MSH2

MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
File:PBB Protein MSH2 image.jpg PDB rendering based on 2o8b.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2o8b​, 2o8c​, 2o8d​, 2o8e​, 2o8f​
Identifiers
Symbols	MSH2 ; HNPCC; COCA1; FCC1; HNPCC1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 210
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MSH2 209421 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

MSH2 is a gene commonly associated with Hereditary nonpolyposis colorectal cancer.

MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.

Further reading

• Jiricny J (1994). "Colon cancer and DNA repair: have mismatches met their match?". Trends Genet. 10 (5): 164–8. PMID 8036718.
• Fishel R, Wilson T (1997). "MutS homologs in mammalian cells". Curr. Opin. Genet. Dev. 7 (1): 105–13. PMID 9024626.
• Lothe RA (1997). "Microsatellite instability in human solid tumors". Molecular medicine today. 3 (2): 61–8. PMID 9060003.
• Peltomäki P, de la Chapelle A (1997). "Mutations predisposing to hereditary nonpolyposis colorectal cancer". Adv. Cancer Res. 71: 93–119. PMID 9111864.
• Papadopoulos N, Lindblom A (1997). "Molecular basis of HNPCC: mutations of MMR genes". Hum. Mutat. 10 (2): 89–99. doi:10.1002/(SICI)1098-1004(1997)10:2<89::AID-HUMU1>3.0.CO;2-H. PMID 9259192.
• Kauh J, Umbreit J (2004). "Colorectal cancer prevention". Current problems in cancer. 28 (5): 240–64. PMID 15375803.
• Warusavitarne J, Schnitzler M (2007). "The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer". International journal of colorectal disease. 22 (7): 739–48. doi:10.1007/s00384-006-0228-0. PMID 17109103.
• Wei Q, Xu X, Cheng L; et al. (1995). "Simultaneous amplification of four DNA repair genes and beta-actin in human lymphocytes by multiplex reverse transcriptase-PCR". Cancer Res. 55 (21): 5025–9. PMID 7585546.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilson TM, Ewel A, Duguid JR; et al. (1995). "Differential cellular expression of the human MSH2 repair enzyme in small and large intestine". Cancer Res. 55 (22): 5146–50. PMID 7585562.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Drummond JT, Li GM, Longley MJ, Modrich P (1995). "Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells". Science. 268 (5219): 1909–12. PMID 7604264.CS1 maint: Multiple names: authors list (link)
• Kolodner RD, Hall NR, Lipford J; et al. (1995). "Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations". Genomics. 24 (3): 516–26. PMID 7713503.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wijnen J, Vasen H, Khan PM; et al. (1995). "Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis". Am. J. Hum. Genet. 56 (5): 1060–6. PMID 7726159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mary JL, Bishop T, Kolodner R; et al. (1995). "Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development". Hum. Mol. Genet. 3 (11): 2067–9. PMID 7874129.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fishel R, Ewel A, Lescoe MK (1994). "Purified human MSH2 protein binds to DNA containing mismatched nucleotides". Cancer Res. 54 (21): 5539–42. PMID 7923193.CS1 maint: Multiple names: authors list (link)
• Fishel R, Ewel A, Lee S; et al. (1994). "Binding of mismatched microsatellite DNA sequences by the human MSH2 protein". Science. 266 (5189): 1403–5. PMID 7973733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu B, Parsons RE, Hamilton SR; et al. (1994). "hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds". Cancer Res. 54 (17): 4590–4. PMID 8062247.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Fishel R, Lescoe MK, Rao MR; et al. (1994). "The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer". Cell. 77 (1): 167. PMID 8156592.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fishel R, Lescoe MK, Rao MR; et al. (1994). "The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer". Cell. 75 (5): 1027–38. PMID 8252616.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

See also

• Mismatch_repair#MutS

External links

• MutS+Homolog+2+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)