infection |journal=Lancet |volume=359 |issue=9305 |pages=497–8 |date=February 2002 |pmid=11853800 |doi=10.1016/S0140-6736(02)07668-7 |url=}}</ref><ref name="pmid17651025">{{cite journal |vauthors=Manganoni MA, Farisoglio C, Tucci G, Venturini M, Marocolo D, Aquilano MC, El-Hamad I, Ferrari VD, Calzavara Pinton PG |title=Merkel cell carcinoma and HIV infection: a case report and review of the literature |journal=AIDS Patient Care STDS |volume=21 |issue=7 |pages=447–51 |date=July 2007 |pmid=17651025 |doi=10.1089/apc.2006.0152 |url=}}</ref>
** [[Human Immunodeficiency Virus (HIV)|HIV]] positive patients  
** [[Human Immunodeficiency Virus (HIV)|HIV]] positive patients  
Line 23: Line 23:
Less common causes of [[merkel cell carcinoma]] include:
Less common causes of [[merkel cell carcinoma]] include:
* Age
* Age
** The risk increases with the [[age]] and the median age is around 65 years or above  
** The risk increases with the [[age]] and the median age is around 65 years or above.


* Location in the body from decreasing order
* Location in the body from decreasing order

Latest revision as of 02:22, 31 January 2019

Merkel cell cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Merkel Cell Cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Merkel cell cancer causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Merkel cell cancer causes

All Images
X-rays
Echo and Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Merkel cell cancer causes

CDC on Merkel cell cancer causes

Merkel cell cancer causes in the news

Blogs on Merkel cell cancer causes

Directions to Hospitals Treating Merkel cell cancer

Risk calculators and risk factors for Merkel cell cancer causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

Common causes of merkel cell carcinoma include merkel cell polyomavirus, age, skin tone, exposure to sunlight and history of immunosuppression.

Cause

Common Causes

Common causes of merkel cell carcinoma may include:[1][2]

Less Common Causes

Less common causes of merkel cell carcinoma include:

  • Age
    • The risk increases with the age and the median age is around 65 years or above.

Genetic Causes


References

  1. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF, Nghiem P (March 2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J. Am. Acad. Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.
  2. Feng, H.; Shuda, M.; Chang, Y.; Moore, P. S. (2008). "Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma". Science. 319 (5866): 1096–100. doi:10.1126/science.1152586. PMC 2740911. PMID 18202256.
  3. Carter JJ, Paulson KG, Wipf GC, Miranda D, Madeleine MM, Johnson LG, Lemos BD, Lee S, Warcola AH, Iyer JG, Nghiem P, Galloway DA (November 2009). "Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma". J. Natl. Cancer Inst. 101 (21): 1510–22. doi:10.1093/jnci/djp332. PMC 2773184. PMID 19776382.
  4. Miller RW, Rabkin CS (February 1999). "Merkel cell carcinoma and melanoma: etiological similarities and differences". Cancer Epidemiol. Biomarkers Prev. 8 (2): 153–8. PMID 10067813.
  5. Agelli M, Clegg LX (November 2003). "Epidemiology of primary Merkel cell carcinoma in the United States". J. Am. Acad. Dermatol. 49 (5): 832–41. doi:10.1067/S0190. PMID 14576661.
  6. Clarke CA, Robbins HA, Tatalovich Z, Lynch CF, Pawlish KS, Finch JL, Hernandez BY, Fraumeni JF, Madeleine MM, Engels EA (February 2015). "Risk of merkel cell carcinoma after solid organ transplantation". J. Natl. Cancer Inst. 107 (2). doi:10.1093/jnci/dju382. PMC 4311175. PMID 25575645.
  7. Penn I, First MR (December 1999). "Merkel's cell carcinoma in organ recipients: report of 41 cases". Transplantation. 68 (11): 1717–21. PMID 10609948.
  8. Engels EA, Frisch M, Goedert JJ, Biggar RJ, Miller RW (February 2002). "Merkel cell carcinoma and HIV infection". Lancet. 359 (9305): 497–8. doi:10.1016/S0140-6736(02)07668-7. PMID 11853800.
  9. Manganoni MA, Farisoglio C, Tucci G, Venturini M, Marocolo D, Aquilano MC, El-Hamad I, Ferrari VD, Calzavara Pinton PG (July 2007). "Merkel cell carcinoma and HIV infection: a case report and review of the literature". AIDS Patient Care STDS. 21 (7): 447–51. doi:10.1089/apc.2006.0152. PMID 17651025.