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{{Infobox_gene}}
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'''Microtubule-associated protein 1A''' is a [[protein]] that in humans is encoded by the ''MAP1A'' [[gene]].<ref name="pmid7806212">{{cite journal | vauthors = Lien LL, Feener CA, Fischbach N, Kunkel LM | title = Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15 | journal = Genomics | volume = 22 | issue = 2 | pages = 273–80 | date = July 1994 | pmid = 7806212 | doi = 10.1006/geno.1994.1384 }}</ref><ref name="pmid7629894">{{cite journal | vauthors = Fukuyama R, Rapoport SI | title = Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15 | journal = J. Neurosci. Res. | volume = 40 | issue = 6 | pages = 820–5  | date = Sep 1995 | pmid = 7629894 | pmc =  | doi = 10.1002/jnr.490400613 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP1A microtubule-associated protein 1A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4130| accessdate = }}</ref>
| update_page = yes
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| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Microtubule-associated protein 1A
| HGNCid = 6835
| Symbol = MAP1A
| AltSymbols =; MAP1L; MTAP1A
| OMIM = 600178
| ECnumber = 
| Homologene = 1778
| MGIid = 
| GeneAtlas_image1 = PBB_GE_MAP1A_203151_at_tn.png
| GeneAtlas_image2 = PBB_GE_MAP1A_215384_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4130
    | Hs_Ensembl = ENSG00000166963
    | Hs_RefseqProtein = NP_002364
    | Hs_RefseqmRNA = NM_002373
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 41590448
    | Hs_GenLoc_end = 41611110
    | Hs_Uniprot = P78559
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Microtubule-associated protein 1A''', also known as '''MAP1A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP1A microtubule-associated protein 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4130| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.<ref name="entrez">{{cite web | title = Entrez Gene: MAP1A microtubule-associated protein 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4130| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAP1A has been shown to [[Protein-protein interaction|interact]] with [[DISC1]].<ref name=pmid12812986>{{cite journal | vauthors = Morris JA, Kandpal G, Ma L, Austin CP | title = DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation | journal = Hum. Mol. Genet. | volume = 12 | issue = 13 | pages = 1591–608  | date = Jul 2003 | pmid = 12812986 | doi = 10.1093/hmg/ddg162 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Snásel J, Pichová I | title = The cleavage of host cell proteins by HIV-1 protease | journal = Folia Biol. (Praha) | volume = 42 | issue = 5 | pages = 227–30 | year = 1996 | pmid = 8997639 | doi = 10.1007/BF02818986 }}
| citations =
* {{cite journal | vauthors = Wallin M, Deinum J, Goobar L, Danielson UH | title = Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases | journal = J. Gen. Virol. | volume = 71 ( Pt 9) | issue = 9 | pages = 1985–91 | year = 1990 | pmid = 2212989 | doi = 10.1099/0022-1317-71-9-1985 }}
*{{cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227-30 |year= 1997 |pmid= 8997639 |doi= }}
* {{cite journal | vauthors = Schoenfeld TA, McKerracher L, Obar R, Vallee RB | title = MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS | journal = J. Neurosci. | volume = 9 | issue = 5 | pages = 1712–30 | year = 1989 | pmid = 2470876 | doi =  }}
*{{cite journal | author=Wallin M, Deinum J, Goobar L, Danielson UH |title=Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases. |journal=J. Gen. Virol. |volume=71 ( Pt 9) |issue= |pages= 1985-91 |year= 1990 |pmid= 2212989 |doi= }}
* {{cite journal | vauthors = Bloom GS, Luca FC, Vallee RB | title = Widespread cellular distribution of MAP-1A (microtubule-associated protein 1A) in the mitotic spindle and on interphase microtubules | journal = J. Cell Biol. | volume = 98 | issue = 1 | pages = 331–40 | year = 1984 | pmid = 6142895 | pmc = 2113021 | doi = 10.1083/jcb.98.1.331 }}
*{{cite journal | author=Schoenfeld TA, McKerracher L, Obar R, Vallee RB |title=MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS. |journal=J. Neurosci. |volume=9 |issue= 5 |pages= 1712-30 |year= 1989 |pmid= 2470876 |doi=  }}
