Liposarcoma classification: Difference between revisions

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Latest revision as of 20:22, 20 May 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]

Overview

Liposarcoma may be classified into well-differentiated, de-differentiated, myxoid, round cell, or pleomorphic liposarcoma.

Classification

Liposarcoma is a type of soft tissue sarcoma, which accounts for approximately 20% of the mesenchymal malignancies. Liposarcomas may be classified into different subtypes, according to their histologic, cytogenetic, biologic, and molecular features. The World Health Organization proposed the following classification of liposarcomas:^[1]^[2]^[3]


WHO Classification of Liposarcoma^[3]
Well-diferentiated liposarcoma: Adipocytic or lipoma-like Inflammatory Sclerosing De-differentiated liposarcoma Myxoid-round cell liposarcoma (MRCLS) Pleomorphic liposarcoma Liposarcoma, not otherwise specified

References

↑ Weiss, Sharon (1994). Histological typing of soft tissue tumours. Berlin New York: Springer-Verlag. ISBN 3540567941.
↑ Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.
↑ ^3.0 ^3.1 "WHO Classification of Soft Tissue Tumors" (PDF). WHO. WHO. Retrieved Sep 25 2014. Check date values in: |accessdate= (help)}}

Template:WikiDoc Sources

[1] Weiss, Sharon (1994). Histological typing of soft tissue tumours. Berlin New York: Springer-Verlag. ISBN 3540567941.

[pmid10982304-2] Dei Tos AP (2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol. 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.

[WHO-3] 3.0 ^3.1 "WHO Classification of Soft Tissue Tumors" (PDF). WHO. WHO. Retrieved Sep 25 2014. Check date values in: |accessdate= (help)}}

[1]

[2]

[3]

@@ Line 4: / Line 4: @@
 ==Overview==
+Liposarcoma may be [[Classification|classified]] into well-differentiated, de-differentiated, myxoid, round [[Cell (biology)|cell]], or [[Pleomorphism|pleomorphic]] liposarcoma.
 ==Classification==
-Liposarcoma is one type of [[soft tissue sarcoma]]s, which accounts for about 20% of the [[mesenchymal]] [[malignancies]].  Liposarcomas may be classified into different types, according to their histologic, cytogenetic, biologic and molecular features.  The [[WHO]] has proposed the following classification of liposarcomas:<ref>{{cite book | last = Weiss | first = Sharon | title = Histological typing of soft tissue tumours | publisher = Springer-Verlag | location = Berlin New York | year = 1994 | isbn = 3540567941 }}</ref><ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref>
+Liposarcoma is a type of [[soft tissue sarcoma]], which accounts for approximately 20% of the [[mesenchymal]] [[malignancies]].  Liposarcomas may be [[Classification|classified]] into different subtypes, according to their [[Histology|histologic]], [[Cytogenetics|cytogenetic]], [[Biology|biologic]], and [[Molecule|molecular]] features.  The [[World Health Organization]] proposed the following [[classification]] of liposarcomas:<ref>{{cite book | last = Weiss | first = Sharon | title = Histological typing of soft tissue tumours | publisher = Springer-Verlag | location = Berlin New York | year = 1994 | isbn = 3540567941 }}</ref><ref name="pmid10982304">{{cite journal| author=Dei Tos AP| title=Liposarcoma: new entities and evolving concepts. | journal=Ann Diagn Pathol | year= 2000 | volume= 4 | issue= 4 | pages= 252-66 | pmid=10982304 | doi=10.1053/adpa.2000.8133 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10982304  }} </ref><ref name="WHO">{{cite web |url=http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb5/bb5-classifsofttissue.pdf |title=WHO Classification of Soft Tissue Tumors |last1= |first1= |last2= |first2= |date= |website=WHO |publisher=WHO |accessdate=Sep 25 2014}}<nowiki>}}</nowiki></ref>
-*Well-diferentiated liposarcoma:
-:*Adipocytic or lipoma-like
-:*Inflammatory
-:*Sclerosing
-*Dedifferentiated liposarcoma
-*Myxoid liposarcoma
-*Round cell liposarcoma
-*Pleiomorphic liposarcoma
+{| style="border: 0px; font-size: 100%; margin: 3px;" align="center"
-{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
 |+
-! style="background: #4479BA; width: 500px;" | {{fontcolor|#FFF|Significance}}
+! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|WHO Classification of Liposarcoma<ref name=WHO>{{cite web |url=http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb5/bb5-classifsofttissue.pdf |title=WHO Classification of Soft Tissue Tumors |last1= |first1= |last2= |first2= |date= |website=WHO |publisher=WHO |accessdate=Sep 25 2014}}</ref>}}
 |-
 | style="padding: 5px 5px; background: #F5F5F5;" |
+*Well-diferentiated liposarcoma:
+:*[[Adipocyte|Adipocytic]] or [[lipoma]]-like
+:*[[Inflammation|Inflammatory]]
+:*[[Sclerosis|Sclerosing]]
+*De-differentiated liposarcoma
+*Myxoid-round cell liposarcoma (MRCLS)
+*[[Pleomorphism|Pleomorphic]] liposarcoma
+*Liposarcoma, not otherwise specified
 |-
 |}
-<!--
-it is useful to think of liposarcomas as three large groups from a conceptual point of view. ALN/WDL, also termed atypical lipomatous neoplasm (ALN) when it occurs in superficial soft tissue or in the muscles of the extremity because of its low-grade behavior, and dedifferentiated liposarcoma (DL) comprise one subgroup. Widely disparate in terms of biologic behavior, they are closely related from a pathogenetic point of view because a subset of ALN/WDL histologically progresses to dedifferentiated sarcomas. With dedifferentiation, the tumor acquires metastatic potential, a phenomenon accompanied by additional cytogenetic abnormalities. The second group is myxoid liposarcoma that ranges in appearance from pure myxoid tumors at one extreme to poorly differentiated round cell (poorly differentiated myxoid) tumors at the other. Pleomorphic liposarcomas are rare, poorly characterized tumors, many of which resemble undifferentiated pleomorphic sarcoma, except for the presence of pleomorphic lipoblasts. Finally, a small number of liposarcomas exhibit unusual features or combine patterns not accounted for in the previous classification (liposarcomas of mixed type). These are best individualized and diagnosed as liposarcomas of mixed or unclassifiable type, recognizing that the number of such lesions is dwindling because of the ability of molecular testing to assign them to a category.
--->
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Liposarcoma classification: Difference between revisions

Latest revision as of 20:22, 20 May 2019

Overview

Classification

References

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