Membranous glomerulonephritis pathophysiology

Membranous glomerulonephritis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Membranous glomerulonephritis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
CT
Ultrasound
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Membranous glomerulonephritis pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Membranous glomerulonephritis pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Membranous glomerulonephritis pathophysiology
CDC on Membranous glomerulonephritis pathophysiology
Membranous glomerulonephritis pathophysiology in the news
Blogs on Membranous glomerulonephritis pathophysiology
Directions to Hospitals Treating Membranous glomerulonephritis
Risk calculators and risk factors for Membranous glomerulonephritis pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].

Pathophysiology

Phospholipase A2 receptor

• The M-type PLA2R is the major antigen in human idiopathic MN. It is expressed in glomerular podocytes.
• There was no colocalization of PLA2R in secondary MN biopsies.
• PLA2R antigen detected within immune deposits by immunofluorescence of the biopsy specimen. [26]
• Detection of the immune complex specificity is 100 percent.

Thrombospondin type-1

• THSD7A has been found in patients with idiopathic MN who are negative for anti-PLA2R antibodies.

Neutral endopeptidase

• Anti-neutral endopeptidase antibodies caused MN in the neonates.
• It resolves months after birth.

• The T helper-2 predominates in MN and minimal change disease.

References

• 

  Membranous Glomerulonephritis: Electron micrography. An excellent example to show thickened basement membrane and immune complexes.

• 

  Membranous Glomerulonephritis: Micro trichrome high mag excellent to show thickened capillary basement membranes

• 

  Membranous Glomerulonephritis: Micro PAS high mag excellent example of this lesion

• 

  Membranous Glomerulonephritis: Micro PAS med mag