* {{cite journal | vauthors = Pedrotti B, Colombo R, Islam K | title = Microtubule associated protein MAP1A is an actin-binding and crosslinking protein | journal = Cell Motil. Cytoskeleton | volume = 29 | issue = 2 | pages = 110–6 | year = 1994 | pmid = 7820861 | doi = 10.1002/cm.970290203 }}
*{{cite journal | author=Bloom GS, Luca FC, Vallee RB |title=Widespread cellular distribution of MAP-1A (microtubule-associated protein 1A) in the mitotic spindle and on interphase microtubules. |journal=J. Cell Biol. |volume=98 |issue= 1 |pages= 331-40 |year= 1984 |pmid= 6142895 |doi= }}
* {{cite journal | vauthors = Fujii T, Watanabe M, Ogoma Y, Kondo Y, Arai T | title = Microtubule-associated proteins, MAP 1A and MAP 1B, interact with F-actin in vitro | journal = J. Biochem. | volume = 114 | issue = 6 | pages = 827–9 | year = 1993 | pmid = 7908020 | doi =  }}
*{{cite journal  | author=Fukuyama R, Rapoport SI |title=Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. |journal=J. Neurosci. Res. |volume=40 |issue= 6 |pages= 820-5 |year= 1995 |pmid= 7629894 |doi= 10.1002/jnr.490400613 }}
* {{cite journal | vauthors = Mann SS, Hammarback JA | title = Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B | journal = J. Biol. Chem. | volume = 269 | issue = 15 | pages = 11492–7 | year = 1994 | pmid = 7908909 | doi =  }}
*{{cite journal  | author=Lien LL, Feener CA, Fischbach N, Kunkel LM |title=Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. |journal=Genomics |volume=22 |issue= 2 |pages= 273-80 |year= 1995 |pmid= 7806212 |doi= 10.1006/geno.1994.1384 }}
* {{cite journal | vauthors = Fink JK, Jones SM, Esposito C, Wilkowski J | title = Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression | journal = Genomics | volume = 35 | issue = 3 | pages = 577–85 | year = 1996 | pmid = 8812494 | doi = 10.1006/geno.1996.0400 }}
*{{cite journal | author=Pedrotti B, Colombo R, Islam K |title=Microtubule associated protein MAP1A is an actin-binding and crosslinking protein. |journal=Cell Motil. Cytoskeleton |volume=29 |issue= 2 |pages= 110-6 |year= 1995 |pmid= 7820861 |doi= 10.1002/cm.970290203 }}
* {{cite journal | vauthors = Vaillant AR, Müller R, Langkopf A, Brown DL | title = Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics | journal = J. Biol. Chem. | volume = 273 | issue = 22 | pages = 13973–81 | year = 1998 | pmid = 9593747 | doi = 10.1074/jbc.273.22.13973 }}
*{{cite journal | author=Fujii T, Watanabe M, Ogoma Y, ''et al.'' |title=Microtubule-associated proteins, MAP 1A and MAP 1B, interact with F-actin in vitro. |journal=J. Biochem. |volume=114 |issue= 6 |pages= 827-9 |year= 1994 |pmid= 7908020 |doi=  }}
* {{cite journal | vauthors = Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS | title = Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A | journal = J. Neurosci. | volume = 18 | issue = 21 | pages = 8805–13 | year = 1998 | pmid = 9786987 | doi =  }}
*{{cite journal | author=Mann SS, Hammarback JA |title=Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11492-7 |year= 1994 |pmid= 7908909 |doi=  }}
* {{cite journal | vauthors = Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS | title = A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome | journal = J. Cell Biol. | volume = 149 | issue = 1 | pages = 67–80 | year = 2000 | pmid = 10747088 | pmc = 2175106 | doi = 10.1083/jcb.149.1.67 }}
*{{cite journal | author=Fink JK, Jones SM, Esposito C, Wilkowski J |title=Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. |journal=Genomics |volume=35 |issue= 3 |pages= 577-85 |year= 1996 |pmid= 8812494 |doi= 10.1006/geno.1996.0400 }}
* {{cite journal | vauthors = Mei X, Sweatt AJ, Hammarback JA | title = Regulation of microtubule-associated protein 1B (MAP1B) subunit composition | journal = J. Neurosci. Res. | volume = 62 | issue = 1 | pages = 56–64 | year = 2000 | pmid = 11002287 | doi = 10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-# }}
*{{cite journal | author=Vaillant AR, Müller R, Langkopf A, Brown DL |title=Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13973-81 |year= 1998 |pmid= 9593747 |doi= }}
