Marfan's syndrome MRI

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Marfan's syndrome Microchapters


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Editors-In-Chief: William James Gibson, C. Michael Gibson, M.S., M.D.

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [1] ; Assistant Editor-In-Chief: Cassandra Abueg, M.P.H. [2]



Aortic diameter can be measured using echocardiography, computed tomography (CT), or magnetic resonance imaging (MRI). While internal diameter can be measured with echocardiography, CT or MRI are required for measurement of the external vessel diameter which is normally 2 to 4 mm larger than the internal artery diameter. When possible, it is recommended that MRI be used to assess diameter in order to minimize patient exposure to radiation. The most important measurement is the diameter at the sinuses of valsalva, a location particularly prone to dissection in patients with the syndrome. After diagnosis, patients must be followed and the aortic size monitored every 6 months as recommended by the 2010 ACC/AHA/AATS guidelines for thoracic aortic disease. If the diameter is stable and less than 45mm, annual imaging is sufficient. However, if the diameter is greater than 45mm or the diameter is growing appreciably more frequent imaging is necessary.

2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guideline Recommendations: Evaluation and Management of Acute Thoracic Aortic Disease (DO NOT EDIT)[1]

Aortic Imaging in Marfan Syndrome (DO NOT EDIT)[1]

Class I
"1. Annual imaging is recommended for patients with Marfan syndrome if stability of the aortic diameter is documented. If the maximal aortic diameter is 4.5 cm or greater, or if the aortic diameter shows significant growth from baseline, more frequent imaging should be considered. (Level of Evidence: C)"


  1. 1.0 1.1 Hiratzka LF, Bakris GL, Beckman JA; et al. (2010). "2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine". Circulation. 121 (13): e266–369. doi:10.1161/CIR.0b013e3181d4739e. PMID 20233780. Unknown parameter |month= ignored (help)

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