Magnesium chloride

Magnesium chloride
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

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Overview

Magnesium chloride is an electrolyte that is FDA approved for the treatment of as an electrolyte replenisher in magnesium deficiencies. Common adverse reactions include flushing, sweating, sharply lowered blood pressure, hypothermia, stupor, and ultimately respiratory depression.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

• As an electrolyte replenisher in magnesium deficiencies.
• For intravenous infusion: 4 grams in 250 mL of 5% Dextrose Injection, at a rate not exceeding 3 mL per minute. Serum magnesium levels should serve as a guide to continued dosage.
• USUAL DOSAGE RANGE: 1 to 40 grams daily.
• Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium chloride in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium chloride in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Magnesium chloride in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium chloride in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium chloride in pediatric patients.

Contraindications

• Magnesium Chloride Injection should not be administered if there is renal impairment, marked myocardial disease or to comatose patients.

Warnings

• Do not use if a precipitate is present.
• This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
• Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Magnesium chloride in the drug label.

Postmarketing Experience

• Flushing, sweating, sharply lowered blood pressure, hypothermia, stupor, and ultimately respiratory depression.

Drug Interactions

There is limited information regarding Magnesium chloride Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): C

• Animal reproduction studies have not been conducted with magnesium chloride. It is also not known whether magnesium chloride can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Magnesium chloride should be given to a pregnant woman only if clearly needed.

Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Magnesium chloride in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Magnesium chloride during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Magnesium chloride with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Magnesium chloride with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Magnesium chloride with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Magnesium chloride with respect to specific gender populations.

Race

There is no FDA guidance on the use of Magnesium chloride with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Magnesium chloride in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Magnesium chloride in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Magnesium chloride in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Magnesium chloride in patients who are immunocompromised.

Administration and Monitoring

Administration

• Intravenous

Monitoring

There is limited information regarding Monitoring of Magnesium chloride in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Magnesium chloride in the drug label.

Overdosage

There is limited information regarding Magnesium chloride overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

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Template:Chembox header2 | Magnesium chloride
Identifiers
CAS Number	7786-30-3 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:6636 Y
ChEMBL	ChEMBL1200547 N
ChemSpider	22987 Y
ECHA InfoCard
PubChem CID	24584
InChI InChI=1S/2ClH.Mg/h2*1H;/q;;+2/p-2 Y Key: TWRXJAOTZQYOKJ-UHFFFAOYSA-L Y InChI=1S/2ClH.Mg/h2*1H;/q;;+2/p-2
SMILES [Mg+2].[Cl-].[Cl-]
Properties
Chemical formula	MgCl2
Molar mass	95.211 g/mol (anhydrous) 203.31 g/mol (hexahydrate)
Hazards
Related compounds
Template:Chembox header2 | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Mechanism of Action

There is limited information regarding Magnesium chloride Mechanism of Action in the drug label.

Structure

• Magnesium Chloride Injection is a sterile solution of Magnesium Chloride Hexahydrate in Water for Injection q.s. Each mL contains: Magnesium Chloride Hexahydrate 200 mg, Sodium Chloride 9 mg, Benzyl Alcohol 1% as a preservative, Water for Injection, q.s. pH adjusted with Hydrochloric Acid and/or Sodium Hydroxide. Total osmolarity equivalent to 2951 mOsmol/L. Contains 1.97 mEq of Mg++ and Cl¯ per mL.
• The structural formula is MgCl2•6H2O

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Magnesium chloride in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Magnesium chloride in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Magnesium chloride in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Magnesium chloride in the drug label.

How Supplied

• Magnesium Chloride Injection 200 mg/mL (20% w/v)
• NDC 0517-5034-01 50 mL Multiple Dose Vial Individually boxed

Storage

• Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F)

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Magnesium chloride in the drug label.

Precautions with Alcohol

• Alcohol-Magnesium chloride interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

• MAGNESIUM CHLORIDE ®

Look-Alike Drug Names

There is limited information regarding Magnesium chloride Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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