* {{cite journal | vauthors = Ulfig N, Feldhaus C, Setzer M, Bohl J | title = Expression of MAP1a and MAP1b in the ganglionic eminence and the internal capsule of the human fetal brain | journal = Neurosci. Res. | volume = 38 | issue = 4 | pages = 397–405 | year = 2000 | pmid = 11164566 | doi = 10.1016/S0168-0102(00)00189-9 }}
*{{cite journal | author=Brenman JE, Topinka JR, Cooper EC, ''et al.'' |title=Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. |journal=J. Neurosci. |volume=18 |issue= 21 |pages= 8805-13 |year= 1998 |pmid= 9786987 |doi=  }}
* {{cite journal | vauthors = Bonnet C, Boucher D, Lazereg S, Pedrotti B, Islam K, Denoulet P, Larcher JC | title = Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 12839–48 | year = 2001 | pmid = 11278895 | doi = 10.1074/jbc.M011380200 }}
*{{cite journal | author=Hirst J, Lui WW, Bright NA, ''et al.'' |title=A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome. |journal=J. Cell Biol. |volume=149 |issue= 1 |pages= 67-80 |year= 2000 |pmid= 10747088 |doi= }}
* {{cite journal | vauthors = Orzech E, Livshits L, Leyt J, Okhrimenko H, Reich V, Cohen S, Weiss A, Melamed-Book N, Lebendiker M, Altschuler Y, Aroeti B | title = Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins | journal = J. Biol. Chem. | volume = 276 | issue = 33 | pages = 31340–8 | year = 2001 | pmid = 11418592 | doi = 10.1074/jbc.M101054200 }}
*{{cite journal | author=Mei X, Sweatt AJ, Hammarback JA |title=Regulation of microtubule-associated protein 1B (MAP1B) subunit composition. |journal=J. Neurosci. Res. |volume=62 |issue= 1 |pages= 56-64 |year= 2000 |pmid= 11002287 |doi= }}
* {{cite journal | vauthors = Noiges R, Eichinger R, Kutschera W, Fischer I, Nemeth Z, Wiche G, Propst F | title = Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties | journal = J. Neurosci. | volume = 22 | issue = 6 | pages = 2106–14 | year = 2002 | pmid = 11896150 | doi =  }}
*{{cite journal | author=Ulfig N, Feldhaus C, Setzer M, Bohl J |title=Expression of MAP1a and MAP1b in the ganglionic eminence and the internal capsule of the human fetal brain. |journal=Neurosci. Res. |volume=38 |issue= 4 |pages= 397-405 |year= 2001 |pmid= 11164566 |doi= }}
* {{cite journal | vauthors = Ikeda A, Zheng QY, Zuberi AR, Johnson KR, Naggert JK, Nishina PM | title = Microtubule-associated protein 1A is a modifier of tubby hearing (moth1) | journal = Nat. Genet. | volume = 30 | issue = 4 | pages = 401–5 | year = 2002 | pmid = 11925566 | pmc = 2862212 | doi = 10.1038/ng838 }}
*{{cite journal | author=Bonnet C, Boucher D, Lazereg S, ''et al.'' |title=Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12839-48 |year= 2001 |pmid= 11278895 |doi= 10.1074/jbc.M011380200 }}
*{{cite journal | author=Orzech E, Livshits L, Leyt J, ''et al.'' |title=Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 31340-8 |year= 2001 |pmid= 11418592 |doi= 10.1074/jbc.M101054200 }}
*{{cite journal | author=Noiges R, Eichinger R, Kutschera W, ''et al.'' |title=Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. |journal=J. Neurosci. |volume=22 |issue= 6 |pages= 2106-14 |year= 2002 |pmid= 11896150 |doi=  }}
*{{cite journal | author=Ikeda A, Zheng QY, Zuberi AR, ''et al.'' |title=Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). |journal=Nat. Genet. |volume=30 |issue= 4 |pages= 401-5 |year= 2002 |pmid= 11925566 |doi= 10.1038/ng838 }}
}}
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{{gene-15-stub}}

Latest revision as of 12:42, 9 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Microtubule-associated protein 1A is a protein that in humans is encoded by the MAP1A gene.[1][2][3]

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.[3]

Interactions

MAP1A has been shown to interact with DISC1.[4]

References

  1. ↑ Lien LL, Feener CA, Fischbach N, Kunkel LM (July 1994). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics. 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.
  2. ↑ Fukuyama R, Rapoport SI (Sep 1995). "Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15". J. Neurosci. Res. 40 (6): 820–5. doi:10.1002/jnr.490400613. PMID 7629894.
  3. ↑ 3.0 3.1 "Entrez Gene: MAP1A microtubule-associated protein 1A".
  4. ↑ Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.

Further reading


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