Maturity onset diabetes of the young: Difference between revisions

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{{SK}} MODY;
{{SK}} MODY;
==Management==
Unfortunately, chronic hyperglycemia of any cause can eventually cause blood vessel damage and the microvascular complications of diabetes. The principal treatment goals for people with MODY — keeping the blood sugars as close to normal as possible ("good [[Diabetes management#Glycemic control|glycemic control]]"), while minimizing other vascular risk factors — are the same for all known forms of diabetes.
Tools available for management are also those available for all forms of diabetes: blood testing, changes in [[diet (nutrition)|diet]], physical [[exercise]], oral hypoglycemic agents, and insulin injections. In many cases these goals can be achieved more easily with MODY than with ordinary types 1 and 2 diabetes. Some people with MODY may require insulin injections to achieve the same [[Diabetes management#Glycemic control|glycemic control]] that another person may attain with careful eating or an oral medication.
When oral hypoglycemic agents are used in MODY, the sulfonylureas remain the oral medication of first resort. Patients with MODY less often suffer from obesity and [[insulin resistance]] than those with ordinary type 2 diabetes (for whom insulin sensitizers like [[metformin]] or the [[thiazolidinedione]]s are often preferred over the sulfonylureas).


==References==
==References==

Revision as of 01:55, 20 September 2012

Maturity onset diabetes of the young
OMIM 606391
DiseasesDB 8330
MeSH D003924

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: MODY;

References

Further reading

  • Fajans SS (1990). "Scope and heterogeneous nature of MODY". Diabetes Care. 13 (1): 49–64. doi:10.2337/diacare.13.1.49. PMID 2404717. (For historical perspective, this review covers the concept just before the nature of the first of the specific molecular defects was discovered. It illustrates the significant change in the disease(s) referred to as MODY before and after 1990.)
  • Dean L and McEntyre J, 2004. The Genetic Landscape of Diabetes. Bethesda:NCBI, 2004. This is an entire online textbook on the complex genetics of the forms of diabetes. The chapter on MODY provides an up-to-date and concise overview of the molecular defects. Little expansion of clinical knowledge of the 6 types since 2001 has occurred.

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